bupivacaine has been researched along with Necrosis in 47 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "LLLT, at the dose used, reduced fibrosis and myonecrosis in the sternomastoid muscle triggered by bupivacaine, accelerating the muscle regeneration process." | 7.85 | Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine. ( Alessi Pissulin, CN; Henrique Fernandes, AA; Michelin Matheus, SM; Rossi E Silva, RC; Sanchez Orellana, AM, 2017) |
| "We induced acute skeletal muscle necrosis in rats using bupivacaine hydrochloride and found that both 2,5- and 2,3-dihydroxybenzoic acid significantly increased in skeletal muscle." | 7.71 | Bupivacaine hydrochloride induces muscle fiber necrosis and hydroxyl radical formation-dimethyl sulphoxide reduces hydroxyl radical formation. ( Iguchi, H; Kinoshita, M; Nomoto, N; Sugimoto, H; Wakata, N, 2001) |
| "To determine how and when the satellite cells are stimulated to replicate in muscle regeneration, the rat soleus muscle was examined chronologically after bupivacaine-induced myonecrosis." | 7.69 | Initiation of satellite cell replication in bupivacaine-induced myonecrosis. ( Nonaka, I; Saito, Y, 1994) |
| "We compared the morphologic characteristics of muscle fiber necrosis and subsequent regeneration after injury induced by intramuscular injections of bupivacaine hydrochloride (BPVC) and a variety of solutions at acid and alkaline pH (acetic anhydride, citric acid buffer, and sodium carbonate buffer)." | 7.68 | Comparison of behavior in muscle fiber regeneration after bupivacaine hydrochloride- and acid anhydride-induced myonecrosis. ( Akiyama, C; Kobayashi, S; Nonaka, I, 1992) |
| "Immunohistochemical analysis of the inflammatory cells and complement C3 in the rat skeletal muscle was performed chronologically in bupivacaine-induced myonecrosis." | 7.68 | Analysis of inflammatory cells and complement C3 in bupivacaine-induced myonecrosis. ( Arahata, K; Hiyamuta, E; Orimo, S; Sugita, H, 1991) |
| "5% bupivacaine hydrochloride (BPVC) (Marcaine), into rat soleus and extensor digitorum longus (EDL) muscles produced massive fiber necrosis with extensive phagocytosis followed by rapid regeneration, predominantly in the soleus." | 7.66 | Pathophysiology of muscle fiber necrosis induced by bupivacaine hydrochloride (Marcaine). ( Ishiura, S; Nakase, H; Nonaka, I; Sugita, H; Takagi, A, 1983) |
| "LLLT, at the dose used, reduced fibrosis and myonecrosis in the sternomastoid muscle triggered by bupivacaine, accelerating the muscle regeneration process." | 3.85 | Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine. ( Alessi Pissulin, CN; Henrique Fernandes, AA; Michelin Matheus, SM; Rossi E Silva, RC; Sanchez Orellana, AM, 2017) |
| " Bupivacaine treatment in the presence of 45°C and 50°C temperatures significantly increased necrosis of bovine articular chondrocytes in this in vitro study." | 3.78 | Supraphysiologic temperature enhances cytotoxic effects of bupivacaine on bovine articular chondrocytes in an in vitro study. ( Ge, D; Liu, S; Lucas, J; Mead, RN; Ryu, J; Savoie, FH; You, Z, 2012) |
