A voltage-dependent calcium channel subunit alpha-2/delta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3S7]
Voltage-gated calcium channel subunit alpha-2/delta-4
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tacrine | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| nimodipine | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| ith 4012 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated calcium channel complex | cellular component | A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| detection of light stimulus involved in visual perception | biological process | The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |