An aldo-keto reductase family 1 member B1 that is encoded in the genome of rat. [PRO:DNx]
EC 1.1.1.21;
EC 1.1.1.300;
EC 1.1.1.372;
EC 1.1.1.54;
Aldehyde reductase;
Aldose reductase;
AR
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 8 (13.79) | 18.7374 |
| 1990's | 7 (12.07) | 18.2507 |
| 2000's | 14 (24.14) | 29.6817 |
| 2010's | 26 (44.83) | 24.3611 |
| 2020's | 3 (5.17) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| quinacrine | Rattus norvegicus (Norway rat) | IC50 | 2.8960 | 1 | 0 |
| quinacrine | Rattus norvegicus (Norway rat) | Ki | 2.8720 | 1 | 0 |
| hippuric acid | Rattus norvegicus (Norway rat) | IC50 | 330.0000 | 2 | 2 |
| zopolrestat | Rattus norvegicus (Norway rat) | IC50 | 0.0152 | 4 | 4 |
| 3-methylcholanthrene | Rattus norvegicus (Norway rat) | IC50 | 29.6500 | 1 | 0 |
| 3-methylcholanthrene | Rattus norvegicus (Norway rat) | Ki | 29.4050 | 1 | 0 |
| 4-nonylphenol | Rattus norvegicus (Norway rat) | IC50 | 1.2540 | 1 | 0 |
| 4-nonylphenol | Rattus norvegicus (Norway rat) | Ki | 1.2440 | 1 | 0 |
| tacrine | Rattus norvegicus (Norway rat) | IC50 | 0.5170 | 1 | 0 |
| tacrine | Rattus norvegicus (Norway rat) | Ki | 0.5130 | 1 | 0 |
| alrestatin | Rattus norvegicus (Norway rat) | IC50 | 1.5000 | 2 | 2 |
| pimagedine | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| amiodarone | Rattus norvegicus (Norway rat) | IC50 | 2.2710 | 1 | 0 |
| amiodarone | Rattus norvegicus (Norway rat) | Ki | 2.2520 | 1 | 0 |
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 0 |
| amitriptyline | Rattus norvegicus (Norway rat) | Ki | 0.0220 | 1 | 0 |
| amoxapine | Rattus norvegicus (Norway rat) | IC50 | 0.0130 | 1 | 0 |
| amoxapine | Rattus norvegicus (Norway rat) | Ki | 0.0130 | 1 | 0 |
| astemizole | Rattus norvegicus (Norway rat) | IC50 | 1.3750 | 1 | 0 |
| astemizole | Rattus norvegicus (Norway rat) | Ki | 1.3640 | 1 | 0 |
| bithionol | Rattus norvegicus (Norway rat) | IC50 | 1.2350 | 1 | 0 |
| bithionol | Rattus norvegicus (Norway rat) | Ki | 1.2250 | 1 | 0 |
| butenafine | Rattus norvegicus (Norway rat) | IC50 | 3.9099 | 1 | 0 |
| butenafine | Rattus norvegicus (Norway rat) | Ki | 3.8775 | 1 | 0 |
| candesartan | Rattus norvegicus (Norway rat) | IC50 | 3.0652 | 1 | 0 |
| candesartan | Rattus norvegicus (Norway rat) | Ki | 3.0398 | 1 | 0 |
| carvedilol | Rattus norvegicus (Norway rat) | IC50 | 0.5380 | 1 | 0 |
| carvedilol | Rattus norvegicus (Norway rat) | Ki | 0.5330 | 1 | 0 |
| celecoxib | Rattus norvegicus (Norway rat) | IC50 | 7.3080 | 1 | 0 |
| celecoxib | Rattus norvegicus (Norway rat) | Ki | 7.2470 | 1 | 0 |
| chlorpromazine | Rattus norvegicus (Norway rat) | IC50 | 0.0190 | 1 | 0 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 0.0190 | 1 | 0 |
| ciglitazone | Rattus norvegicus (Norway rat) | IC50 | 2.2200 | 1 | 0 |
| ciglitazone | Rattus norvegicus (Norway rat) | Ki | 2.2010 | 1 | 0 |
