An excitatory amino acid transporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43004]
| Target | Category | Definition |
|---|
| L-glutamate transmembrane transporter activity | molecular function | Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| high-affinity L-glutamate transmembrane transporter activity | molecular function | Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:2.A.3.10.5] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| monoatomic anion transmembrane transporter activity | molecular function | Enables the transfer of a negatively charged ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] |
| glutamate:sodium symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). [TC:2.A.27.1.1] |
| cysteine transmembrane transporter activity | molecular function | Enables the transfer of cysteine from one side of a membrane to the other. [GOC:mah] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| neutral L-amino acid transmembrane transporter activity | molecular function | Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| axolemma | cellular component | The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653] |
| vesicle | cellular component | Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles] |
| cell body | cellular component | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. [GOC:go_curators] |
| neuron projection terminus | cellular component | The specialized, terminal region of a neuron projection such as an axon or a dendrite. [GOC:jl] |
| membrane raft | cellular component | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567] |
| astrocyte projection | cellular component | A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. [NIF_Subcellular:sao1630537580] |
| glutamatergic synapse | cellular component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
| Target | Category | Definition |
|---|
| glutathione biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] |
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| neurotransmitter transport | biological process | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| visual behavior | biological process | The behavior of an organism in response to a visual stimulus. [GOC:jid, GOC:pr] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| response to wounding | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. [GOC:go_curators] |
| L-glutamate transmembrane transport | biological process | The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. [PMID:21307582] |
| telencephalon development | biological process | The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] |
| adult behavior | biological process | Behavior in a fully developed and mature organism. [GOC:mah, ISBN:0877797099] |
| multicellular organism growth | biological process | The increase in size or mass of an entire multicellular organism, as opposed to cell growth. [GOC:bf, GOC:curators, GOC:dph, GOC:tb] |
| response to amino acid | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:ef, GOC:mlg] |
| positive regulation of glucose import | biological process | Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai, GOC:dph, GOC:tb] |
| protein homotrimerization | biological process | The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. [GOC:hjd] |
| transepithelial transport | biological process | The directed movement of a substance from one side of an epithelium to the other. [GOC:mah, GOC:yaf, ISBN:0716731363] |
| L-aspartate transmembrane transport | biological process | The directed movement of L-aspartate across a membrane by means of some agent such as a transporter or a pore. [PMID:21307582] |
| D-aspartate import across plasma membrane | biological process | The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. [PMID:7914198] |
| cellular response to cocaine | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:mah] |
| monoatomic anion transmembrane transport | biological process | The process in which a monoatomic anion is transported across a membrane. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. [GOC:dos, GOC:vw] |
| L-glutamate import across plasma membrane | biological process | The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos] |
| neurotransmitter reuptake | biological process | The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol. [GOC:dos] |
| L-aspartate import across plasma membrane | biological process | The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000069, PMID:7914198] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |
| cysteine transmembrane transport | biological process | The directed movement of cysteine across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:17435223] |