Page last updated: 2024-08-07 16:56:16
Mu-type opioid receptor
[no definition available]
Synonyms
M-OR-1;
MOR-1
Research
Bioassay Publications (142)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 7 (4.93) | 18.7374 |
| 1990's | 36 (25.35) | 18.2507 |
| 2000's | 60 (42.25) | 29.6817 |
| 2010's | 37 (26.06) | 24.3611 |
| 2020's | 2 (1.41) | 2.80 |
Compounds (188)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bremazocine | Cavia porcellus (domestic guinea pig) | IC50 | 0.0018 | 1 | 1 |
| acetazolamide | Cavia porcellus (domestic guinea pig) | Ki | 0.1707 | 3 | 3 |
| celecoxib | Cavia porcellus (domestic guinea pig) | IC50 | 7.7000 | 1 | 1 |
| celecoxib | Cavia porcellus (domestic guinea pig) | Ki | 0.0210 | 1 | 1 |
| cgs 15943 | Cavia porcellus (domestic guinea pig) | Ki | 0.0004 | 1 | 1 |
| clonidine | Cavia porcellus (domestic guinea pig) | Ki | 0.0141 | 1 | 1 |
| dichlorphenamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0380 | 1 | 1 |
| ethoxzolamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0080 | 1 | 1 |
| fentanyl | Cavia porcellus (domestic guinea pig) | IC50 | 0.0031 | 1 | 2 |
| fentanyl | Cavia porcellus (domestic guinea pig) | Ki | 0.0059 | 1 | 1 |
| hydrochlorothiazide | Cavia porcellus (domestic guinea pig) | Ki | 0.2900 | 1 | 1 |
| ibuprofen | Cavia porcellus (domestic guinea pig) | IC50 | 2.9000 | 1 | 1 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | Cavia porcellus (domestic guinea pig) | IC50 | 1.6000 | 1 | 1 |
| mafenide | Cavia porcellus (domestic guinea pig) | Ki | 0.1700 | 1 | 1 |
| meperidine | Cavia porcellus (domestic guinea pig) | IC50 | 0.5000 | 1 | 1 |
| methazolamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0140 | 1 | 1 |
| pentazocine | Cavia porcellus (domestic guinea pig) | Ki | 0.0054 | 1 | 1 |
| moxonidine | Cavia porcellus (domestic guinea pig) | Ki | 0.0778 | 1 | 1 |
| rofecoxib | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| saccharin | Cavia porcellus (domestic guinea pig) | Ki | 5.9590 | 1 | 1 |
| sulfanilamide | Cavia porcellus (domestic guinea pig) | Ki | 0.2400 | 1 | 1 |
| sulpiride | Cavia porcellus (domestic guinea pig) | Ki | 0.0400 | 1 | 1 |
| sulthiame | Cavia porcellus (domestic guinea pig) | Ki | 0.0090 | 1 | 1 |
| trimethoprim | Cavia porcellus (domestic guinea pig) | IC50 | 2.8000 | 1 | 1 |
| whi p180 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0500 | 1 | 1 |
| zonisamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0350 | 1 | 1 |
| 4-toluenesulfonamide | Cavia porcellus (domestic guinea pig) | Ki | 0.3200 | 1 | 1 |
| phenidone | Cavia porcellus (domestic guinea pig) | IC50 | 0.4200 | 1 | 1 |
| 1,3-ditolylguanidine | Cavia porcellus (domestic guinea pig) | Ki | 0.0710 | 1 | 2 |
| carzenide | Cavia porcellus (domestic guinea pig) | Ki | 0.0460 | 1 | 1 |
| glycyl-glycyl-glycine | Cavia porcellus (domestic guinea pig) | IC50 | 1,070.0000 | 1 | 1 |
| glycylglycine | Cavia porcellus (domestic guinea pig) | IC50 | 820.0000 | 1 | 1 |
| Berberine chloride (TN) | Cavia porcellus (domestic guinea pig) | IC50 | 9.2920 | 2 | 2 |
| benzolamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0090 | 1 | 1 |