| citalopram | Rattus norvegicus (Norway rat) | IC50 | 2.1960 | 1 | 0 |
| citalopram | Rattus norvegicus (Norway rat) | Ki | 2.1780 | 1 | 0 |
| clomipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0710 | 1 | 0 |
| clomipramine | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 1 | 0 |
| clotrimazole | Rattus norvegicus (Norway rat) | IC50 | 7.9360 | 1 | 0 |
| clotrimazole | Rattus norvegicus (Norway rat) | Ki | 7.8700 | 1 | 0 |
| cyproheptadine | Rattus norvegicus (Norway rat) | IC50 | 0.5640 | 1 | 0 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.5590 | 1 | 0 |
| diphenhydramine | Rattus norvegicus (Norway rat) | IC50 | 3.5420 | 1 | 0 |
| diphenhydramine | Rattus norvegicus (Norway rat) | Ki | 3.5130 | 1 | 0 |
| disulfiram | Rattus norvegicus (Norway rat) | IC50 | 70.3700 | 1 | 0 |
| disulfiram | Rattus norvegicus (Norway rat) | Ki | 69.8120 | 1 | 0 |
| valproic acid | Rattus norvegicus (Norway rat) | IC50 | 56.1000 | 5 | 5 |
| domperidone | Rattus norvegicus (Norway rat) | IC50 | 2.6140 | 1 | 0 |
| domperidone | Rattus norvegicus (Norway rat) | Ki | 2.5930 | 1 | 0 |
| doxepin | Rattus norvegicus (Norway rat) | IC50 | 0.0290 | 1 | 0 |
| doxepin | Rattus norvegicus (Norway rat) | Ki | 0.0290 | 1 | 0 |
| ebastine | Rattus norvegicus (Norway rat) | IC50 | 0.4603 | 1 | 0 |
| ebastine | Rattus norvegicus (Norway rat) | Ki | 0.4564 | 1 | 0 |
| econazole | Rattus norvegicus (Norway rat) | IC50 | 2.4350 | 1 | 0 |
| econazole | Rattus norvegicus (Norway rat) | Ki | 2.4150 | 1 | 0 |
| fenofibrate | Rattus norvegicus (Norway rat) | IC50 | 21.4080 | 1 | 0 |
| fenofibrate | Rattus norvegicus (Norway rat) | Ki | 21.2310 | 1 | 0 |
| fluphenazine | Rattus norvegicus (Norway rat) | IC50 | 1.9620 | 1 | 0 |
| fluphenazine | Rattus norvegicus (Norway rat) | Ki | 1.9460 | 1 | 0 |
| fluoxetine | Rattus norvegicus (Norway rat) | IC50 | 1.3030 | 1 | 0 |
| fluoxetine | Rattus norvegicus (Norway rat) | Ki | 1.2920 | 1 | 0 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 1.8360 | 1 | 0 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 1.8200 | 1 | 0 |
| haloprogin | Rattus norvegicus (Norway rat) | IC50 | 2.7700 | 1 | 0 |
| haloprogin | Rattus norvegicus (Norway rat) | Ki | 2.7470 | 1 | 0 |
| ipriflavone | Rattus norvegicus (Norway rat) | IC50 | 2.5125 | 1 | 0 |
| ipriflavone | Rattus norvegicus (Norway rat) | Ki | 2.4917 | 1 | 0 |
| ketoconazole | Rattus norvegicus (Norway rat) | IC50 | 24.2030 | 1 | 0 |
| ketoconazole | Rattus norvegicus (Norway rat) | Ki | 24.0030 | 1 | 0 |
| labetalol | Rattus norvegicus (Norway rat) | IC50 | 3.3540 | 1 | 0 |
| labetalol | Rattus norvegicus (Norway rat) | Ki | 3.3260 | 1 | 0 |
| leflunomide | Rattus norvegicus (Norway rat) | IC50 | 4.6300 | 1 | 0 |
| leflunomide | Rattus norvegicus (Norway rat) | Ki | 4.5910 | 1 | 0 |
| maprotiline | Rattus norvegicus (Norway rat) | IC50 | 0.0300 | 1 | 0 |
| maprotiline | Rattus norvegicus (Norway rat) | Ki | 0.0300 | 1 | 0 |
