P2X purinoceptor 3

A P2X purinoceptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56373]

Synonyms

P2X3;
ATP receptor;
Purinergic receptor

Research

Bioassay Publications (12)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (41.67)	29.6817
2010's	3 (25.00)	24.3611
2020's	4 (33.33)	2.80

Compounds (23)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid	Homo sapiens (human)	IC50	0.2400	1	1
ormetoprim	Homo sapiens (human)	IC50	10.0000	1	1
8-azidoadenosine 5'-triphosphate	Homo sapiens (human)	IC50	100.0000	2	2
6-thioinosine-5'-triphosphate	Homo sapiens (human)	IC50	0.7609	2	2
spinorphin	Homo sapiens (human)	IC50	0.0000	2	2
mrs 2219	Homo sapiens (human)	IC50	58.3000	1	1
imd 0354	Homo sapiens (human)	IC50	10.0000	1	1
nf023	Homo sapiens (human)	IC50	28.5000	1	1
bafilomycin a1	Homo sapiens (human)	IC50	0.7550	1	1
a-317491	Homo sapiens (human)	IC50	0.1110	4	4
a-317491	Homo sapiens (human)	Ki	0.0090	1	1
af 353	Homo sapiens (human)	IC50	0.0411	3	4
af 353	Homo sapiens (human)	Ki	0.0417	1	0
a 803467	Homo sapiens (human)	IC50	10.0000	1	1
archazolid a	Homo sapiens (human)	IC50	0.0861	1	1
archazolid b	Homo sapiens (human)	IC50	0.3530	1	1
af-219	Homo sapiens (human)	IC50	0.0450	2	2
af-219	Homo sapiens (human)	Ki	0.0891	1	0

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid	Homo sapiens (human)	EC50	0.9700	2	2
suramin	Homo sapiens (human)	EC50	8.9500	2	2
adenosine diphosphate	Homo sapiens (human)	EC50	100.0000	1	1
diadenosine tetraphosphate	Homo sapiens (human)	EC50	0.5000	1	1
5'-adenylyl (beta,gamma-methylene)diphosphonate	Homo sapiens (human)	EC50	9.2000	1	1
alpha,beta-methyleneadenosine 5'-triphosphate	Homo sapiens (human)	EC50	0.7400	1	1
adenosine 5'-o-(3-thiotriphosphate)	Homo sapiens (human)	EC50	0.6900	1	1
2-methylthio-atp	Homo sapiens (human)	EC50	0.3500	1	1
adp beta s	Homo sapiens (human)	EC50	8.8000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
purinergic nucleotide receptor activity	molecular function	Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]
extracellularly ATP-gated monoatomic cation channel activity	molecular function	Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:bf, GOC:mah, PMID:9755289]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
axon	cellular component	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
Schaffer collateral - CA1 synapse	cellular component	A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689]
hippocampal mossy fiber to CA3 synapse	cellular component	One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762]
postsynapse	cellular component	The part of a synapse that is part of the post-synaptic cell. [GOC:dos]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 21 target(s):

Target	Category	Definition
response to hypoxia	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
neuromuscular synaptic transmission	biological process	The process of synaptic transmission from a neuron to a muscle, across a synapse. [GOC:dos, GOC:jl, MeSH:D009435]
response to heat	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:lr]
response to cold	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:lr]
response to mechanical stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:hb]
response to carbohydrate	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. [GOC:jl]
positive regulation of calcium ion transport into cytosol	biological process	Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. [GOC:dph, GOC:tb]
urinary bladder smooth muscle contraction	biological process	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract. [GOC:mr, GOC:mtg_muscle, PMID:11768524, PMID:18276178, PMID:538956]
peristalsis	biological process	A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. [ISBN:0198506732]
purinergic nucleotide receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, PMID:9755289]
regulation of synaptic plasticity	biological process	A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]
behavioral response to pain	biological process	Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid]
positive regulation of calcium-mediated signaling	biological process	Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. [GOC:ai]
sensory perception of taste	biological process	The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. [GOC:ai]
establishment of localization in cell	biological process	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
excitatory postsynaptic potential	biological process	A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
protein homotrimerization	biological process	The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. [GOC:hjd]
cellular response to ATP	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah]
inorganic cation transmembrane transport	biological process	A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]