Page last updated: 2024-10-15

tremolite

Description

tremolite: see also actinolite; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131634194
MeSH IDM0047651

Synonyms (6)

Synonym
tremolite
tremolite asbestos
asbestos, tremolite
77536-68-6
qn851s6iry ,
abkhazite

Research Excerpts

Overview

Tremolite is an amphibole which has been implicated in a variety of disease patterns in different parts of the world. It is present in some chrysotile, talc, and vermiculite deposits.

ExcerptReference
"Tremolite is a noncommercial form of amphibole mineral that is present in some chrysotile, talc, and vermiculite deposits. "( Evaluation of tremolite asbestos exposures associated with the use of commercial products.
Adams, RE; Barlow, CA; Finley, BL; Paustenbach, DJ; Phelka, AD; Pierce, JS; Thuett, KA, 2012
)
"Tremolite is an amphibole which has been implicated in a variety of disease patterns in different parts of the world. "( Biological effects of tremolite.
Berry, G; Brown, RC; Chamberlain, M; Davies, R; Griffiths, DM; Pooley, FD; Wagner, JC, 1982
)

Effects

Tremolite contamination has been proposed as the cause of mesothelioma in workers exposed to commercial chrysotile. Tremolite has been associated with an increased risk of lung cancer in a study of vermiculite miners.

ExcerptReference
"Tremolite contamination has been proposed as the cause of mesothelioma in workers exposed to commercial chrysotile. "( A case of occupational peritoneal mesothelioma from exposure to tremolite-free chrysotile in Quebec, Canada: A black swan case.
Egilman, D; Menéndez, LM, 2011
)
"Tremolite has been associated with an increased risk of lung cancer in a study of vermiculite miners; the slope of the exposure-response relationship was similar to that for crocidolite miners and much higher than that of chrysotile miners."( Human evidence: lung cancer mortality risk from chrysotile exposure.
Hughes, JM, 1994
)

Treatment

ExcerptReference
"Rats treated with tremolite developed very high levels of pulmonary fibrosis as well as 16 carcinomas and two mesotheliomas in a group of 39 animals."( Inhalation studies on the effects of tremolite and brucite dust in rats.
Addison, J; Bolton, RE; Davis, JM; Donaldson, K; Jones, AD; Miller, BG, 1985
)

Toxicity

ExcerptReference
" Despite weathered fibers appearing less toxic than "stored/laboratory" ones, NOA is to be considered far from safe because of fibrous nature and residual surface reactivity."( The effect of weathering on ecopersistence, reactivity, and potential toxicity of naturally occurring asbestos and asbestiform minerals.
Compagnoni, R; Enrico Favero-Longo, S; Fubini, B; Piervittori, R; Tomatis, M; Turci, F, 2009
)
"Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals."( Long-term toxicity of naturally occurring asbestos in male Fischer 344 rats.
Cyphert, JM; Gavett, SH; Kodavanti, UP; McGee, MA; Nyska, A; Schladweiler, MC, 2016
)

Dosage Studied

ExcerptReference
" The ambient dosage of asbestos has confirmed the existence of environmental pollution by chrysotile fibres and above all by tremolite."( [Environmental mesotheliomas in northeast Corsica].
Billon-Galland, MA; Boutin, C; De Vuyst, P; Dumortier, P; Farisse, P; Hereng, P; Rey, F; Viallat, JR, 1993
)
" Our study reveals the critical nature of EMP morphometric parameters for exposure assessment and dosing approaches used in toxicity studies."( Differential responses of murine alveolar macrophages to elongate mineral particles of asbestiform and non-asbestiform varieties: Cytotoxicity, cytokine secretion and transcriptional changes.
Guppi, S; Khaliullin, TO; Kisin, ER; Shvedova, AA; Yanamala, N; Zhernovkov, V, 2020
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (192)

TimeframeStudies, This Drug (%)All Drugs %
pre-199037 (19.27)18.7374
1990's47 (24.48)18.2507
2000's47 (24.48)29.6817
2010's46 (23.96)24.3611
2020's15 (7.81)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.49%)5.53%
Reviews14 (6.90%)6.00%
Case Studies15 (7.39%)4.05%
Observational1 (0.49%)0.25%
Other172 (84.73%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]