| methapyrilene | Rattus norvegicus (Norway rat) | IC50 | 1.3910 | 1 | 0 |
| methapyrilene | Rattus norvegicus (Norway rat) | Ki | 1.3800 | 1 | 0 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 0.1630 | 1 | 0 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 0.1610 | 1 | 0 |
| miconazole | Rattus norvegicus (Norway rat) | IC50 | 2.9390 | 1 | 0 |
| miconazole | Rattus norvegicus (Norway rat) | Ki | 2.9150 | 1 | 0 |
| mitotane | Rattus norvegicus (Norway rat) | IC50 | 0.8190 | 1 | 0 |
| mitotane | Rattus norvegicus (Norway rat) | Ki | 0.8120 | 1 | 0 |
| mitoxantrone | Rattus norvegicus (Norway rat) | IC50 | 4.9898 | 1 | 0 |
| mitoxantrone | Rattus norvegicus (Norway rat) | Ki | 4.9485 | 1 | 0 |
| nabumetone | Rattus norvegicus (Norway rat) | IC50 | 1.8680 | 1 | 0 |
| nabumetone | Rattus norvegicus (Norway rat) | Ki | 1.8530 | 1 | 0 |
| nortriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.0032 | 1 | 0 |
| nortriptyline | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 0 |
| orphenadrine | Rattus norvegicus (Norway rat) | IC50 | 2.6660 | 1 | 0 |
| orphenadrine | Rattus norvegicus (Norway rat) | Ki | 2.6430 | 1 | 0 |
| oxybutynin | Rattus norvegicus (Norway rat) | IC50 | 2.5951 | 1 | 0 |
| oxybutynin | Rattus norvegicus (Norway rat) | Ki | 2.5737 | 1 | 0 |
| pentamidine | Rattus norvegicus (Norway rat) | IC50 | 2.2140 | 1 | 0 |
| pentamidine | Rattus norvegicus (Norway rat) | Ki | 2.1960 | 1 | 0 |
| perhexiline | Rattus norvegicus (Norway rat) | IC50 | 3.2942 | 1 | 0 |
| perhexiline | Rattus norvegicus (Norway rat) | Ki | 3.2670 | 1 | 0 |
| prochlorperazine | Rattus norvegicus (Norway rat) | IC50 | 0.4000 | 1 | 0 |
| prochlorperazine | Rattus norvegicus (Norway rat) | Ki | 0.3960 | 1 | 0 |
| promazine | Rattus norvegicus (Norway rat) | IC50 | 0.0130 | 1 | 0 |
| promazine | Rattus norvegicus (Norway rat) | Ki | 0.0130 | 1 | 0 |
| promethazine | Rattus norvegicus (Norway rat) | IC50 | 4.2380 | 1 | 0 |
| promethazine | Rattus norvegicus (Norway rat) | Ki | 4.2030 | 1 | 0 |
| propafenone | Rattus norvegicus (Norway rat) | IC50 | 3.0160 | 1 | 0 |
| propafenone | Rattus norvegicus (Norway rat) | Ki | 2.9910 | 1 | 0 |
| propofol | Rattus norvegicus (Norway rat) | IC50 | 9.3930 | 1 | 0 |
| propofol | Rattus norvegicus (Norway rat) | Ki | 9.3160 | 1 | 0 |
| raloxifene | Rattus norvegicus (Norway rat) | IC50 | 0.2820 | 1 | 0 |
| raloxifene | Rattus norvegicus (Norway rat) | Ki | 0.2800 | 1 | 0 |
| riluzole | Rattus norvegicus (Norway rat) | IC50 | 1.7330 | 1 | 0 |
| riluzole | Rattus norvegicus (Norway rat) | Ki | 1.7180 | 1 | 0 |
| sibutramine | Rattus norvegicus (Norway rat) | IC50 | 5.6650 | 1 | 0 |
| sibutramine | Rattus norvegicus (Norway rat) | Ki | 5.6190 | 1 | 0 |
| ponalrestat | Rattus norvegicus (Norway rat) | IC50 | 0.6160 | 4 | 4 |
| sulconazole | Rattus norvegicus (Norway rat) | IC50 | 2.0270 | 1 | 0 |
