A sterol O-acyltransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35610]
EC 2.3.1.26;
Acyl-coenzyme A:cholesterol acyltransferase 1;
ACAT-1;
Cholesterol acyltransferase 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| diethyl pyrocarbonate | Homo sapiens (human) | IC50 | 44.0000 | 1 | 0 |
| procainamide | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| edrophonium chloride | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| territrem b | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| pd 128042 | Homo sapiens (human) | IC50 | 1.7444 | 6 | 7 |
| cl 277082 | Homo sapiens (human) | IC50 | 0.6800 | 3 | 3 |
| 1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone | Homo sapiens (human) | IC50 | 22.0000 | 1 | 2 |
| atractylenolide iii | Homo sapiens (human) | IC50 | 115.0000 | 2 | 2 |
| avasimibe | Homo sapiens (human) | IC50 | 5.9208 | 5 | 5 |
| 22s-hydroxycholesterol | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| f 1394 | Homo sapiens (human) | IC50 | 0.0320 | 1 | 1 |
| oleic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 2 | 2 |
| beta-hydroxyisovalerylshikonin | Homo sapiens (human) | IC50 | 186.9000 | 1 | 1 |
| shikonin | Homo sapiens (human) | IC50 | 70.4000 | 1 | 1 |
| carbenoxolone | Homo sapiens (human) | IC50 | 0.1080 | 1 | 1 |
| pactimibe | Homo sapiens (human) | IC50 | 2.3333 | 3 | 3 |
| linoleic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 2 | 2 |
| oleylamide | Homo sapiens (human) | IC50 | 74.0000 | 2 | 2 |
| macluraxanthone b | Homo sapiens (human) | IC50 | 96.0000 | 1 | 1 |
| oleoylanilide | Homo sapiens (human) | IC50 | 0.1475 | 4 | 4 |
| Pipercide | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| linoleamide | Homo sapiens (human) | IC50 | 49.0000 | 2 | 2 |
| manzamine a | Homo sapiens (human) | IC50 | 6.3000 | 2 | 2 |
| eflucimibe | Homo sapiens (human) | IC50 | 0.0390 | 1 | 0 |
| arisugacin | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| manassantin b | Homo sapiens (human) | IC50 | 82.0000 | 1 | 0 |
| cudraxanthone l | Homo sapiens (human) | IC50 | 68.0000 | 1 | 1 |
| cudraflavanone a | Homo sapiens (human) | IC50 | 82.4000 | 1 | 1 |
| azd7687 | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| manassantin a | Homo sapiens (human) | IC50 | 23.5000 | 2 | 2 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| fatty-acyl-CoA binding | molecular function | Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. [GOC:jl, GOC:krc, ISBN:0198506732] |
| sterol O-acyltransferase activity | molecular function | Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. [EC:2.3.1.26, GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| cholesterol binding | molecular function | Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732] |
| cholesterol O-acyltransferase activity | molecular function | Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA. [EC:2.3.1.26, RHEA:17729] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| cholesterol metabolic process | biological process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732] |
| macrophage derived foam cell differentiation | biological process | The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:dph, GOC:tb] |
| cholesterol storage | biological process | The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb] |
| cholesterol efflux | biological process | The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:sart] |
| very-low-density lipoprotein particle assembly | biological process | The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle. [GOC:BHF, GOC:mah] |
| low-density lipoprotein particle clearance | biological process | The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:mah] |
| cholesterol homeostasis | biological process | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators] |
| positive regulation of amyloid precursor protein biosynthetic process | biological process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. [GOC:go_curators] |