A potassium-transporting ATPase subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51164]
Gastric H(+)/K(+) ATPase subunit beta;
Proton pump beta chain
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cimetidine | Homo sapiens (human) | IC50 | 50.4100 | 2 | 2 |
| omeprazole | Homo sapiens (human) | IC50 | 1.4500 | 5 | 6 |
| ranitidine | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| timoprazole | Homo sapiens (human) | IC50 | 130.0000 | 1 | 2 |
| 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole | Homo sapiens (human) | IC50 | 0.7000 | 1 | 2 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| P-type potassium:proton transporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). [RHEA:22044] |
| heterocyclic compound binding | molecular function | Binding to heterocyclic compound. [GOC:TermGenie] |
| ATPase activator activity | molecular function | Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| potassium:proton exchanging ATPase complex | cellular component | A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present. [PMID:11756431] |
| sodium:potassium-exchanging ATPase complex | cellular component | Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| cell adhesion | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
| response to organonitrogen compound | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. [PMID:9869419] |
| response to lipopolysaccharide | biological process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464] |
| pH reduction | biological process | Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. [GOC:go_curators] |
| potassium ion transmembrane transport | biological process | A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah] |
| proton transmembrane transport | biological process | The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie] |
| potassium ion import across plasma membrane | biological process | The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127] |
| intracellular potassium ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah] |
| sodium ion export across plasma membrane | biological process | The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689] |
| intracellular sodium ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah] |