| sulconazole | Rattus norvegicus (Norway rat) | Ki | 2.0100 | 1 | 0 |
| terfenadine | Rattus norvegicus (Norway rat) | IC50 | 1.9280 | 1 | 0 |
| terfenadine | Rattus norvegicus (Norway rat) | Ki | 1.9120 | 1 | 0 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 1.5510 | 1 | 0 |
| thioridazine | Rattus norvegicus (Norway rat) | Ki | 1.5380 | 1 | 0 |
| venlafaxine | Rattus norvegicus (Norway rat) | IC50 | 2.7080 | 1 | 0 |
| venlafaxine | Rattus norvegicus (Norway rat) | Ki | 2.6850 | 1 | 0 |
| fr 74366 | Rattus norvegicus (Norway rat) | IC50 | 0.0044 | 1 | 1 |
| 2-acetylaminofluorene | Rattus norvegicus (Norway rat) | IC50 | 8.5950 | 1 | 0 |
| 2-acetylaminofluorene | Rattus norvegicus (Norway rat) | Ki | 8.5240 | 1 | 0 |
| ethinyl estradiol | Rattus norvegicus (Norway rat) | IC50 | 0.9590 | 1 | 0 |
| ethinyl estradiol | Rattus norvegicus (Norway rat) | Ki | 0.9510 | 1 | 0 |
| mepazine | Rattus norvegicus (Norway rat) | IC50 | 1.8770 | 1 | 0 |
| mepazine | Rattus norvegicus (Norway rat) | Ki | 1.8610 | 1 | 0 |
| mestranol | Rattus norvegicus (Norway rat) | IC50 | 1.3820 | 1 | 0 |
| mestranol | Rattus norvegicus (Norway rat) | Ki | 1.3710 | 1 | 0 |
| n,n'-diphenyl-4-phenylenediamine | Rattus norvegicus (Norway rat) | IC50 | 0.7860 | 1 | 0 |
| n,n'-diphenyl-4-phenylenediamine | Rattus norvegicus (Norway rat) | Ki | 0.7800 | 1 | 0 |
| bisphenol a | Rattus norvegicus (Norway rat) | IC50 | 16.6200 | 1 | 0 |
| bisphenol a | Rattus norvegicus (Norway rat) | Ki | 16.4830 | 1 | 0 |
| 1-naphthaleneacetic acid | Rattus norvegicus (Norway rat) | IC50 | 32.0000 | 2 | 2 |
| phenothiazine | Rattus norvegicus (Norway rat) | IC50 | 0.4610 | 1 | 0 |
| phenothiazine | Rattus norvegicus (Norway rat) | Ki | 0.4570 | 1 | 0 |
| diphenylguanidine | Rattus norvegicus (Norway rat) | IC50 | 1.1520 | 1 | 0 |
| diphenylguanidine | Rattus norvegicus (Norway rat) | Ki | 1.1430 | 1 | 0 |
| monobenzone | Rattus norvegicus (Norway rat) | IC50 | 3.8860 | 1 | 0 |
| monobenzone | Rattus norvegicus (Norway rat) | Ki | 3.8540 | 1 | 0 |
| benzethonium chloride | Rattus norvegicus (Norway rat) | IC50 | 0.9070 | 1 | 0 |
| benzethonium chloride | Rattus norvegicus (Norway rat) | Ki | 0.9000 | 1 | 0 |
| sterogenol | Rattus norvegicus (Norway rat) | IC50 | 2.6530 | 1 | 0 |
| sterogenol | Rattus norvegicus (Norway rat) | Ki | 2.6310 | 1 | 0 |
| catechin | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| dimenhydrinate | Rattus norvegicus (Norway rat) | IC50 | 2.0370 | 1 | 0 |
| dimenhydrinate | Rattus norvegicus (Norway rat) | Ki | 2.0200 | 1 | 0 |
| paeonol | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| ethylestrenol | Rattus norvegicus (Norway rat) | IC50 | 2.0980 | 1 | 0 |
| ethylestrenol | Rattus norvegicus (Norway rat) | Ki | 2.0800 | 1 | 0 |
| 4-octylphenol | Rattus norvegicus (Norway rat) | IC50 | 61.6470 | 1 | 0 |
| 4-octylphenol | Rattus norvegicus (Norway rat) | Ki | 61.1380 | 1 | 0 |
