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tremolite

Description

tremolite: see also actinolite; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	131634194
MeSH ID	M0047651

Synonyms (6)

Synonym
tremolite
tremolite asbestos
asbestos, tremolite
77536-68-6
qn851s6iry ,
abkhazite

Research Excerpts

Overview

Tremolite is an amphibole which has been implicated in a variety of disease patterns in different parts of the world. It is present in some chrysotile, talc, and vermiculite deposits.

Excerpt	Reference
"Tremolite is a noncommercial form of amphibole mineral that is present in some chrysotile, talc, and vermiculite deposits. "	( Evaluation of tremolite asbestos exposures associated with the use of commercial products. Adams, RE; Barlow, CA; Finley, BL; Paustenbach, DJ; Phelka, AD; Pierce, JS; Thuett, KA, 2012)
"Tremolite is an amphibole which has been implicated in a variety of disease patterns in different parts of the world. "	( Biological effects of tremolite. Berry, G; Brown, RC; Chamberlain, M; Davies, R; Griffiths, DM; Pooley, FD; Wagner, JC, 1982)

Effects

Tremolite contamination has been proposed as the cause of mesothelioma in workers exposed to commercial chrysotile. Tremolite has been associated with an increased risk of lung cancer in a study of vermiculite miners.

Excerpt	Reference
"Tremolite contamination has been proposed as the cause of mesothelioma in workers exposed to commercial chrysotile. "	( A case of occupational peritoneal mesothelioma from exposure to tremolite-free chrysotile in Quebec, Canada: A black swan case. Egilman, D; Menéndez, LM, 2011)
"Tremolite has been associated with an increased risk of lung cancer in a study of vermiculite miners; the slope of the exposure-response relationship was similar to that for crocidolite miners and much higher than that of chrysotile miners."	( Human evidence: lung cancer mortality risk from chrysotile exposure. Hughes, JM, 1994)

Treatment

Excerpt	Reference
"Rats treated with tremolite developed very high levels of pulmonary fibrosis as well as 16 carcinomas and two mesotheliomas in a group of 39 animals."	( Inhalation studies on the effects of tremolite and brucite dust in rats. Addison, J; Bolton, RE; Davis, JM; Donaldson, K; Jones, AD; Miller, BG, 1985)

Toxicity

Excerpt	Reference
" Despite weathered fibers appearing less toxic than "stored/laboratory" ones, NOA is to be considered far from safe because of fibrous nature and residual surface reactivity."	( The effect of weathering on ecopersistence, reactivity, and potential toxicity of naturally occurring asbestos and asbestiform minerals. Compagnoni, R; Enrico Favero-Longo, S; Fubini, B; Piervittori, R; Tomatis, M; Turci, F, 2009)
"Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals."	( Long-term toxicity of naturally occurring asbestos in male Fischer 344 rats. Cyphert, JM; Gavett, SH; Kodavanti, UP; McGee, MA; Nyska, A; Schladweiler, MC, 2016)