| "75% bupivacaine-injected extraocular muscles showed extensive myonecrosis and degeneration with early-stage regenerating muscle fibers." | 3.76 | Concentration-dependent bupivacaine myotoxicity in rabbit extraocular muscle. ( Guyton, DL; Phamonvaechavan, P; Poon, DY; Rajan, A; Topcu-Yilmaz, P; Zhang, C, 2010) |
| "5% bupivacaine caused minimal chondrocyte necrosis when used in pain pumps for a maximum of 48 hours." | 3.74 | The effect of local anesthetics administered via pain pump on chondrocyte viability. ( Dragoo, JL; Kanwar, R; Korotkova, T; Wood, B, 2008) |
| "In a period of 4 wk after peripheral nerve block, both long-acting local anesthetics, bupivacaine and ropivacaine, produced calcific myonecrosis suggestive of irreversible skeletal muscle damage." | 3.73 | The long term myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blocks. ( Bohl, JRE; Graf, BM; Hacke, N; Martin, E; Sinner, B; Zink, W, 2005) |
| "The aim of the study was to observe the effect of coenzyme Q10 and vitamin E supplementation on the course of the regeneration process of the longissimus lumborum muscle after bupivacaine-induced myonecrosis as well as to determine the correlation between the level of those substances in plasma and their levels in damaged and non-damaged muscular tissue in pigs." | 3.72 | The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs. ( Babińska, I; Karpińska, J; Kasperowicz, B; Mikołajczyk, A; Otrocka-Domagała, I; Purzyńska-Pugacewicz, A; Rotkiewicz, T, 2004) |
| "We induced acute skeletal muscle necrosis in rats using bupivacaine hydrochloride and found that both 2,5- and 2,3-dihydroxybenzoic acid significantly increased in skeletal muscle." | 3.71 | Bupivacaine hydrochloride induces muscle fiber necrosis and hydroxyl radical formation-dimethyl sulphoxide reduces hydroxyl radical formation. ( Iguchi, H; Kinoshita, M; Nomoto, N; Sugimoto, H; Wakata, N, 2001) |
| "To determine how and when the satellite cells are stimulated to replicate in muscle regeneration, the rat soleus muscle was examined chronologically after bupivacaine-induced myonecrosis." | 3.69 | Initiation of satellite cell replication in bupivacaine-induced myonecrosis. ( Nonaka, I; Saito, Y, 1994) |
| "We investigated the onset and duration of DNA synthesis and differentiation of muscle precursor cells in the early stage in muscle regeneration after bupivacaine induced muscle necrosis using monoclonal anti-PCA and anti-desmin antibodies." | 3.68 | Immunohistochemical analysis of myoblast proliferation and differentiation in experimental skeletal muscle regeneration. ( Abe, J; Hizawa, K; Ii, K; Kagawa, N; Ono, K, 1993) |
| "Immunohistochemical analysis of the inflammatory cells and complement C3 in the rat skeletal muscle was performed chronologically in bupivacaine-induced myonecrosis." | 3.68 | Analysis of inflammatory cells and complement C3 in bupivacaine-induced myonecrosis. ( Arahata, K; Hiyamuta, E; Orimo, S; Sugita, H, 1991) |
| "To examine the behavior of transverse (T)-tubule formation in experimentally-induced regenerating fibers, a local anesthetic, bupivacaine hydrochloride, was injected directly into the rat soleus muscle to cause myonecrosis." | 3.67 | Behavior of sarcotubular system formation in experimentally induced regeneration of muscle fibers. ( Ishitsu, T; Miike, T; Nonaka, I; Ohtani, Y; Tamari, H, 1984) |