| 4-nitrohippuric acid | Rattus norvegicus (Norway rat) | IC50 | 280.0000 | 1 | 1 |
| 4-chlorohippuric acid | Rattus norvegicus (Norway rat) | IC50 | 550.0000 | 1 | 1 |
| clemastine | Rattus norvegicus (Norway rat) | IC50 | 3.0860 | 1 | 0 |
| clemastine | Rattus norvegicus (Norway rat) | Ki | 3.0600 | 1 | 0 |
| danazol | Rattus norvegicus (Norway rat) | IC50 | 5.6980 | 1 | 0 |
| danazol | Rattus norvegicus (Norway rat) | Ki | 5.6510 | 1 | 0 |
| metergoline | Rattus norvegicus (Norway rat) | IC50 | 0.3660 | 1 | 0 |
| metergoline | Rattus norvegicus (Norway rat) | Ki | 0.3630 | 1 | 0 |
| pedalitin | Rattus norvegicus (Norway rat) | IC50 | 0.3020 | 1 | 1 |
| dexchlorpheniramine | Rattus norvegicus (Norway rat) | IC50 | 4.9660 | 1 | 0 |
| dexchlorpheniramine | Rattus norvegicus (Norway rat) | Ki | 4.9250 | 1 | 0 |
| dobutamine | Rattus norvegicus (Norway rat) | IC50 | 0.3830 | 1 | 0 |
| dobutamine | Rattus norvegicus (Norway rat) | Ki | 0.3800 | 1 | 0 |
| paroxetine | Rattus norvegicus (Norway rat) | IC50 | 0.0860 | 1 | 0 |
| paroxetine | Rattus norvegicus (Norway rat) | Ki | 0.0860 | 1 | 0 |
| lovastatin | Rattus norvegicus (Norway rat) | IC50 | 8.7530 | 1 | 0 |
| lovastatin | Rattus norvegicus (Norway rat) | Ki | 8.6800 | 1 | 0 |
| tolrestat | Rattus norvegicus (Norway rat) | IC50 | 11.3501 | 8 | 9 |
| nelfinavir | Rattus norvegicus (Norway rat) | IC50 | 8.8520 | 1 | 0 |
| nelfinavir | Rattus norvegicus (Norway rat) | Ki | 8.7790 | 1 | 0 |
| imirestat | Rattus norvegicus (Norway rat) | IC50 | 0.0070 | 2 | 2 |
| sertraline | Rattus norvegicus (Norway rat) | IC50 | 0.9848 | 1 | 0 |
| sertraline | Rattus norvegicus (Norway rat) | Ki | 0.9766 | 1 | 0 |
| n-4-tosylglycine | Rattus norvegicus (Norway rat) | IC50 | 32.0000 | 1 | 1 |
| epicatechin | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| gallocatechol | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| beta-amyrin | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| tingenin b | Rattus norvegicus (Norway rat) | IC50 | 7.0000 | 1 | 1 |
| xanthomicrol | Rattus norvegicus (Norway rat) | IC50 | 0.5370 | 1 | 1 |
| n-methylhippuric acid | Rattus norvegicus (Norway rat) | IC50 | 23.0000 | 1 | 1 |
| tetramethylene glutaric acid | Rattus norvegicus (Norway rat) | IC50 | 30.2500 | 2 | 2 |
| indole-1-acetic acid | Rattus norvegicus (Norway rat) | IC50 | 7.3000 | 1 | 1 |
| 9-fluoreneacetic acid | Rattus norvegicus (Norway rat) | IC50 | 8.9000 | 1 | 1 |
| 4-methylhippuric acid | Rattus norvegicus (Norway rat) | IC50 | 220.0000 | 1 | 1 |
| tingenone | Rattus norvegicus (Norway rat) | IC50 | 13.0000 | 1 | 1 |
| u 69593 | Rattus norvegicus (Norway rat) | Ki | 1.1450 | 1 | 2 |
| al-01567 | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 1 |
| valdecoxib | Rattus norvegicus (Norway rat) | IC50 | 2.9270 | 1 | 0 |
| valdecoxib | Rattus norvegicus (Norway rat) | Ki | 2.9030 | 1 | 0 |
