Sodium/potassium-transporting ATPase subunit gamma

A sodium/potassium-transporting ATPase subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54710]

Synonyms

Na(+)/K(+) ATPase subunit gamma;
FXYD domain-containing ion transport regulator 2;
Sodium pump gamma chain

Research

Bioassay Publications (11)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (9.09)	18.7374
1990's	3 (27.27)	18.2507
2000's	3 (27.27)	29.6817
2010's	4 (36.36)	24.3611
2020's	0 (0.00)	2.80

Compounds (12)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lansoprazole	Homo sapiens (human)	IC50	39.8107	1	1
omeprazole	Homo sapiens (human)	IC50	31.6228	1	1
pantoprazole	Homo sapiens (human)	IC50	199.5260	1	1
rostafuroxin	Homo sapiens (human)	IC50	1.5000	1	1
ouabain	Homo sapiens (human)	IC50	6.0000	1	1
digitoxin	Homo sapiens (human)	IC50	0.0080	1	1
digoxin	Homo sapiens (human)	IC50	0.3350	2	2
digitoxigenin	Homo sapiens (human)	IC50	0.1673	5	6
phakellistatin 2	Homo sapiens (human)	IC50	100.0000	1	1
digitoxigenin monodigitoxoside	Homo sapiens (human)	IC50	0.0070	1	1
evomonoside	Homo sapiens (human)	IC50	0.0058	1	2
halisulfate 1	Homo sapiens (human)	IC50	3.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ouabain	Homo sapiens (human)	LC50	9.4000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
ATPase activator activity	molecular function	Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp]
protein-macromolecule adaptor activity	molecular function	The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]
sodium channel regulator activity	molecular function	Binds to and modulates the activity of a sodium channel. [GOC:mah]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
sodium:potassium-exchanging ATPase complex	cellular component	Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
intracellular sodium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah]
establishment or maintenance of transmembrane electrochemical gradient	biological process	The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. [GOC:mah, GOC:sm]
intracellular potassium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah]
sodium ion export across plasma membrane	biological process	The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689]
transmembrane transport	biological process	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
proton transmembrane transport	biological process	The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
positive regulation of P-type sodium:potassium-exchanging transporter activity	biological process	Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
potassium ion import across plasma membrane	biological process	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]
regulation of sodium ion transmembrane transporter activity	biological process	Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]

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