| "Injection of bupivacaine into the rat anterior tibial muscle produced rapid necrosis with disintegration of muscle fibres and phagocytic infiltration within two days." | 3.67 | Changes in end-plate cholinesterase and axons during muscle degeneration and regeneration. ( Czyzewski, K; Sadeh, M; Stern, LZ, 1985) |
| "Necrosis was verified by observations of swollen organelles, plasma membrane rupture, and cellular lysis under transmission electronic microscopy." | 1.48 | ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells. ( Cai, X; Hu, Y; Jiang, H; Liu, X; Liu, Y; Shao, Z; Xia, Y; Xiong, L; Yang, S, 2018) |
| "Bupivacaine and lower concentrations of lidocaine transiently alter Ca2+(cyt) homeostasis for several minutes, but without an immediate neurotoxic effect within 60 min." | 1.31 | Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model. ( DaSilva, AD; Gores, GJ; Johnson, ME; Saenz, JA; Uhl, CB, 2002) |
| "Necrosis was observed in the cervical area of two rabbits (one in the liposomal bupivacaine group and another in the phosphate buffer group)." | 1.30 | Neurotoxicological assessment after intracisternal injection of liposomal bupivacaine in rabbits. ( Alafandy, M; Benhamou, D; Couarraze, G; Coussaert, C; Legros, FJ; Malinovsky, JM; Mussini, JM; Pinaud, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (17.02) | 18.7374 |
| 1990's | 11 (23.40) | 18.2507 |
| 2000's | 12 (25.53) | 29.6817 |
| 2010's | 16 (34.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, X | 1 |
| Liu, Y | 1 |
| Hu, Y | 1 |
| Liu, X | 1 |
| Jiang, H | 1 |
| Yang, S | 1 |
| Shao, Z | 1 |
| Xia, Y | 1 |
| Xiong, L | 1 |
| Breu, A | 2 |
| Rosenmeier, K | 1 |
| Kujat, R | 2 |
| Angele, P | 2 |
| Zink, W | 5 |
| Hofmann, P | 2 |
| Metterlein, T | 2 |
| Bollwein, G | 2 |
| Gruber, M | 2 |
| Plank, C | 2 |
| Graf, BM | 3 |
| Eckl, S | 1 |
| Leite, PE | 1 |
| Gandía, L | 1 |
| de Pascual, R | 1 |
| Nanclares, C | 1 |
| Colmena, I | 1 |
| Santos, WC | 1 |
| Lagrota-Candido, J | 1 |
| Quirico-Santos, T | 1 |
| Mixa, V | 1 |
| Nedomova, B | 1 |
| Berka, I | 1 |
| Sadowski, SM | 1 |
| Andres, A | 1 |
| Morel, P | 1 |
| Schiffer, E | 1 |
| Frossard, JL | 1 |
| Platon, A | 1 |
| Poletti, PA | 1 |
| Bühler, L | 1 |
| Alessi Pissulin, CN | 1 |
| Henrique Fernandes, AA | 1 |
| Sanchez Orellana, AM | 1 |
| Rossi E Silva, RC | 1 |
| Michelin Matheus, SM | 1 |
| Dragoo, JL | 1 |
| Korotkova, T | 1 |
| Kanwar, R | 1 |
| Wood, B | 1 |
| Mohri, I | 1 |
| Aritake, K | 1 |
| Taniguchi, H | 1 |
| Sato, Y | 1 |
| Kamauchi, S | 1 |
| Nagata, N | 1 |
| Maruyama, T | 1 |
| Taniike, M | 1 |
| Urade, Y | 1 |
| Otrocka-Domagała, I | 2 |
| Rotkiewicz, T | 2 |
| Podbielski, M | 1 |
| Wiśniewska, A | 1 |
| Drzewiecka, A | 1 |
| Wetmore, BA | 1 |
| Brees, DJ | 1 |
| Singh, R | 1 |
| Watkins, PB | 1 |
| Andersen, ME | 1 |
| Loy, J | 1 |
| Thomas, RS | 1 |
| Farkas, B | 1 |
| Kvell, K | 1 |
| Czömpöly, T | 1 |
| Illés, T | 1 |
| Bárdos, T | 1 |
| Zhang, C | 1 |
| Phamonvaechavan, P | 1 |
| Rajan, A | 1 |
| Poon, DY | 1 |
| Topcu-Yilmaz, P | 1 |
| Guyton, DL | 1 |
| Lin, EP | 1 |
| Aronson, LA | 1 |
| Werdehausen, R | 1 |
| Braun, S | 1 |
| Fazeli, S | 1 |
| Hermanns, H | 1 |
| Hollmann, MW | 1 |