| desloratadine | Rattus norvegicus (Norway rat) | IC50 | 1.1160 | 1 | 0 |
| desloratadine | Rattus norvegicus (Norway rat) | Ki | 1.1070 | 1 | 0 |
| 4-methyoxybenzoyl-n-glycine | Rattus norvegicus (Norway rat) | IC50 | 71.0000 | 1 | 1 |
| 2-naphthoylglycine | Rattus norvegicus (Norway rat) | IC50 | 55.0000 | 2 | 2 |
| n-(((4-benzoylamino)phenyl)sulfonyl)glycine | Rattus norvegicus (Norway rat) | IC50 | 0.6450 | 2 | 2 |
| sideritoflavone | Rattus norvegicus (Norway rat) | IC50 | 0.0389 | 1 | 1 |
| lidorestat | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| fidarestat | Rattus norvegicus (Norway rat) | IC50 | 0.0330 | 3 | 3 |
| cirsiliol | Rattus norvegicus (Norway rat) | IC50 | 0.1698 | 1 | 1 |
| isolariciresinol | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| nevadensin | Rattus norvegicus (Norway rat) | IC50 | 7.2444 | 1 | 1 |
| cirsilineol | Rattus norvegicus (Norway rat) | IC50 | 6.7608 | 1 | 1 |
| tanshinone ii a | Rattus norvegicus (Norway rat) | IC50 | 1.1400 | 2 | 2 |
| maytenonic acid | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| 4',5-dihydroxy-3',6,7,8-tetramethoxyflavone | Rattus norvegicus (Norway rat) | IC50 | 45.7088 | 1 | 1 |
| 4',6-dihydroxyflavone | Rattus norvegicus (Norway rat) | IC50 | 5.2481 | 1 | 1 |
| cirsimaritin | Rattus norvegicus (Norway rat) | IC50 | 1.4125 | 1 | 1 |
| ad 5467 | Rattus norvegicus (Norway rat) | IC50 | 0.1300 | 1 | 1 |
| n-(phenylsulfonyl)glycine | Rattus norvegicus (Norway rat) | IC50 | 132.0000 | 2 | 2 |
| estradiol 3-benzoate | Rattus norvegicus (Norway rat) | IC50 | 17.2290 | 1 | 0 |
| estradiol 3-benzoate | Rattus norvegicus (Norway rat) | Ki | 17.0870 | 1 | 0 |
| sorbinil | Rattus norvegicus (Norway rat) | IC50 | 0.8698 | 24 | 25 |
| 7-methoxycoumarin-4-acetic acid | Rattus norvegicus (Norway rat) | IC50 | 0.3700 | 1 | 1 |
| terconazole | Rattus norvegicus (Norway rat) | IC50 | 25.3910 | 1 | 0 |
| terconazole | Rattus norvegicus (Norway rat) | Ki | 25.1820 | 1 | 0 |
| resveratrol | Rattus norvegicus (Norway rat) | IC50 | 13.6560 | 2 | 1 |
| resveratrol | Rattus norvegicus (Norway rat) | Ki | 2.2930 | 1 | 0 |
| diethylstilbestrol | Rattus norvegicus (Norway rat) | IC50 | 3.6700 | 1 | 0 |
| diethylstilbestrol | Rattus norvegicus (Norway rat) | Ki | 3.6400 | 1 | 0 |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | Rattus norvegicus (Norway rat) | IC50 | 1.4004 | 1 | 0 |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | Rattus norvegicus (Norway rat) | Ki | 1.3888 | 1 | 0 |
| flunarizine | Rattus norvegicus (Norway rat) | IC50 | 1.3390 | 1 | 0 |
| flunarizine | Rattus norvegicus (Norway rat) | Ki | 1.3280 | 1 | 0 |
| benztropine | Rattus norvegicus (Norway rat) | IC50 | 1.3910 | 1 | 0 |
| benztropine | Rattus norvegicus (Norway rat) | Ki | 1.3790 | 1 | 0 |
| 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | Rattus norvegicus (Norway rat) | IC50 | 12.0310 | 1 | 1 |
