Protein-arginine deiminase type-4

A protein-arginine deiminase type-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UM07]

Synonyms

EC 3.5.3.15;
HL-60 PAD;
Peptidylarginine deiminase IV;
Protein-arginine deiminase type IV

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (19)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
azathioprine	Homo sapiens (human)	IC50	8,100.0000	1	1
leflunomide	Homo sapiens (human)	IC50	2,400.0000	1	1
mesalamine	Homo sapiens (human)	IC50	10,000.0000	1	1
streptonigrin	Homo sapiens (human)	IC50	2.5000	1	1
sulfamethoxazole	Homo sapiens (human)	IC50	10,000.0000	1	1
sulfapyridine	Homo sapiens (human)	IC50	10,000.0000	1	1
trimethoprim	Homo sapiens (human)	IC50	7,500.0000	1	1
streptomycin	Homo sapiens (human)	IC50	1,800.0000	1	1
streptomycin	Homo sapiens (human)	Ki	560.0000	1	1
methotrexate	Homo sapiens (human)	IC50	10,000.0000	1	1
clindamycin	Homo sapiens (human)	IC50	5,100.0000	1	1
zithromax	Homo sapiens (human)	IC50	10,000.0000	1	1
n-alpha-benzoyl-n5-(2-chloro-1-iminoethyl)-l-ornithine amide	Homo sapiens (human)	IC50	5.9000	1	1
tetracycline	Homo sapiens (human)	IC50	780.0000	1	1
chlortetracycline	Homo sapiens (human)	IC50	100.0000	1	1
chlortetracycline	Homo sapiens (human)	Ki	325.0000	2	2
minocycline	Homo sapiens (human)	IC50	620.0000	1	1
minocycline	Homo sapiens (human)	Ki	360.0000	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-benzoyl-l-arginine	Homo sapiens (human)	Km	410.0000	1	1
benzoylarginine ethyl ester	Homo sapiens (human)	Km	1,360.0000	1	1
benzoyl l-arginine methyl ester	Homo sapiens (human)	Km	1,660.0000	1	1
n(alpha)-benzoylarginineamide	Homo sapiens (human)	Km	250.0000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
protein-arginine deiminase activity	molecular function	Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent. [PMID:27393304]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
histone arginine deiminase activity	molecular function	Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination. [PMID:15339660]
histone H3R2 arginine deiminase activity	molecular function	Catalysis of the reaction: H2O + histone H3 L-arginyl (position 2)= histone H3 L-citrullyl (position 2) + NH4+, resulting in histone H3 citrullination at position 2. [PMID:15339660]
histone H3R8 arginine deiminase activity	molecular function	Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8. [PMID:15339660]
histone H3R17 arginine deiminase activity	molecular function	Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17. [PMID:15339660]
histone H3R26 arginine deiminase activity	molecular function	Catalysis of the reaction: H2O + histone H3 L-arginyl (position 26)= histone H3 L-citrullyl (position 26) + NH4+, resulting in histone H3 citrullination at position 26. [PMID:15339660]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
chromatin organization	biological process	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130]
nucleosome assembly	biological process	The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. [GOC:mah]
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
stem cell population maintenance	biological process	The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types. [GOC:mah, ISBN:0878932437]
protein modification process	biological process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl]
post-translational protein modification	biological process	The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. [GOC:jsg]
innate immune response	biological process	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]