| alfentanil | Cavia porcellus (domestic guinea pig) | IC50 | 0.0150 | 1 | 2 |
| tolrestat | Cavia porcellus (domestic guinea pig) | IC50 | 0.0300 | 1 | 1 |
| piritrexim | Cavia porcellus (domestic guinea pig) | IC50 | 0.0043 | 1 | 1 |
| spiradoline | Cavia porcellus (domestic guinea pig) | Ki | 1.6715 | 3 | 8 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0750 | 1 | 1 |
| disulphane | Cavia porcellus (domestic guinea pig) | Ki | 0.0460 | 1 | 1 |
| rilmenidine | Cavia porcellus (domestic guinea pig) | Ki | 0.0831 | 1 | 1 |
| brinzolamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0030 | 1 | 1 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Cavia porcellus (domestic guinea pig) | Ki | 0.0630 | 1 | 1 |
| tyrosyltyrosine | Cavia porcellus (domestic guinea pig) | IC50 | 60.0000 | 1 | 1 |
| leucylleucine | Cavia porcellus (domestic guinea pig) | IC50 | 170.0000 | 1 | 1 |
| rosiglitazone | Cavia porcellus (domestic guinea pig) | IC50 | 0.0380 | 1 | 1 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0600 | 1 | 1 |
| phenylalanylphenylalanylamide | Cavia porcellus (domestic guinea pig) | IC50 | 80.0000 | 1 | 1 |
| Trp-Trp | Cavia porcellus (domestic guinea pig) | IC50 | 250.0000 | 1 | 1 |
| nicotine | Cavia porcellus (domestic guinea pig) | Ki | 0.2260 | 2 | 2 |
| glycyltryptophan | Cavia porcellus (domestic guinea pig) | IC50 | 520.0000 | 1 | 1 |
| glycyltyrosine | Cavia porcellus (domestic guinea pig) | IC50 | 120.0000 | 1 | 1 |
| glycylleucine | Cavia porcellus (domestic guinea pig) | IC50 | 70.0000 | 1 | 1 |
| alanyltyrosine | Cavia porcellus (domestic guinea pig) | IC50 | 170.0000 | 1 | 1 |
| glycyl-l-phenylalanine | Cavia porcellus (domestic guinea pig) | IC50 | 170.0000 | 1 | 1 |
| glycylsarcosine | Cavia porcellus (domestic guinea pig) | IC50 | 1,160.0000 | 1 | 1 |
| alanylphenylalanine | Cavia porcellus (domestic guinea pig) | IC50 | 70.0000 | 1 | 1 |
| tryptophylglycine | Cavia porcellus (domestic guinea pig) | IC50 | 730.0000 | 1 | 1 |
| glycylaspartic acid | Cavia porcellus (domestic guinea pig) | IC50 | 380.0000 | 1 | 1 |
| n-glycylglutamic acid | Cavia porcellus (domestic guinea pig) | IC50 | 650.0000 | 1 | 1 |
| histidylglycine | Cavia porcellus (domestic guinea pig) | IC50 | 340.0000 | 1 | 1 |
| enkephalin, d-penicillamine (2,5)- | Cavia porcellus (domestic guinea pig) | Ki | 0.0017 | 1 | 1 |
| sr141716 | Cavia porcellus (domestic guinea pig) | IC50 | 0.1080 | 1 | 1 |
| u 69593 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5880 | 2 | 3 |
| u 69593 | Cavia porcellus (domestic guinea pig) | Ki | 0.2464 | 5 | 11 |
| valylvaline | Cavia porcellus (domestic guinea pig) | IC50 | 210.0000 | 1 | 1 |
| tifluadom | Cavia porcellus (domestic guinea pig) | Ki | 0.0019 | 1 | 1 |
| valdecoxib | Cavia porcellus (domestic guinea pig) | Ki | 0.0430 | 1 | 1 |
| tyrosyl-arginyl-phenylalanyl-lysinamide | Cavia porcellus (domestic guinea pig) | IC50 | 0.2540 | 1 | 1 |
| 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| dermorphin, arg(2)- | Cavia porcellus (domestic guinea pig) | IC50 | 0.0900 | 1 | 1 |
| 2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide | Cavia porcellus (domestic guinea pig) | IC50 | 1.7990 | 1 | 3 |