| cinnarizine | Rattus norvegicus (Norway rat) | IC50 | 2.8320 | 1 | 0 |
| cinnarizine | Rattus norvegicus (Norway rat) | Ki | 2.8080 | 1 | 0 |
| enclomiphene | Rattus norvegicus (Norway rat) | IC50 | 0.8620 | 1 | 0 |
| enclomiphene | Rattus norvegicus (Norway rat) | Ki | 0.8550 | 1 | 0 |
| terbinafine | Rattus norvegicus (Norway rat) | IC50 | 4.1295 | 1 | 0 |
| terbinafine | Rattus norvegicus (Norway rat) | Ki | 4.0954 | 1 | 0 |
| epalrestat | Rattus norvegicus (Norway rat) | IC50 | 0.5596 | 28 | 28 |
| chlorogenic acid | Rattus norvegicus (Norway rat) | IC50 | 0.9500 | 1 | 1 |
| tamoxifen | Rattus norvegicus (Norway rat) | IC50 | 1.4720 | 1 | 0 |
| tamoxifen | Rattus norvegicus (Norway rat) | Ki | 1.4590 | 1 | 0 |
| Benzo[E]pyrazolo[5,1-c][1,2,4]triazin-8-yl N,N-dimethylcarbamate | Rattus norvegicus (Norway rat) | IC50 | 38.7000 | 1 | 1 |
| u-50488 | Rattus norvegicus (Norway rat) | Ki | 0.2900 | 1 | 2 |
| vx-745 | Rattus norvegicus (Norway rat) | IC50 | 20.4040 | 1 | 0 |
| vx-745 | Rattus norvegicus (Norway rat) | Ki | 20.2360 | 1 | 0 |
| demethoxysudachitin | Rattus norvegicus (Norway rat) | IC50 | 0.4074 | 1 | 1 |
| eugenyl-beta-d-glucopyranoside | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| bw 723c86 | Rattus norvegicus (Norway rat) | IC50 | 3.6257 | 1 | 0 |
| bw 723c86 | Rattus norvegicus (Norway rat) | Ki | 3.5957 | 1 | 0 |
| quercetin | Rattus norvegicus (Norway rat) | IC50 | 6.6417 | 5 | 6 |
| apigenin | Rattus norvegicus (Norway rat) | IC50 | 6.6700 | 1 | 1 |
| luteolin | Rattus norvegicus (Norway rat) | IC50 | 1.5400 | 1 | 1 |
| quercitrin | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 2 | 3 |
| hymecromone | Rattus norvegicus (Norway rat) | IC50 | 62.0000 | 1 | 1 |
| dexmedetomidine | Rattus norvegicus (Norway rat) | IC50 | 0.3483 | 1 | 1 |
| quercetin 3-o-glucopyranoside | Rattus norvegicus (Norway rat) | IC50 | 4.4000 | 1 | 1 |
| rutin | Rattus norvegicus (Norway rat) | IC50 | 13.0000 | 1 | 1 |
| kaempferol | Rattus norvegicus (Norway rat) | IC50 | 1.3300 | 1 | 1 |
| montelukast | Rattus norvegicus (Norway rat) | IC50 | 2.6890 | 1 | 0 |
| montelukast | Rattus norvegicus (Norway rat) | Ki | 2.6670 | 1 | 0 |
| spinasterol | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| axillarin | Rattus norvegicus (Norway rat) | IC50 | 0.0280 | 1 | 1 |
| 6-hydroxyluteolin | Rattus norvegicus (Norway rat) | IC50 | 0.2042 | 1 | 1 |
| mangiferin | Rattus norvegicus (Norway rat) | IC50 | 3.2000 | 1 | 1 |
| polydatin | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| caffeic acid phenethyl ester | Rattus norvegicus (Norway rat) | IC50 | 3.7870 | 1 | 0 |
| caffeic acid phenethyl ester | Rattus norvegicus (Norway rat) | Ki | 3.7560 | 1 | 0 |
| astragalin | Rattus norvegicus (Norway rat) | IC50 | 5.0900 | 1 | 1 |
| lacidipine | Rattus norvegicus (Norway rat) | IC50 | 5.7350 | 1 | 0 |
| lacidipine | Rattus norvegicus (Norway rat) | Ki | 5.6870 | 1 | 0 |
