A prothrombin that is encoded in the genome of cow. [OMA:P00735, PRO:DNx]
EC 3.4.21.5;
Coagulation factor II
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| benzamidine | Bos taurus (cattle) | Ki | 890.0000 | 1 | 1 |
| bis(5-amidino-2-benzimidazolyl)methane | Bos taurus (cattle) | Ki | 4.1500 | 2 | 2 |
| dapi | Bos taurus (cattle) | Ki | 8.3700 | 1 | 1 |
| nevirapine | Bos taurus (cattle) | IC50 | 1.1500 | 1 | 1 |
| 1,2-di(5-amidino-2-benzofuranyl)ethane | Bos taurus (cattle) | Ki | 4.1700 | 1 | 1 |
| efavirenz | Bos taurus (cattle) | IC50 | 0.0220 | 1 | 1 |
| 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose | Bos taurus (cattle) | IC50 | 0.0800 | 2 | 2 |
| 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose | Bos taurus (cattle) | Ki | 3.9000 | 1 | 1 |
| leupeptin | Bos taurus (cattle) | IC50 | 12.0000 | 1 | 1 |
| mci 9038 | Bos taurus (cattle) | Ki | 0.0439 | 3 | 4 |
| dx 9065 | Bos taurus (cattle) | Ki | 2,000.0000 | 1 | 1 |
| efegatran | Bos taurus (cattle) | IC50 | 0.0089 | 1 | 1 |
| 5-amidinoindole | Bos taurus (cattle) | Ki | 7.6800 | 1 | 1 |
| n(alpha)-(4-toluenesulfonyl)-4-amidinophenylalanylpiperidine | Bos taurus (cattle) | Ki | 1.3000 | 1 | 1 |
| 1,2-bis(5-amidino-2-benzimidazolyl)ethane | Bos taurus (cattle) | Ki | 11.6000 | 1 | 1 |
| 2-(4-amidinophenyl)-1-benzofuran-5-carboxamidine | Bos taurus (cattle) | Ki | 11.3000 | 1 | 1 |
| 4-guanidinobenzoate | Bos taurus (cattle) | IC50 | 342.5000 | 1 | 4 |
| Pedunculagin | Bos taurus (cattle) | IC50 | 0.1650 | 2 | 2 |
| Pedunculagin | Bos taurus (cattle) | Ki | 0.0420 | 1 | 1 |
| quercetin | Bos taurus (cattle) | IC50 | 28.7500 | 1 | 4 |
| rutin | Bos taurus (cattle) | IC50 | 42.2000 | 1 | 5 |
| n-alpha-(2,4,6-triisopropyl-phenylsulfonyl)-3-amidino-(l)-phenyl-alanine-4-ethoxycarbonyl-piperazide hydrochloride | Bos taurus (cattle) | Ki | 0.6620 | 1 | 5 |
| lb 30057 | Bos taurus (cattle) | Ki | 0.0011 | 1 | 1 |
| no. 407 | Bos taurus (cattle) | IC50 | 0.3000 | 1 | 1 |