| Bauer, I | 1 |
| Stevens, MF | 1 |
| Mislovic, B | 1 |
| Mead, RN | 1 |
| Ryu, J | 1 |
| Liu, S | 1 |
| Ge, D | 1 |
| Lucas, J | 1 |
| Savoie, FH | 1 |
| You, Z | 1 |
| Smoot, EC | 1 |
| Colpitts, R | 1 |
| Johnson, ME | 1 |
| Saenz, JA | 1 |
| DaSilva, AD | 1 |
| Uhl, CB | 1 |
| Gores, GJ | 1 |
| Lee, HT | 1 |
| Krichevsky, IE | 1 |
| Xu, H | 1 |
| Ota-Setlik, A | 1 |
| D'Agati, VD | 1 |
| Emala, CW | 1 |
| Breschan, C | 1 |
| Kraschl, R | 1 |
| Jost, R | 1 |
| Marhofer, P | 1 |
| Likar, R | 1 |
| Karpińska, J | 1 |
| Purzyńska-Pugacewicz, A | 1 |
| Kasperowicz, B | 1 |
| Mikołajczyk, A | 1 |
| Babińska, I | 1 |
| Plant, DR | 1 |
| Beitzel, F | 1 |
| Lynch, GS | 1 |
| Bohl, JRE | 1 |
| Hacke, N | 1 |
| Sinner, B | 1 |
| Martin, E | 1 |
| Miike, T | 1 |
| Nonaka, I | 4 |
| Ohtani, Y | 1 |
| Tamari, H | 1 |
| Ishitsu, T | 1 |
| Takagi, A | 1 |
| Ishiura, S | 1 |
| Nakase, H | 1 |
| Sugita, H | 2 |
| Cumming, WJ | 1 |
| Hudgson, P | 1 |
| Saito, Y | 1 |
| Ono, K | 1 |
| Abe, J | 1 |
| Kagawa, N | 1 |
| Ii, K | 1 |
| Hizawa, K | 1 |
| Valdivielso Serna, A | 1 |
| González Bravo, MN | 1 |
| Monleón Luque, M | 1 |
| Casado Flores, J | 1 |
| Malinovsky, JM | 1 |
| Benhamou, D | 1 |
| Alafandy, M | 1 |
| Mussini, JM | 1 |
| Coussaert, C | 1 |
| Couarraze, G | 1 |
| Pinaud, M | 1 |
| Legros, FJ | 1 |
| Boezaart, AP | 1 |
| du Toit, JC | 1 |
| van Lill, G | 1 |
| Donald, R | 1 |
| van der Spuy, G | 1 |
| Bolus, M | 1 |
| Ozzeybek, D | 1 |
| Koca, U | 1 |
| Elar, Z | 1 |
| Olguner, M | 1 |
| Hakgüder, G | 1 |
| Groban, L | 1 |
| Zvara, DA | 1 |
| Deal, DD | 1 |
| Vernon, JC | 1 |
| Carpenter, RL | 1 |
| Khalyfa, A | 1 |
| Carlson, BM | 1 |
| Carlson, JA | 1 |
| Wang, E | 1 |
| Wakata, N | 1 |
| Sugimoto, H | 1 |
| Iguchi, H | 1 |
| Nomoto, N | 1 |
| Kinoshita, M | 1 |
| Duguez, S | 1 |
| Féasson, L | 1 |
| Denis, C | 1 |
| Freyssenet, D | 1 |
| Rezaian, SM | 1 |
| Shams, R | 1 |
| Rosenblatt, JD | 1 |
| Woods, RI | 1 |
| Akiyama, C | 1 |
| Kobayashi, S | 1 |
| Orimo, S | 1 |
| Hiyamuta, E | 1 |
| Arahata, K | 1 |
| Helliwell, TR | 1 |
| Wakayama, Y | 1 |
| Shibuya, S | 1 |
| Sadeh, M | 1 |
| Stern, LZ | 1 |
| Czyzewski, K | 1 |
| Glashan, RW | 1 |
| Brown, PR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance[NCT02139982] | Phase 1 | 110 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Skin temperature was measured at the thenar. change= 30min after brachial plexus block minus baseline (NCT02139982)
Timeframe: Baseline,30 min after brachial plexus block
| Intervention | ℃ (Mean) |
|---|---|
| Group A(Phase 2) | 1.18 |
| Group B(Phase 2) | 1.91 |
| Group C(Phase 2) | 2.27 |
| Group D(Phase 2) | 2.32 |
| Group E(Phase 2) | 2.44 |
| Group F(Phase 2) | 2.43 |
Success of Brachial Plexus Block(BPB) was defined as the absence of sensation to in all innervation areas of above four nerves (musculocutaneous, ulnar, radial, and median nerves) 30min. after the BPB and no pain during the surgery. (NCT02139982)
Timeframe: 30 min after brachial plexus block
| Intervention | participants (Number) |
|---|---|
| Group A(Phase 2) | 1 |
| Group B(Phase 2) | 9 |
| Group C(Phase 2) | 11 |
| Group D(Phase 2) | 12 |
| Group E(Phase 2) | 13 |
| Group F(Phase 2) | 13 |