| glycyl-leucyl-phenylalanine | Cavia porcellus (domestic guinea pig) | IC50 | 980.0000 | 1 | 1 |
| lysyllysine | Cavia porcellus (domestic guinea pig) | IC50 | 10,900.0000 | 1 | 1 |
| 2-(4-morpholinyl)-4h-1-benzopyran-4-one | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan | Cavia porcellus (domestic guinea pig) | IC50 | 0.3981 | 1 | 1 |
| 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan | Cavia porcellus (domestic guinea pig) | Ki | 0.1340 | 1 | 1 |
| ly 99335, (3r-cis)-isomer | Cavia porcellus (domestic guinea pig) | Ki | 0.0800 | 1 | 1 |
| ly 106737 | Cavia porcellus (domestic guinea pig) | Ki | 0.0015 | 1 | 1 |
| aspartylglycine | Cavia porcellus (domestic guinea pig) | IC50 | 810.0000 | 1 | 1 |
| arginylarginine | Cavia porcellus (domestic guinea pig) | IC50 | 7,310.0000 | 1 | 1 |
| enkephalin, pen(2,5)-4-chloro-phe(4)- | Cavia porcellus (domestic guinea pig) | Ki | 0.1800 | 1 | 1 |
| n-valyltryptophan | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Cavia porcellus (domestic guinea pig) | Ki | 0.1600 | 1 | 1 |
| varenicline | Cavia porcellus (domestic guinea pig) | Ki | 0.1952 | 2 | 2 |
| zm 241385 | Cavia porcellus (domestic guinea pig) | Ki | 0.0008 | 1 | 1 |
| sch 58261 | Cavia porcellus (domestic guinea pig) | Ki | 0.0006 | 1 | 1 |
| prolylglutamic acid | Cavia porcellus (domestic guinea pig) | IC50 | 12,300.0000 | 1 | 1 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0150 | 1 | 1 |
| sorbinil | Cavia porcellus (domestic guinea pig) | IC50 | 1.1000 | 1 | 1 |
| halenaquinone | Cavia porcellus (domestic guinea pig) | IC50 | 3.7000 | 1 | 1 |
| glutamyl-glutamic acid | Cavia porcellus (domestic guinea pig) | IC50 | 620.0000 | 1 | 1 |
| davidigenin | Cavia porcellus (domestic guinea pig) | IC50 | 1,000.0000 | 1 | 1 |
| enkephalin, methionine | Cavia porcellus (domestic guinea pig) | Ki | 0.0069 | 1 | 1 |
| enkephalin, leucine | Cavia porcellus (domestic guinea pig) | IC50 | 0.2460 | 1 | 1 |
| enkephalin, leucine | Cavia porcellus (domestic guinea pig) | Ki | 0.3800 | 1 | 1 |
| aspartyl-aspartic acid | Cavia porcellus (domestic guinea pig) | IC50 | 630.0000 | 1 | 1 |
| n-glycylalanine | Cavia porcellus (domestic guinea pig) | IC50 | 1,820.0000 | 1 | 1 |
| glycylproline | Cavia porcellus (domestic guinea pig) | IC50 | 330.0000 | 1 | 1 |
| mitragynine | Cavia porcellus (domestic guinea pig) | Ki | 0.0072 | 1 | 1 |
| u-50488 | Cavia porcellus (domestic guinea pig) | Ki | 0.5226 | 6 | 13 |
| ketazocine | Cavia porcellus (domestic guinea pig) | Ki | 0.0033 | 1 | 1 |
| glycyllysine | Cavia porcellus (domestic guinea pig) | IC50 | 1,250.0000 | 1 | 1 |
| ici 199441 | Cavia porcellus (domestic guinea pig) | Ki | 0.0001 | 1 | 1 |
| 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine | Cavia porcellus (domestic guinea pig) | Ki | 0.1140 | 1 | 1 |
| benzene-1-3-disulfonamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0080 | 1 | 1 |
| mangostin | Cavia porcellus (domestic guinea pig) | IC50 | 0.5800 | 1 | 1 |
| dorzolamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0090 | 1 | 1 |
| naloxone | Cavia porcellus (domestic guinea pig) | IC50 | 0.0089 | 1 | 1 |
| naloxone | Cavia porcellus (domestic guinea pig) | Ki | 0.0017 | 2 | 2 |
