Proteins > Sodium/potassium-transporting ATPase subunit gamma
Page last updated: 2024-08-07 18:38:23

Sodium/potassium-transporting ATPase subunit gamma

A sodium/potassium-transporting ATPase subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54710]

Synonyms

Na(+)/K(+) ATPase subunit gamma;
FXYD domain-containing ion transport regulator 2;
Sodium pump gamma chain

Research

Bioassay Publications (11)

TimeframeStudies on this Protein(%)All Drugs %
pre-19901 (9.09)18.7374
1990's3 (27.27)18.2507
2000's3 (27.27)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Compounds (12)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
lansoprazoleHomo sapiens (human)IC5039.810711
omeprazoleHomo sapiens (human)IC5031.622811
pantoprazoleHomo sapiens (human)IC50199.526011
rostafuroxinHomo sapiens (human)IC501.500011
ouabainHomo sapiens (human)IC506.000011
digitoxinHomo sapiens (human)IC500.008011
digoxinHomo sapiens (human)IC500.335022
digitoxigeninHomo sapiens (human)IC500.167356
phakellistatin 2Homo sapiens (human)IC50100.000011
digitoxigenin monodigitoxosideHomo sapiens (human)IC500.007011
evomonosideHomo sapiens (human)IC500.005812
halisulfate 1Homo sapiens (human)IC503.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ouabainHomo sapiens (human)LC509.400011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
ATPase activator activitymolecular functionBinds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp]
protein-macromolecule adaptor activitymolecular functionThe binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]
sodium channel regulator activitymolecular functionBinds to and modulates the activity of a sodium channel. [GOC:mah]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
sodium:potassium-exchanging ATPase complexcellular componentSodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732]

Involved In

This protein is involved in 9 target(s):

TargetCategoryDefinition
intracellular sodium ion homeostasisbiological processA homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah]
establishment or maintenance of transmembrane electrochemical gradientbiological processThe directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. [GOC:mah, GOC:sm]
intracellular potassium ion homeostasisbiological processA homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah]
sodium ion export across plasma membranebiological processThe directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689]
transmembrane transportbiological processThe process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
proton transmembrane transportbiological processThe directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
positive regulation of P-type sodium:potassium-exchanging transporter activitybiological processAny process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity. [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880]
potassium ion import across plasma membranebiological processThe directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]
regulation of sodium ion transmembrane transporter activitybiological processAny process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]