The cross-sectional area(CSA, cm2) of Radial/ulnar Artery was assessed with B-mode imaging. Probe was kept perpendicular to the long axis of the artery to obtain the largest oval arterial section. The image at end diastole was chosen and measured with the cine loop. (NCT02139982)
Timeframe: baseline(t0), 30 min after specific nerve block(t1), 30 min after brachial plexus block(t2)
| Intervention | cm^2 (Mean) | |||||
|---|---|---|---|---|---|---|
| CSA of radial artery T0 | CSA of radial artery T1 | CSA of radial artery T2 | CAS of ulnar artery T0 | CAS of ulnar artery T1 | CAS of ulnar artery T2 | |
| Group MC(Phase 1) | 0.051 | 0.053 | 0.073 | 0.039 | 0.039 | 0.061 |
| Group ME (Phase 1) | 0.051 | 0.069 | 0.073 | 0.050 | 0.056 | 0.069 |
| Group RA (Phase 1) | 0.040 | 0.044 | 0.061 | 0.043 | 0.044 | 0.068 |
| Group UL( Phase 1) | 0.051 | 0.053 | 0.074 | 0.039 | 0.059 | 0.061 |
"These parameters included peak systolic velocity (PSV, cm/s), end-diastolic velocity (EDV, cm/s), time average maximum velocity (TAMAX), resistance index (RI), and pulsatility index (PI),The cross-sectional area of the artery imaging.Blood flow (BF) = TAMAX× CSA×60s.~Relative ratio of hemodymanic parameter=30 min after brachial plexus block divide by baseline" (NCT02139982)
Timeframe: baseline, 30 min after brachial plexus block
| Intervention | ratio (Median) | ||||
|---|---|---|---|---|---|
| relative ratio of PSV | Relative ratio of TAMAX | Relative ratio of BF | Relative ratio of PI | Relative ratio of RI | |
| Group A(Phase 2) | 1.031371 | 1.21 | 1.40 | 0.75 | 0.91 |
| Group B(Phase 2) | 1.15 | 1.56 | 1.87 | 0.61 | 0.87 |
| Group C(Phase 2) | 1.19 | 1.84 | 2.10 | 0.53 | 0.85 |
| Group D(Phase 2) | 1.19 | 2.09 | 2.54 | 0.47 | 0.84 |
| Group E(Phase 2) | 1.29 | 2.34 | 3.18 | 0.44 | 0.81 |
| Group F(Phase 2) | 1.43 | 2.57 | 3.53 | 0.43 | 0.82 |
These parameters included peak systolic velocity (PSV, cm/s), end-diastolic velocity (EDV, cm/s), time average maximum velocity (TAMAX),and was measured by Pulsed-wave Doppler(PWD) ultrasound. (NCT02139982)
Timeframe: baseline(t0), 30 min after specific nerve block(t1), 30 min after brachial plexus block(t2)
| Intervention | cm/s (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PSV of radial artery T0 | PSV of radial artery T1 | PSV of radial artery T2 | EDV of radial artery T0 | EDV of radial artery T1 | EDV of radial artery T2 | TAMAX of radial artery T0 | TAMAX of radial artery T1 | TAMAX of radial artery T2 | PSV of ulnar artery T0 | PSV of ulnar artery T1 | PSV of ulnar artery T2 | EDV of ulnar artery T0 | EDV of ulnar artery T1 | EDV of ulnar artery T2 | TAMAX of ulnar artery T0 | TAMAX of ulnar artery T1 | TAMAX of ulnar artery T2 | |
| Group MC(Phase 1) | 40.9 | 40.7 | 58.0 | 3.4 | 3.6 | 19.4 | 10.2 | 10.4 | 32.0 | 42.5 | 40.2 | 56.9 | 5.9 | 5.1 | 19.6 | 11.2 | 10.9 | 27.8 |
| Group ME (Phase 1) | 42.6 | 52.4 | 58.5 | 5.5 | 16.1 | 18.0 | 11.5 | 24.8 | 29.7 | 43.9 | 45.1 | 62.8 | 5.3 | 7.4 | 20.2 | 11.1 | 11.9 | 29.0 |
| Group RA (Phase 1) | 47.6 | 50.5 | 69.6 | 6.0 | 9.3 | 21.1 | 13.1 | 18.4 | 33.3 | 51.1 | 53.9 | 68.4 | 6.0 | 6.2 | 18.8 | 14.0 | 14.0 | 30.5 |
| Group UL( Phase 1) | 39.6 | 40.9 | 60.1 | 5.8 | 5.7 | 20.4 | 11.4 | 11.2 | 31.0 | 45.8 | 60.5 | 68.7 | 7.9 | 21.6 | 26.9 | 14.9 | 29.9 | 36.8 |
