A multidrug and toxin extrusion protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96FL8]
MATE-1;
hMATE-1;
Solute carrier family 47 member 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| niacin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| tacrine | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| amantadine | Homo sapiens (human) | IC50 | 37.8000 | 1 | 1 |
| astemizole | Homo sapiens (human) | IC50 | 26.4000 | 1 | 1 |
| bithionol | Homo sapiens (human) | IC50 | 5.2000 | 1 | 1 |
| buspirone | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| camostat | Homo sapiens (human) | IC50 | 2.9000 | 1 | 1 |
| carvedilol | Homo sapiens (human) | IC50 | 92.4000 | 1 | 1 |
| cetirizine | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| ciclopirox | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| cimetidine | Homo sapiens (human) | IC50 | 3.0333 | 3 | 3 |
| clonidine | Homo sapiens (human) | IC50 | 33.3000 | 1 | 1 |
| diclofenac | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| dipyridamole | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| disopyramide | Homo sapiens (human) | IC50 | 66.0000 | 1 | 1 |
| domperidone | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| epinastine | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| furosemide | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| gabexate | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| granisetron | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| lidocaine | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| imipramine | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| indomethacin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| avapro | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| losartan | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| metformin | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| mitoxantrone | Homo sapiens (human) | IC50 | 0.3733 | 3 | 3 |
| nifekalant | Homo sapiens (human) | IC50 | 2.7500 | 3 | 3 |
| ondansetron | Homo sapiens (human) | IC50 | 0.0875 | 4 | 4 |
| orphenadrine | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| pantoprazole | Homo sapiens (human) | IC50 | 16.2667 | 3 | 3 |
| pentamidine | Homo sapiens (human) | IC50 | 1.7033 | 3 | 3 |
| phenacetin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| prazosin | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| ranitidine | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| rimantadine | Homo sapiens (human) | IC50 | 7.3000 | 1 | 1 |
| risperidone | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| imatinib | Homo sapiens (human) | IC50 | 0.1467 | 3 | 3 |
| sulfacetamide | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| sumatriptan | Homo sapiens (human) | IC50 | 6.7000 | 1 | 1 |
| thiabendazole | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| ici 204,219 | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| spironolactone | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| ethinyl estradiol | Homo sapiens (human) | IC50 | 21.1000 | 1 | 1 |
| tubocurarine | Homo sapiens (human) | IC50 | 9.4000 | 1 | 1 |
| methylergonovine | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| azacitidine | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| dihydroergotamine | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| erythromycin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| pimozide | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| vecuronium bromide | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| topotecan | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| aripiprazole | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| irinotecan | Homo sapiens (human) | IC50 | 4.7667 | 3 | 3 |
| telmisartan | Homo sapiens (human) | IC50 | 17.9000 | 1 | 1 |
| levofloxacin | Homo sapiens (human) | IC50 | 17.9000 | 1 | 1 |
| dabigatran | Homo sapiens (human) | IC50 | 8.1000 | 1 | 1 |
| cortisone | Homo sapiens (human) | IC50 | 21.4000 | 1 | 1 |
| noscapine | Homo sapiens (human) | IC50 | 34.5000 | 1 | 1 |
| ritonavir | Homo sapiens (human) | IC50 | 2.1933 | 3 | 3 |
| quinidine | Homo sapiens (human) | IC50 | 11.2000 | 1 | 1 |
| maraviroc | Homo sapiens (human) | IC50 | 17.3000 | 1 | 1 |
| indinavir sulfate | Homo sapiens (human) | IC50 | 3.8000 | 3 | 3 |
| enalapril | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| famotidine | Homo sapiens (human) | IC50 | 0.7600 | 1 | 1 |
| chlorhexidine | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| organic cation transmembrane transporter activity | molecular function | Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| L-amino acid transmembrane transporter activity | molecular function | Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] |
| thiamine transmembrane transporter activity | molecular function | Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| antiporter activity | molecular function | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] |
| putrescine transmembrane transporter activity | molecular function | Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. [GOC:ai] |
| transmembrane transporter activity | molecular function | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729] |
| xenobiotic transmembrane transporter activity | molecular function | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
| L-arginine transmembrane transporter activity | molecular function | Enables the transfer of L-arginine from one side of a membrane to the other. [GOC:dph, RHEA:32143] |
| polyspecific organic cation:proton antiporter activity | molecular function | Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics. [PMID:17047166, PMID:17509534] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| xenobiotic transmembrane transport | biological process | The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:ai, GOC:bf, GOC:krc] |
| organic cation transport | biological process | The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. [GOC:ai] |
| putrescine transport | biological process | The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. [GOC:krc, ISBN:0198506732] |
| xenobiotic transport | biological process | The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| thiamine transmembrane transport | biological process | The process in which thiamine is transported across a membrane. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:mah] |
| amino acid import across plasma membrane | biological process | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186] |
| L-arginine import across plasma membrane | biological process | The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol. [GOC:krc, PMID:8195186] |
| L-alpha-amino acid transmembrane transport | biological process | The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore. [GOC:kmv, GOC:TermGenie, PMID:14668347] |
| proton transmembrane transport | biological process | The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie] |
| L-arginine transmembrane transport | biological process | The directed movement of L-arginine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:18357653, PMID:22822152, PMID:8195186] |
| xenobiotic detoxification by transmembrane export across the plasma membrane | biological process | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. [PMID:28355133] |