| oxymorphone | Cavia porcellus (domestic guinea pig) | Ki | 0.0150 | 1 | 1 |
| topiramate | Cavia porcellus (domestic guinea pig) | Ki | 0.0100 | 1 | 1 |
| morphine | Cavia porcellus (domestic guinea pig) | IC50 | 0.2020 | 4 | 4 |
| morphine | Cavia porcellus (domestic guinea pig) | Ki | 0.0413 | 15 | 24 |
| su 5402 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0200 | 1 | 1 |
| 7-benzylidenenaltrexone | Cavia porcellus (domestic guinea pig) | Ki | 0.0260 | 1 | 2 |
| endomorphin 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0046 | 1 | 2 |
| j 113397 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0023 | 1 | 2 |
| semaxinib | Cavia porcellus (domestic guinea pig) | IC50 | 0.2000 | 1 | 1 |
| su 11248 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0180 | 1 | 1 |
| levorphanol | Cavia porcellus (domestic guinea pig) | IC50 | 0.0006 | 1 | 2 |
| levorphanol | Cavia porcellus (domestic guinea pig) | Ki | 0.0002 | 1 | 1 |
| cyclorphan | Cavia porcellus (domestic guinea pig) | Ki | 0.0001 | 1 | 1 |
| naltrexone | Cavia porcellus (domestic guinea pig) | IC50 | 0.0004 | 3 | 3 |
| naltrexone | Cavia porcellus (domestic guinea pig) | Ki | 0.0011 | 16 | 21 |
| n-methylnaltrindole | Cavia porcellus (domestic guinea pig) | Ki | 0.0392 | 1 | 1 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Cavia porcellus (domestic guinea pig) | IC50 | 0.0283 | 1 | 1 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Cavia porcellus (domestic guinea pig) | Ki | 0.0009 | 3 | 3 |
| norbinaltorphimine | Cavia porcellus (domestic guinea pig) | Ki | 0.0173 | 12 | 19 |
| alanylalanine | Cavia porcellus (domestic guinea pig) | IC50 | 250.0000 | 1 | 1 |
| dermorphin | Cavia porcellus (domestic guinea pig) | IC50 | 0.0026 | 3 | 3 |
| 6 beta-hydroxynaltrexone | Cavia porcellus (domestic guinea pig) | IC50 | 0.0013 | 2 | 3 |
| 14-methoxymetopon | Cavia porcellus (domestic guinea pig) | Ki | 0.3040 | 1 | 1 |
| biphalin | Cavia porcellus (domestic guinea pig) | IC50 | 0.0025 | 1 | 1 |
| biphalin | Cavia porcellus (domestic guinea pig) | Ki | 0.0014 | 1 | 2 |
| phenylalanylalanine | Cavia porcellus (domestic guinea pig) | IC50 | 70.0000 | 1 | 1 |
| alanyltyrosine | Cavia porcellus (domestic guinea pig) | IC50 | 110.0000 | 1 | 1 |
| naltrindole | Cavia porcellus (domestic guinea pig) | Ki | 0.0104 | 10 | 15 |
| prolylglycine | Cavia porcellus (domestic guinea pig) | IC50 | 16,000.0000 | 1 | 1 |
| arginyllysine | Cavia porcellus (domestic guinea pig) | IC50 | 8,110.0000 | 1 | 1 |
| manoalide | Cavia porcellus (domestic guinea pig) | IC50 | 0.5000 | 1 | 1 |
| 7-benzylidenenaltrexone | Cavia porcellus (domestic guinea pig) | Ki | 0.0330 | 1 | 2 |
| (2E,4E)-N-isobutyl-2,4-dodecadienamide | Cavia porcellus (domestic guinea pig) | Ki | 0.0520 | 1 | 1 |
| trk 820 | Cavia porcellus (domestic guinea pig) | Ki | 0.0006 | 2 | 2 |
| clocinnamox | Cavia porcellus (domestic guinea pig) | Ki | 0.0027 | 1 | 1 |
| vilazodone | Cavia porcellus (domestic guinea pig) | IC50 | 0.0003 | 1 | 1 |
| phenylalanylglycine | Cavia porcellus (domestic guinea pig) | IC50 | 170.0000 | 1 | 1 |
| histidylhistidine | Cavia porcellus (domestic guinea pig) | IC50 | 400.0000 | 1 | 1 |