Skin temperature(Ts) was measured at four different points within the cutaneous innervation areas of the musculocutaneous(lateral skin of forearm), ulnar(hypothenar region), radial (thumb-index web) and median(thenar) Specific points were located with skin marker to provide consistency of measurement. (NCT02139982)
Timeframe: baseline, 30 min after specific nerve block, 30 min after brachial plexus block
| Intervention | ℃ (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ts MC t0 | Ts MC t1 | Ts MC t2 | Ts UL t0 | Ts UL t1 | Ts UL t2 | Ts RA t0 | Ts RA t1 | Ts RA t2 | Ts ME t0 | Ts ME t1 | Ts ME t2 | |
| Group MC(Phase 1) | 30.0 | 29.9 | 31.3 | 29.1 | 29.0 | 31.9 | 30.5 | 30.5 | 32.6 | 28.9 | 29.0 | 32.4 |
| Group ME (Phase 1) | 30.0 | 30.4 | 33.7 | 29.7 | 29.8 | 32.9 | 30.1 | 32.7 | 33.9 | 29.8 | 33.3 | 33.7 |
| Group RA (Phase 1) | 30.2 | 30.1 | 33.4 | 29.5 | 29.6 | 32.6 | 29.5 | 29.7 | 32.2 | 29.5 | 29.5 | 32.0 |
| Group UL( Phase 1) | 29.8 | 30.0 | 31.1 | 30.1 | 32.4 | 32.6 | 30.5 | 30.5 | 33.2 | 30.0 | 30.1 | 32.7 |
2 trials available for bupivacaine and Necrosis
| Article | Year |
|---|---|
Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis.
Topics: Abdominal Pain; Acute Disease; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, | 2015 |
Effect of butaphosphane and cyanocobalamin on regeneration of muscle fibres in pigs.
Topics: Animals; Bupivacaine; Muscle Fibers, Skeletal; Muscular Diseases; Necrosis; Organophosphonates; Orga | 2009 |
45 other studies available for bupivacaine and Necrosis
| Article | Year |
|---|---|
ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cell Death; Cell Survival; Cells, Cultured; Intervertebral | 2018 |
The cytotoxicity of bupivacaine, ropivacaine, and mepivacaine on human chondrocytes and cartilage.
Topics: Adult; Amides; Anesthetics, Local; Apoptosis; Bupivacaine; Cartilage; Caspases; Cell Survival; Cells | 2013 |
The myotoxic effect of bupivacaine and ropivacaine on myotubes in primary mouse cell culture and an immortalized cell line.
Topics: Amides; Anesthetics, Local; Animals; Apoptosis; Bupivacaine; Cell Death; Cell Line; Cell Survival; C | 2013 |
Cytotoxicity of local anesthetics on human mesenchymal stem cells in vitro.
Topics: Adolescent; Adult; Amides; Anesthetics, Local; Apoptosis; Bupivacaine; Cartilage; Cell Differentiati | 2013 |
Selective activation of α7 nicotinic acetylcholine receptor (nAChRα7) inhibits muscular degeneration in mdx dystrophic mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; | 2014 |
Modification of Bupivacaine-Induced Myotoxicity with Dantrolene and Caffeine In Vitro.
Topics: Anesthetics, Local; Animals; Annexins; Bupivacaine; Caffeine; Central Nervous System Stimulants; Dan | 2016 |
Continuous epidural analgesia, a new prospect in analgesia of newborns.
Topics: Amputation, Surgical; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cath | 2015 |
Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine.
Topics: Animals; Bupivacaine; Fibrosis; Low-Level Light Therapy; Muscular Diseases; Neck Muscles; Necrosis; | 2017 |
The effect of local anesthetics administered via pain pump on chondrocyte viability.
