Guanine deaminase

A guanine deaminase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2T3]

Synonyms

Guanase;
Guanine aminase;
EC 3.5.4.3;
Guanine aminohydrolase;
GAH;
p51-nedasin

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (8)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
uric acid	Homo sapiens (human)	Ki	4.3400	1	1
xanthine	Homo sapiens (human)	Ki	1.9600	1	1
caffeine	Homo sapiens (human)	Ki	10.2000	1	1
aminoimidazole carboxamide	Homo sapiens (human)	Ki	4.4400	1	1
2,6-diaminopurine	Homo sapiens (human)	Ki	1.8800	1	1
7-methylxanthine	Homo sapiens (human)	Ki	5.5500	1	1
azepinomycin	Homo sapiens (human)	IC50	5.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
guanine	Homo sapiens (human)	Km	11.2100	1	1

Enables

This protein enables 2 target(s):

Target	Category	Definition
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
guanine deaminase activity	molecular function	Catalysis of the reaction: guanine + H2O = xanthine + NH3. [EC:3.5.4.3]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
allantoin metabolic process	biological process	The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. [GOC:mah, ISBN:0198547684]
nucleobase-containing compound metabolic process	biological process	Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai]
guanine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. [GOC:go_curators]
deoxyguanosine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. [GOC:jl]
nervous system development	biological process	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
amide catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:curators]
GMP catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate. [GOC:go_curators]
dGMP catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). [GOC:go_curators]
guanine metabolic process	biological process	The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. [GOC:go_curators]