| 3',4'-didemethylnobiletin | Rattus norvegicus (Norway rat) | IC50 | 0.0324 | 1 | 1 |
| isorhamnetin 3-o-glucoside | Rattus norvegicus (Norway rat) | IC50 | 8.3500 | 1 | 2 |
| kaempferol-3-o-rutinoside | Rattus norvegicus (Norway rat) | IC50 | 11.3000 | 1 | 1 |
| apigenin-7-o-beta-d-glucuronide | Rattus norvegicus (Norway rat) | IC50 | 1.2800 | 1 | 1 |
| 7-hydroxycoumarin-4-acetic acid | Rattus norvegicus (Norway rat) | IC50 | 0.1500 | 1 | 1 |
| oxiconazole | Rattus norvegicus (Norway rat) | IC50 | 1.9103 | 1 | 0 |
| oxiconazole | Rattus norvegicus (Norway rat) | Ki | 1.8945 | 1 | 0 |
| 5,7-dihydroxy-4-methylcoumarin | Rattus norvegicus (Norway rat) | IC50 | 17.0000 | 1 | 1 |
| 7,8-dihydroxy-4-methylcoumarin | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| guajavarin | Rattus norvegicus (Norway rat) | IC50 | 0.3200 | 1 | 1 |
| narcissin flavonol | Rattus norvegicus (Norway rat) | IC50 | 12.1000 | 1 | 1 |
| lyoniside | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| 4,5-di-O-caffeoylquinic acid | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| indigo carmine | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 1 |
| gw 1929 | Rattus norvegicus (Norway rat) | IC50 | 40.3080 | 1 | 0 |
| gw 1929 | Rattus norvegicus (Norway rat) | Ki | 39.9750 | 1 | 0 |
| rwj 68354 | Rattus norvegicus (Norway rat) | IC50 | 1.0700 | 1 | 0 |
| rwj 68354 | Rattus norvegicus (Norway rat) | Ki | 1.0610 | 1 | 0 |
| palbinone | Rattus norvegicus (Norway rat) | IC50 | 11.4000 | 1 | 1 |
| vaticanol b | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| oc000459 | Rattus norvegicus (Norway rat) | IC50 | 0.5500 | 1 | 1 |
| lyoniresinol | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| sudachitin | Rattus norvegicus (Norway rat) | IC50 | 4.4668 | 1 | 1 |
| valproate sodium | Rattus norvegicus (Norway rat) | IC50 | 380.0000 | 1 | 1 |
| 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone | Rattus norvegicus (Norway rat) | IC50 | 18.6209 | 1 | 1 |
| triptotriterpenic acid a | Rattus norvegicus (Norway rat) | IC50 | 72.0000 | 1 | 1 |
| pf 750 | Rattus norvegicus (Norway rat) | IC50 | 1.0900 | 1 | 1 |
| malibatol a | Rattus norvegicus (Norway rat) | IC50 | 35.6000 | 1 | 1 |
| peoniflorin | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| benzoylpaeoniflorin | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| galloylpaeoniflorin | Rattus norvegicus (Norway rat) | IC50 | 44.6000 | 1 | 1 |
| vaticanol c | Rattus norvegicus (Norway rat) | IC50 | 21.2000 | 1 | 1 |
| ethyl 1-benzyl-3-hydroxy-2(5h)-oxopyrrole-4-carboxylate | Rattus norvegicus (Norway rat) | IC50 | 5.3598 | 5 | 6 |
| 3-(2-((cyclobutylmethyl)(phenethyl)amino)ethyl)phenol | Rattus norvegicus (Norway rat) | Ki | 0.5420 | 1 | 2 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 1.4700 | 1 | 0 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 1.4580 | 1 | 0 |