Topics: Anesthetics, Local; Bioreactors; Bupivacaine; Cells, Cultured; Chondrocytes; Epinephrine; Humans; In | 2008 |
Inhibition of prostaglandin D synthase suppresses muscular necrosis.
Topics: Anesthetics, Local; Animals; Blotting, Western; Bupivacaine; Cytokines; Disease Models, Animal; Huma | 2009 |
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Topics: Acetaminophen; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Anesthetics, Local; Animals | 2010 |
Increased chondrocyte death after steroid and local anesthetic combination.
Topics: Amides; Anesthetics, Local; Apoptosis; Betamethasone; Bupivacaine; Cell Survival; Cells, Cultured; C | 2010 |
Concentration-dependent bupivacaine myotoxicity in rabbit extraocular muscle.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2010 |
Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate.
Topics: Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; Bupivacaine; Cardiopulmonary Resuscit | 2010 |
Lipophilicity but not stereospecificity is a major determinant of local anaesthetic-induced cytotoxicity in human T-lymphoma cells.
Topics: Amides; Anesthetics, Local; Apoptosis; Bupivacaine; Cell Survival; Dose-Response Relationship, Drug; | 2012 |
Multimodal analgesia including infraclavicular block in perioperative management of upper extremity amputation in neonate.
Topics: Acetaminophen; Amputation, Surgical; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesth | 2011 |
Supraphysiologic temperature enhances cytotoxic effects of bupivacaine on bovine articular chondrocytes in an in vitro study.
Topics: Anesthetics, Local; Animals; Apoptosis; Bupivacaine; Cartilage, Articular; Cattle; Cell Survival; Ce | 2012 |
Wound complications of infusion pain pump therapy.
Topics: Anesthetics; Arthroplasty, Replacement, Knee; Bupivacaine; Drug Therapy, Combination; Epinephrine; H | 2002 |
Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model.
Topics: Anesthetics, Local; Animals; Bupivacaine; Calcium; Cell Membrane; Cells, Cultured; Dose-Response Rel | 2002 |
Local anesthetics worsen renal function after ischemia-reperfusion injury in rats.
Topics: Anesthetics, Local; Animals; Apoptosis; Blood Pressure; Bupivacaine; Gene Expression; Heart Rate; In | 2004 |
Axillary brachial plexus block for treatment of severe forearm ischemia after arterial cannulation in an extremely low birth-weight infant.
Topics: Amputation, Surgical; Anesthetics, Local; Brachial Plexus; Bupivacaine; Catheterization, Peripheral; | 2004 |
The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs.
Topics: Anesthetics, Local; Animal Feed; Animals; Antioxidants; Bupivacaine; Coenzymes; Female; Muscle, Skel | 2004 |
Length-tension relationships are altered in regenerating muscles of the rat after bupivacaine injection.
Topics: Adaptation, Physiological; Animals; Bupivacaine; Injections, Intramuscular; Isometric Contraction; M | 2005 |
The long term myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blocks.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Muscle Cells; Muscle Fibers, Skeletal; Muscle, Ske | 2005 |
Behavior of sarcotubular system formation in experimentally induced regeneration of muscle fibers.
Topics: Animals; Bupivacaine; Microscopy, Electron; Microtubules; Muscles; Muscular Diseases; Myofibrils; Ne | 1984 |
Pathophysiology of muscle fiber necrosis induced by bupivacaine hydrochloride (Marcaine).
Topics: Animals; Bupivacaine; Male; Microscopy, Electron; Muscles; Myofibrils; Necrosis; Phagocytosis; Rats; | 1983 |
Morphometric comparison of Duchenne's muscular dystrophy and experimental bupivacaine myopathy.
Topics: Animals; Biopsy; Bupivacaine; Child; Child, Preschool; Creatine Kinase; Humans; Muscles; Muscular Dy | 1981 |
Initiation of satellite cell replication in bupivacaine-induced myonecrosis.
Topics: Animals; Bromodeoxyuridine; Bupivacaine; Cell Division; Desmin; Muscles; Muscular Diseases; Necrosis | 1994 |
Immunohistochemical analysis of myoblast proliferation and differentiation in experimental skeletal muscle regeneration.