| lysylglutamic acid | Cavia porcellus (domestic guinea pig) | IC50 | 820.0000 | 1 | 1 |
| Ala-Lys | Cavia porcellus (domestic guinea pig) | IC50 | 280.0000 | 1 | 1 |
| valyl-valyl-valine | Cavia porcellus (domestic guinea pig) | IC50 | 230.0000 | 1 | 1 |
| lysylglycine | Cavia porcellus (domestic guinea pig) | IC50 | 380.0000 | 1 | 1 |
| glycylhistidine | Cavia porcellus (domestic guinea pig) | IC50 | 810.0000 | 1 | 1 |
| prolyl-serine | Cavia porcellus (domestic guinea pig) | IC50 | 16,000.0000 | 1 | 1 |
| sodium selenate | Cavia porcellus (domestic guinea pig) | Ki | 0.0002 | 1 | 1 |
| lu 28-179 | Cavia porcellus (domestic guinea pig) | Ki | 0.0170 | 1 | 1 |
| st 1535 | Cavia porcellus (domestic guinea pig) | Ki | 0.0066 | 1 | 1 |
| ly 255582 | Cavia porcellus (domestic guinea pig) | Ki | 0.0001 | 2 | 3 |
| dysidenin | Cavia porcellus (domestic guinea pig) | Ki | 9.0000 | 1 | 1 |
| deltorphin ii, ala(2)- | Cavia porcellus (domestic guinea pig) | Ki | 0.5000 | 1 | 2 |
| deltorphin i, ala(2)- | Cavia porcellus (domestic guinea pig) | Ki | 0.6770 | 1 | 3 |
| 8-carboxamidocyclazocine | Cavia porcellus (domestic guinea pig) | Ki | 0.0004 | 2 | 2 |
| snap 6201 | Cavia porcellus (domestic guinea pig) | Ki | 4.0000 | 2 | 3 |
| ufp-502 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0355 | 1 | 1 |
| 2-(2-fluoro-5-methylphenyl)-4,5-dihydro-1h-imidazole | Cavia porcellus (domestic guinea pig) | Ki | 0.0053 | 1 | 1 |
| PB28 | Cavia porcellus (domestic guinea pig) | Ki | 0.0004 | 1 | 1 |
| dynorphin a (1-11)-amide | Cavia porcellus (domestic guinea pig) | IC50 | 0.0099 | 2 | 4 |
| dynorphin a (1-11)-amide | Cavia porcellus (domestic guinea pig) | Ki | 0.0007 | 1 | 1 |
| h-dmt-tic-gly-nh-bzl | Cavia porcellus (domestic guinea pig) | Ki | 0.0000 | 1 | 1 |
| ki 8751 | Cavia porcellus (domestic guinea pig) | IC50 | 2.4000 | 1 | 1 |
| nu 7441 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0300 | 1 | 1 |
| adl 5859 | Cavia porcellus (domestic guinea pig) | IC50 | 78.0000 | 1 | 1 |
| prolyl-proline | Cavia porcellus (domestic guinea pig) | IC50 | 800.0000 | 1 | 1 |
| ku-0060648 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0050 | 1 | 1 |
| sazetidine-a | Cavia porcellus (domestic guinea pig) | Ki | 0.9500 | 2 | 2 |
| acyline | Cavia porcellus (domestic guinea pig) | IC50 | 0.0005 | 1 | 1 |
| azd1283 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0110 | 1 | 1 |
| halisulfate 1 | Cavia porcellus (domestic guinea pig) | IC50 | 12.6000 | 1 | 1 |
| a-922500 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0200 | 1 | 1 |
| dynorphins | Cavia porcellus (domestic guinea pig) | Ki | 0.0147 | 3 | 4 |
| 7-hydroxymitragynine | Cavia porcellus (domestic guinea pig) | Ki | 0.0114 | 2 | 2 |
| 7-spiroindanyloxymorphone | Cavia porcellus (domestic guinea pig) | Ki | 0.0106 | 2 | 4 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| loperamide | Cavia porcellus (domestic guinea pig) | EC50 | 0.0580 | 1 | 1 |
| estrone | Cavia porcellus (domestic guinea pig) | EC50 | 0.0080 | 1 | 1 |
| alpha-aminopyridine | Cavia porcellus (domestic guinea pig) | Kd | 4,000.0000 | 1 | 1 |
