Putative inactive group IIC secretory phospholipase A2

A group IIC secretory phospholipase A2 that is encoded in the genome of human. A substitution at a conserved active site residue likely renders it inactive. [PRO:DAN, UniProtKB:Q5R387]

Synonyms

Phosphatidylcholine 2-acylhydrolase-like protein GIIC

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
varespladib	Homo sapiens (human)	IC50	0.1225	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3-octylthio-1,1,1-trifluoro-2-propanone	Homo sapiens (human)	XI50	0.0001	1	1
varespladib	Homo sapiens (human)	XI50	0.0010	7	7

Enables

This protein enables 4 target(s):

Target	Category	Definition
calcium-dependent phospholipase A2 activity	molecular function	Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [EC:3.1.1.4]
signaling receptor binding	molecular function	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
phospholipid binding	molecular function	Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
lipid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]
phosphatidylcholine metabolic process	biological process	The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. [ISBN:0198506732]
arachidonic acid secretion	biological process	The controlled release of arachidonic acid from a cell or a tissue. [GOC:ai]
fatty acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:mah, ISBN:0198506732]
positive regulation of fibroblast proliferation	biological process	Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]
phospholipid metabolic process	biological process	The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]