A proteasomal ubiquitin receptor ADRM1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16186]
110 kDa cell membrane glycoprotein;
Gp110;
Adhesion-regulating molecule 1;
ARM-1;
Proteasome regulatory particle non-ATPase 13;
hRpn13;
Rpn13 homolog
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| bortezomib | Homo sapiens (human) | IC50 | 0.5335 | 4 | 4 |
| carfilzomib | Homo sapiens (human) | IC50 | 0.0086 | 1 | 1 |
| belactosin a | Homo sapiens (human) | IC50 | 1.4200 | 2 | 2 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| protease binding | molecular function | Binding to a protease or a peptidase. [GOC:hjd] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| endopeptidase activator activity | molecular function | Binds to and increases the activity of an endopeptidase. [GOC:dph, GOC:tb] |
| proteasome binding | molecular function | Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation. [GOC:mah] |
| molecular function inhibitor activity | molecular function | A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| proteasome complex | cellular component | A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. [GOC:rb, Wikipedia:Proteasome] |
| proteasome regulatory particle, lid subcomplex | cellular component | The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. [GOC:rb] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| transcription elongation by RNA polymerase II | biological process | The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH] |
| proteasome-mediated ubiquitin-dependent protein catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:go_curators] |
| proteasome assembly | biological process | The aggregation, arrangement and bonding together of a mature, active proteasome complex. [GOC:go_curators, PMID:10872471] |