| 1,2-Dihydroquinolin-2-imine | Cavia porcellus (domestic guinea pig) | Kd | 125.0000 | 1 | 1 |
| captopril | Cavia porcellus (domestic guinea pig) | EC50 | 1,422.6600 | 1 | 1 |
| quinpirole | Cavia porcellus (domestic guinea pig) | EC50 | 0.0510 | 1 | 1 |
| spiradoline | Cavia porcellus (domestic guinea pig) | EC50 | 0.0180 | 1 | 1 |
| 1-aminoisoquinoline | Cavia porcellus (domestic guinea pig) | Kd | 650.0000 | 1 | 1 |
| u 69593 | Cavia porcellus (domestic guinea pig) | EC50 | 0.0077 | 1 | 1 |
| u 69593 | Cavia porcellus (domestic guinea pig) | Kd | 1.2672 | 4 | 5 |
| 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide | Cavia porcellus (domestic guinea pig) | Kd | 0.4950 | 4 | 4 |
| u-50488 | Cavia porcellus (domestic guinea pig) | EC50 | 0.0460 | 1 | 2 |
| naloxone | Cavia porcellus (domestic guinea pig) | Kd | 0.0002 | 1 | 1 |
| endomorphin 1 | Cavia porcellus (domestic guinea pig) | EC50 | 0.9320 | 1 | 1 |
| endomorphin 2 | Cavia porcellus (domestic guinea pig) | EC50 | 1.0000 | 1 | 1 |
| cyclorphan | Cavia porcellus (domestic guinea pig) | EC50 | 0.0002 | 1 | 2 |
| naltrexone | Cavia porcellus (domestic guinea pig) | EC50 | 0.0019 | 1 | 1 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Cavia porcellus (domestic guinea pig) | EC50 | 0.0325 | 5 | 8 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Cavia porcellus (domestic guinea pig) | Kd | 0.5920 | 2 | 3 |
| biphalin | Cavia porcellus (domestic guinea pig) | EC50 | 0.0011 | 2 | 3 |
| tyrosyl alanyl-glycyl-phenylalaninamide | Cavia porcellus (domestic guinea pig) | EC50 | 0.0117 | 1 | 2 |
| naltrindole | Cavia porcellus (domestic guinea pig) | EC50 | 0.0050 | 1 | 1 |
| trk 820 | Cavia porcellus (domestic guinea pig) | EC50 | 0.0006 | 1 | 1 |
| enkephalin, leucine-2-alanine | Cavia porcellus (domestic guinea pig) | EC50 | 0.0540 | 1 | 1 |
| sodium selenate | Cavia porcellus (domestic guinea pig) | EC50 | 0.0013 | 1 | 2 |
| 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinan | Cavia porcellus (domestic guinea pig) | Kd | 0.0000 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Cavia porcellus (domestic guinea pig) | EC50 | 0.0119 | 1 | 1 |
| deltorphin i, ala(2)- | Cavia porcellus (domestic guinea pig) | EC50 | 0.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nordazepam | Cavia porcellus (domestic guinea pig) | Activity | 17.0000 | 1 | 1 |
| u 69593 | Cavia porcellus (domestic guinea pig) | ED50 | 1.7775 | 2 | 4 |
| u 69593 | Cavia porcellus (domestic guinea pig) | Emax | 0.1703 | 4 | 6 |
| 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide | Cavia porcellus (domestic guinea pig) | ED50 | 0.5840 | 2 | 4 |
| 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide | Cavia porcellus (domestic guinea pig) | Emax | 0.1347 | 4 | 6 |
| 7-benzylidenenaltrexone | Cavia porcellus (domestic guinea pig) | Ke | 0.0083 | 1 | 2 |
| naltrexone | Cavia porcellus (domestic guinea pig) | Ke | 0.0010 | 3 | 4 |
| n-methylnaltrindole | Cavia porcellus (domestic guinea pig) | Ke | 0.0110 | 1 | 1 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Cavia porcellus (domestic guinea pig) | ED50 | 0.5920 | 1 | 1 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Cavia porcellus (domestic guinea pig) | Emax | 0.1230 | 2 | 2 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Cavia porcellus (domestic guinea pig) | pEC50 | 0.0074 | 1 | 1 |
| norbinaltorphimine | Cavia porcellus (domestic guinea pig) | Ke | 0.0148 | 8 | 10 |
| binaltorphimine | Cavia porcellus (domestic guinea pig) | Ke | 0.0110 | 1 | 1 |
| naltrexone hydrochloride | Cavia porcellus (domestic guinea pig) | Ke | 0.0011 | 2 | 2 |
| oxymorphindole | Cavia porcellus (domestic guinea pig) | Ke | 0.1110 | 1 | 1 |
| naltrindole | Cavia porcellus (domestic guinea pig) | Ke | 0.0309 | 4 | 7 |
| cyprodime | Cavia porcellus (domestic guinea pig) | Ke | 0.0286 | 2 | 2 |
| 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinan | Cavia porcellus (domestic guinea pig) | Ke | 0.0300 | 1 | 2 |
| ly 255582 | Cavia porcellus (domestic guinea pig) | Ke | 0.0000 | 1 | 2 |
| ici 174865 | Cavia porcellus (domestic guinea pig) | Ke | 1.6670 | 1 | 1 |
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Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.Journal of medicinal chemistry, , Aug-28, Volume: 46, Issue:18, 2003
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(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.Bioorganic & medicinal chemistry letters, , Oct-18, Volume: 9, Issue:20, 1999
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Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
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(1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
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3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
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(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Isothiocyanate-substituted benzyl ether opioid receptor ligands derived from 6 beta-naltrexol.Journal of medicinal chemistry, , Feb-03, Volume: 38, Issue:3, 1995
Synthesis and opioid receptor affinity of a series of aralkyl ethers of 6 alpha- and 6 beta-naltrexol.Journal of medicinal chemistry, , Dec-09, Volume: 37, Issue:25, 1994
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Design, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potent μ-opioid agonists.Journal of medicinal chemistry, , Apr-11, Volume: 56, Issue:7, 2013
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A high affinity, mu-opioid receptor-selective enkephalin analogue lacking an N-terminal tyrosine.Bioorganic & medicinal chemistry letters, , Oct-06, Volume: 8, Issue:19, 1998
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Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.Journal of medicinal chemistry, , 02-10, Volume: 65, Issue:3, 2022
[no title available]ACS medicinal chemistry letters, , Nov-09, Volume: 8, Issue:11, 2017
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Progress in the development of more effective and safer analgesics for pain management.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
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Potent and selective indolomorphinan antagonists of the kappa-opioid receptor.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
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