Proteins > Muscarinic acetylcholine receptor M5
Page last updated: 2024-08-07 15:48:27
Muscarinic acetylcholine receptor M5
A muscarinic acetylcholine receptor M5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08912]
Synonyms
Research
Bioassay Publications (89)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 7 (7.87) | 18.7374 |
| 1990's | 12 (13.48) | 18.2507 |
| 2000's | 31 (34.83) | 29.6817 |
| 2010's | 37 (41.57) | 24.3611 |
| 2020's | 2 (2.25) | 2.80 |
Compounds (143)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nifedipine | Homo sapiens (human) | ID50 | 700,000.0050 | 2 | 2 |
| carbachol | Homo sapiens (human) | ED50 | 2.0500 | 2 | 2 |
| 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester | Homo sapiens (human) | ID50 | 4,000,000.0000 | 1 | 1 |
| 1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester | Homo sapiens (human) | ID50 | 3,200,000.0000 | 1 | 1 |
| atropine | Homo sapiens (human) | ED50 | 0.0001 | 2 | 2 |
| atropine | Homo sapiens (human) | ID50 | 0.0001 | 1 | 1 |
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.Journal of medicinal chemistry, , Jan-01, Volume: 41, Issue:1, 1998
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.Journal of medicinal chemistry, , Nov-22, Volume: 44, Issue:24, 2001
Synthesis and calcium channel antagonist activity of dialkyl 4- (dihydropyridinyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylates.Journal of medicinal chemistry, , Volume: 30, Issue:4, 1987
Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pyridinyl)-3,5-pyridinedicarboxylates.Journal of medicinal chemistry, , Volume: 29, Issue:12, 1986
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.Journal of medicinal chemistry, , Jan-01, Volume: 41, Issue:1, 1998
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
Beta-lactam analogues of oxotremorine. 3- and 4-methyl-substituted 2-azetidinones.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.Bioorganic & medicinal chemistry, , Dec-15, Volume: 15, Issue:24, 2007
Identification and characterization of m1 selective muscarinic receptor antagonists1.Journal of medicinal chemistry, , Feb-11, Volume: 42, Issue:3, 1999
3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships.Journal of medicinal chemistry, , Feb-03, Volume: 38, Issue:3, 1995
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.Bioorganic & medicinal chemistry, , Dec-15, Volume: 17, Issue:24, 2009
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.Journal of medicinal chemistry, , Jul-10, Volume: 51, Issue:13, 2008
Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists.Bioorganic & medicinal chemistry, , Jan-15, Volume: 15, Issue:2, 2007
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the bindJournal of medicinal chemistry, , Dec-14, Volume: 49, Issue:25, 2006
C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists.Journal of medicinal chemistry, , Dec-20, Volume: 44, Issue:26, 2001
Identification and characterization of m4 selective muscarinic antagonists.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998
Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.Journal of medicinal chemistry, , Jun-09, Volume: 38, Issue:12, 1995
Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.Bioorganic & medicinal chemistry, , Dec-15, Volume: 17, Issue:24, 2009
Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Nov-07, Volume: 40, Issue:23, 1997
3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships.Journal of medicinal chemistry, , Feb-03, Volume: 38, Issue:3, 1995
Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 25, Issue:19, 2015
Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1).Journal of medicinal chemistry, , Nov-13, Volume: 57, Issue:21, 2014
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the bindJournal of medicinal chemistry, , Dec-14, Volume: 49, Issue:25, 2006
Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders.Journal of medicinal chemistry, , Sep-25, Volume: 46, Issue:20, 2003
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
1,4-dioxane, a suitable scaffold for the development of novel M₃ muscarinic receptor antagonists.Journal of medicinal chemistry, , Feb-23, Volume: 55, Issue:4, 2012
Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.Journal of medicinal chemistry, , Mar-22, Volume: 50, Issue:6, 2007
Identification and characterization of m4 selective muscarinic antagonists.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.Journal of medicinal chemistry, , Jul-22, Volume: 37, Issue:15, 1994
[no title available]Journal of medicinal chemistry, , 06-13, Volume: 62, Issue:11, 2019
Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands.Bioorganic & medicinal chemistry letters, , May-07, Volume: 11, Issue:9, 2001
Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 23, Issue:13, 2013
Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human MBioorganic & medicinal chemistry letters, , 02-01, Volume: 29, Issue:3, 2019
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).Journal of medicinal chemistry, , Sep-25, Volume: 57, Issue:18, 2014
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.Journal of medicinal chemistry, , Jun-11, Volume: 52, Issue:11, 2009
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships.Journal of medicinal chemistry, , Nov-07, Volume: 40, Issue:23, 1997
Synthesis and antimuscarinic activity of some 1-cycloalkyl-1-hydroxy-1-phenyl-3-(4-substituted piperazinyl)-2-propanones and related compounds.Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
Enantioselectivity of muscarinic antagonists. 2,2-Dicyclohexyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides and related 3-oxides.Journal of medicinal chemistry, , Volume: 31, Issue:9, 1988
Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M-2 muscarinic receptors.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
[no title available],
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHBioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.Bioorganic & medicinal chemistry, , May-15, Volume: 21, Issue:10, 2013
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.European journal of medicinal chemistry, , Volume: 63, 2013
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.Journal of medicinal chemistry, , Nov-27, Volume: 51, Issue:22, 2008
Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands.Bioorganic & medicinal chemistry letters, , May-07, Volume: 11, Issue:9, 2001
Identification and characterization of m4 selective muscarinic antagonists.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010
Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Discovery of ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
The discovery of new spirocyclic muscarinic M3 antagonists.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Discovery of ML326: The first sub-micromolar, selective M5 PAM.Bioorganic & medicinal chemistry letters, , May-15, Volume: 23, Issue:10, 2013
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.Journal of medicinal chemistry, , Feb-23, Volume: 55, Issue:4, 2012
Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 20, Issue:2, 2010
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.Journal of medicinal chemistry, , Jun-11, Volume: 52, Issue:11, 2009
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| phosphatidylinositol phospholipase C activity | molecular function | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+. [EC:3.1.4.11, RHEA:33179] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| G protein-coupled acetylcholine receptor activity | molecular function | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:fj, GOC:mah] |
| G protein-coupled serotonin receptor activity | molecular function | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| postsynaptic membrane | cellular component | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732] |
Active In
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
Involved In
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|
| gastric acid secretion | biological process | The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. [GOC:hjd] |
| G protein-coupled acetylcholine receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription. [GOC:mah, ISBN:0815316194] |
| dopamine transport | biological process | The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:ai] |
| transmission of nerve impulse | biological process | The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. [GOC:curators, ISBN:0815316194] |
| regulation of phosphatidylinositol dephosphorylation | biological process | Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol. [GOC:dph, GOC:tb] |
| G protein-coupled serotonin receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands. [GOC:mah] |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | biological process | An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] |