Lysyl oxidase homolog 4

A lysyl oxidase homolog 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96JB6]

EC 1.4.3.-;
Lysyl oxidase-like protein 4;
Lysyl oxidase-related protein C

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pyrithione	Homo sapiens (human)	IC50	15.0000	1	1
aminopropionitrile	Homo sapiens (human)	IC50	100.0000	1	1
disulfiram	Homo sapiens (human)	IC50	0.0590	1	1
thiram	Homo sapiens (human)	IC50	0.1800	1	1

This protein enables 3 target(s):

Target	Category	Definition
protein-lysine 6-oxidase activity	molecular function	Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. [EC:1.4.3.13]
copper ion binding	molecular function	Binding to a copper (Cu) ion. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

This protein is located in 2 target(s):

Target	Category	Definition
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 2 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
collagen-containing extracellular matrix	cellular component	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]

This protein is part of 1 target(s):

Target	Category	Definition
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

This protein is involved in 2 target(s):

Target	Category	Definition
collagen fibril organization	biological process	Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. [GOC:mah, ISBN:0815316194]
peptidyl-lysine oxidation	biological process	The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens. [ISBN:0198547684, RESID:AA0121]