Prostaglandin F2-alpha receptor

A prostaglandin F2-alpha receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43088]

Synonyms

PGF receptor;
PGF2-alpha receptor;
Prostanoid FP receptor

Research

Bioassay Publications (16)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (6.25)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (68.75)	29.6817
2010's	4 (25.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (11)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dinoprost	Homo sapiens (human)	IC50	0.0139	4	4
dinoprost	Homo sapiens (human)	Ki	0.1190	1	1
cloprostenol	Homo sapiens (human)	IC50	0.0015	2	2
cloprostenol	Homo sapiens (human)	Ki	0.0310	1	1
16,16-dimethylprostaglandin f2alpha	Homo sapiens (human)	IC50	0.0160	1	1
mk-0524	Homo sapiens (human)	Ki	9.9910	1	1
cj-023,423	Homo sapiens (human)	Ki	5.0000	1	1
l-798106	Homo sapiens (human)	Ki	0.5000	1	1
fevipiprant	Homo sapiens (human)	IC50	10.0000	1	1
fr181157	Homo sapiens (human)	Ki	1.0000	3	3
cay 10580	Homo sapiens (human)	Ki	13.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dinoprostone	Homo sapiens (human)	EC50	0.2500	1	1
dinoprost	Homo sapiens (human)	EC50	0.0518	2	2
cloprostenol	Homo sapiens (human)	EC50	0.0100	1	1
fluprostenol	Homo sapiens (human)	EC50	0.0036	1	1
16,16-dimethylprostaglandin f2alpha	Homo sapiens (human)	EC50	0.0900	1	1

Enables

This protein enables 1 target(s):

Target	Category	Definition
prostaglandin F receptor activity	molecular function	Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. [ISBN:0198506732]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
parturition	biological process	The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. [ISBN:0198506732]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
response to estradiol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]
response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
cellular response to prostaglandin D stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. [GOC:sl]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]

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