Dosage Studied

Excerpt	Reference
" The ambient dosage of asbestos has confirmed the existence of environmental pollution by chrysotile fibres and above all by tremolite."	( [Environmental mesotheliomas in northeast Corsica]. Billon-Galland, MA; Boutin, C; De Vuyst, P; Dumortier, P; Farisse, P; Hereng, P; Rey, F; Viallat, JR, 1993)
" Our study reveals the critical nature of EMP morphometric parameters for exposure assessment and dosing approaches used in toxicity studies."	( Differential responses of murine alveolar macrophages to elongate mineral particles of asbestiform and non-asbestiform varieties: Cytotoxicity, cytokine secretion and transcriptional changes. Guppi, S; Khaliullin, TO; Kisin, ER; Shvedova, AA; Yanamala, N; Zhernovkov, V, 2020)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (192)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	37 (19.27)	18.7374
1990's	47 (24.48)	18.2507
2000's	47 (24.48)	29.6817
2010's	46 (23.96)	24.3611
2020's	15 (7.81)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (0.49%)	5.53%
Reviews	14 (6.90%)	6.00%
Case Studies	15 (7.39%)	4.05%
Observational	1 (0.49%)	0.25%
Other	172 (84.73%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.41	1	0	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	2.08	1	0	metal allergen; nickel group element atom	epitope; micronutrient
nitrites Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)	2.03	1	0	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species	human metabolite
oxalic acid Oxalic Acid: A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.. oxalic acid : An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.	2.05	1	0	alpha,omega-dicarboxylic acid	algal metabolite; human metabolite; plant metabolite
1,2-dimethylhydrazine 1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.. 1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.	1.96	1	0	hydrazines	alkylating agent; carcinogenic agent
methacholine chloride Methacholine Chloride: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)	2.13	1	0	quaternary ammonium salt
phencyclidine Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.	3.85	12	0	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug
nitrilotriacetic acid Nitrilotriacetic Acid: A derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.)	2.1	1	0	NTA; tricarboxylic acid	carcinogenic agent; nephrotoxic agent
thiazoles [no description available]	2.08	1	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
limestone Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.. calcium carbonate : A calcium salt with formula CCaO3.	2.71	3	0	calcium salt; carbonate salt; inorganic calcium salt; one-carbon compound	antacid; fertilizer; food colouring; food firming agent
durapatite Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).	2.47	2	0
gamma-glycidoxypropyltrimethoxysilane 3-glycidyloxypropyltrimethoxysilane: used to immobilize carbonic anhydrase into mesoporous supports; structure in first source	2.21	1	0
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	2.73	3	0	titanium group element atom
tricalcium phosphate tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate Ca9(HPO4)(PO4)5(OH) is the calcium orthophosphate leading to beta tricalcium phosphate Ca3(PO4)2 (b-TCP). calcium phosphate : A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.	3	4	0	calcium phosphate
chrysotile Asbestos, Serpentine: A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)	9.5	68	1
titanium dioxide titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.	2.31	1	0	titanium oxides	food colouring
erionite erionite: erionite was SY to zeolite (NM); use zeolites (NM) to search through 1993; RN given is for cpd with unknown MF	4.53	7	0
dolomite calcium magnesium carbonate: mineral recommended by lay periodicals as a desirable source of calcium & magnesium, but found to be also a source of potentially toxic heavy metals	7.41	2	0
dimethylhydrazines Dimethylhydrazines: Hydrazines substituted with two methyl groups in any position.	1.96	1	0
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2.08	1	0	organic bromide salt	colorimetric reagent; dye
fibrinogen Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.	2.21	1	0	iditol	fungal metabolite
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	1.96	1	0	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	2.05	1	0	oxygen hydride; oxygen radical; reactive oxygen species
diopside [no description available]	2.03	1	0
phalloidine Phalloidine: Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage.. phalloidin : A homodetic bicyclic heptapeptide having a sulfide bridge.	2.08	1	0	homodetic cyclic peptide
lizardite [no description available]	2.08	1	0
strontium Strontium: An element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.	2.41	1	0	alkaline earth metal atom
arsenic Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	2.05	1	0	metalloid atom; pnictogen	micronutrient
zeolites [no description available]	4.73	9	0
silicate cement Silicate Cement: A relatively hard, translucent, restorative material used primarily in anterior teeth. (From Boucher's Clinical Dental Terminology, 4th ed, p50)	1.98	1	0
chitosan [no description available]	2.31	1	0
kaolinite Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: high ridge), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed). kaolin : An aluminosilicate soft white mineral named after the hill in China (Kao-ling) from which it was mined for centuries. In its natural state kaolin is a white, soft powder consisting principally of the mineral kaolinite, and varying amounts of other minerals such as muscovite, quartz, feldspar, and anatase. It is used in the manufacture of china and porcelain and also widely used in the production of paper, rubber, paint, drying agents, and many other products.	2	1	0	aluminosilicate mineral; mixture	antidiarrhoeal drug; excipient
ferroactinolite ferroactinolite: non-asbestos mineral fibers containing silicon, iron, calcium, magnesium, manganese in order of decreasing amount; RN given refers to cpd with unknown MF	4.33	19	0
asbestos, crocidolite Asbestos, Crocidolite: A lavender, acid-resistant asbestos.	7.15	16	1
feldspar feldspar: structure	2.13	1	0
asbestos, amosite Asbestos, Amosite: Asbestos, grunerite. A monoclinic amphibole form of asbestos having long fibers and a high iron content. It is used in insulation. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	6.56	15	1
vermiculite [no description available]	5.61	14	0

