Programmed cell death 1 ligand 1

A programmed cell death 1 ligand 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NZQ7]

Synonyms

PD-L1;
PDCD1 ligand 1;
Programmed death ligand 1;
hPD-L1;
B7 homolog 1;
B7-H1

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	3 (100.00)	2.80

Compounds (4)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sesamin	Homo sapiens (human)	IC50	100.0000	1	1
pomalidomide	Homo sapiens (human)	IC50	0.0100	1	1
apiin	Homo sapiens (human)	IC50	100.0000	1	1
fosbretabulin	Homo sapiens (human)	IC50	100.0000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
transcription coactivator activity	molecular function	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
receptor ligand activity	molecular function	The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands). [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
actin cytoskeleton	cellular component	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]
early endosome membrane	cellular component	The lipid bilayer surrounding an early endosome. [GOC:pz]
recycling endosome membrane	cellular component	The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]

Involved In

This protein is involved in 21 target(s):

Target	Category	Definition
adaptive immune response	biological process	An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
negative regulation of T cell mediated immune response to tumor cell	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell. [GOC:add]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
T cell costimulation	biological process	The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. [ISBN:0781735149]
negative regulation of type II interferon production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
negative regulation of interleukin-10 production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
positive regulation of interleukin-10 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
response to cytokine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:sl]
TRIF-dependent toll-like receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GOC:BHF, PMID:12855817]
positive regulation of T cell proliferation	biological process	Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
negative regulation of activated T cell proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation. [GOC:go_curators]
negative regulation of tumor necrosis factor superfamily cytokine production	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24187568]
negative regulation of CD4-positive, alpha-beta T cell proliferation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol]
negative regulation of CD8-positive, alpha-beta T cell activation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol]
cellular response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
negative regulation of T cell proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of T cell proliferation. [GOC:jl]