Topics: Animals; Autoantigens; Bupivacaine; Cell Differentiation; Cell Division; Desmin; Immunohistochemistr | 1993 |
[Digital ischemia of the lower limb: reversion via sympathetic blockage].
Topics: Anesthetics, Local; Bupivacaine; Female; Humans; Infant; Ischemia; Necrosis; Toes | 1997 |
Neurotoxicological assessment after intracisternal injection of liposomal bupivacaine in rabbits.
Topics: Anesthetics, Local; Animals; Blood-Brain Barrier; Bupivacaine; Drug Carriers; Injections, Spinal; Li | 1997 |
Urgent local anaesthetic drug alarm.
Topics: Adolescent; Adult; Anesthetics, Local; Bupivacaine; Fat Necrosis; Female; Humans; Male; Mydriasis; N | 1999 |
Glycerol trinitrate plus epidural sympathetic block in the ischemia of glans penis.
Topics: Anesthesia, Epidural; Anesthetics, Local; Anticoagulants; Autonomic Nerve Block; Bupivacaine; Child; | 1999 |
Thoracic epidural anesthesia reduces infarct size in a canine model of myocardial ischemia and reperfusion injury.
Topics: Anesthesia, Epidural; Anesthetics, Local; Animals; Blood Flow Velocity; Bupivacaine; Coronary Circul | 1999 |
Toxin injury-dependent switched expression between EF-1 alpha and its sister, S1, in rat skeletal muscle.
Topics: Actins; Anesthetics, Local; Animals; Blotting, Western; Bupivacaine; Ischemia; Muscle, Skeletal; Nec | 1999 |
Bupivacaine hydrochloride induces muscle fiber necrosis and hydroxyl radical formation-dimethyl sulphoxide reduces hydroxyl radical formation.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dimethyl Sulfoxide; Free Radical Scavengers; Hydroxyl Radi | 2001 |
Mitochondrial biogenesis during skeletal muscle regeneration.
Topics: Animals; Body Weight; Bupivacaine; Cell Differentiation; Cell Division; Citrate (si)-Synthase; Creat | 2002 |
The effect of Marcaine epidural anaesthesia on the spinal cord injured dog.
Topics: Anesthesia, Epidural; Animals; Bupivacaine; Dogs; Female; Male; Necrosis; Paraplegia | 1979 |
Hypertrophy of rat extensor digitorum longus muscle injected with bupivacaine. A sequential histochemical, immunohistochemical, histological and morphometric study.
Topics: Animals; Bupivacaine; Histocytochemistry; Hypertrophy; Immunohistochemistry; Male; Muscle Contractio | 1992 |
Comparison of behavior in muscle fiber regeneration after bupivacaine hydrochloride- and acid anhydride-induced myonecrosis.
Topics: Anhydrides; Animals; Bupivacaine; Male; Microscopy, Electron; Muscles; Necrosis; Nerve Fibers; Nerve | 1992 |
Analysis of inflammatory cells and complement C3 in bupivacaine-induced myonecrosis.
Topics: Animals; Antibodies, Monoclonal; Bupivacaine; Complement C3; Hindlimb; Immunohistochemistry; Inflamm | 1991 |
Lectin binding and desmin staining during bupivicaine-induced necrosis and regeneration in rat skeletal muscle.
Topics: Alkaline Phosphatase; Animals; Bupivacaine; Desmin; Lectins; Macrophages; Male; Muscles; Necrosis; R | 1988 |
Quantitative freeze-fracture electron-microscopic analysis of muscle plasma membrane of bupivacaine-induced myopathy.
Topics: Animals; Bupivacaine; Cell Membrane; Freeze Fracturing; Microscopy, Electron; Muscles; Muscular Dise | 1986 |
Changes in end-plate cholinesterase and axons during muscle degeneration and regeneration.
Topics: Animals; Axons; Bupivacaine; Cholinesterases; Histocytochemistry; Male; Motor Endplate; Muscles; Nec | 1985 |
Initial experience with Helmstein's treatment by a hydrostatic pressure technique in carcinoma of the bladder.
Topics: Aged; Biopsy; Bupivacaine; Cystoscopy; Female; Follow-Up Studies; Humans; Hypotension, Controlled; M | 1974 |