Condition	Relationship Strength	Studies	Trials
Malignant Mesothelioma [description not available]	9.59	8	0
Cancer of Lung [description not available]	9.29	49	1
Lung Neoplasms Tumors or cancer of the LUNG.	9.29	49	1
Mesothelioma A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)	8.34	77	0
Cancer of Ovary [description not available]	2.25	1	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.25	1	0
Diseases, Occupational [description not available]	8.29	37	0
Neoplasms, Pleural [description not available]	6.5	32	0
Asbestosis A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.	7.16	34	1
Autoimmune Disease [description not available]	2.5	2	0
Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	2.5	2	0
Innate Inflammatory Response [description not available]	2.78	3	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.78	3	0
Peritoneal Carcinomatosis [description not available]	3.39	7	0
Peritoneal Neoplasms Tumors or cancer of the PERITONEUM.	3.39	7	0
Breast Cancer [description not available]	7.08	1	0
Breast Neoplasms Tumors or cancer of the human BREAST.	2.08	1	0
Diseases of Immune System [description not available]	2.1	1	0
Diseases, Metabolic [description not available]	2.1	1	0
Benign Neoplasms [description not available]	2.71	3	0
Immune System Diseases Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.	2.1	1	0
Metabolic Diseases Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)	2.1	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.71	3	0
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.42	2	0
Pleural Effusion Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.	3.32	2	0
Bronchial Hyperreactivity Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.	2.13	1	0
Adenocarcinoma, Alveolar [description not available]	2.41	2	0
Adenocarcinoma, Bronchiolo-Alveolar A carcinoma derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)	2.41	2	0
Bagassosis A diffuse parenchymal lung disease caused by inhaled dust from processing SUGARCANE (bagasse), usually in the manufacturing of wallboard.	3.98	5	0
Pneumoconiosis A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.	3.98	5	0
Pleural Diseases Diseases involving the PLEURA.	5.15	18	0
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.08	1	0
Alveolitis, Fibrosing [description not available]	4.51	9	0
Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.	4.51	9	0
Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM.	2.69	3	0
Calcification, Pathologic [description not available]	3.49	8	0
Calcinosis Pathologic deposition of calcium salts in tissues.	3.49	8	0
Disease Exacerbation [description not available]	2.43	2	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.39	2	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.36	2	0
Cancer of Gastrointestinal Tract [description not available]	2.39	2	0
Experimental Neoplasms [description not available]	2.36	2	0
Cancer of Kidney [description not available]	1.96	1	0
Experimental Leukemia [description not available]	1.96	1	0
Cancer of Liver [description not available]	1.96	1	0
Cancer of the Thyroid [description not available]	1.96	1	0
Cocarcinogenesis The combination of two or more different factors in the production of cancer.	1.96	1	0
Kidney Neoplasms Tumors or cancers of the KIDNEY.	1.96	1	0
Liver Neoplasms Tumors or cancer of the LIVER.	1.96	1	0
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	1.96	1	0
Canine Diseases [description not available]	1.98	1	0
Caprine Diseases [description not available]	1.98	1	0
Abnormalities, Autosome [description not available]	2.38	2	0
Cardiac Cancer [description not available]	1.98	1	0
Synovioma [description not available]	1.98	1	0
Chromosomal Translocation [description not available]	1.98	1	0
Sarcoma, Synovial A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)	1.98	1	0
Fibromatosis [description not available]	1.99	1	0
Local Neoplasm Recurrence [description not available]	1.99	1	0
Fibroma A benign tumor of fibrous or fully developed connective tissue.	1.99	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	1.99	1	0
Respiratory Tract Neoplasms New abnormal growth of tissue in the RESPIRATORY SYSTEM.	2.38	2	0
Obstructive Lung Diseases [description not available]	2	1	0
Lung Diseases, Obstructive Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.	2	1	0
Lymphocytosis Excess of normal lymphocytes in the blood or in any effusion.	2.01	1	0
Aneuploid [description not available]	1.98	1	0
Sarcoma, Epithelioid [description not available]	1.97	1	0
Sarcoma A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.	1.97	1	0
Disease, Pulmonary [description not available]	3.07	5	0
Lung Diseases Pathological processes involving any part of the LUNG.	3.07	5	0
Granuloma, Hodgkin [description not available]	1.97	1	0
Cancer of Stomach [description not available]	1.97	1	0
Hodgkin Disease A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.	1.97	1	0
Stomach Neoplasms Tumors or cancer of the STOMACH.	1.97	1	0

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