Proteins > Histone deacetylase 9
Page last updated: 2024-08-07 17:30:45

Histone deacetylase 9

A histone deacetylase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKV0]

Synonyms

HD9;
EC 3.5.1.98;
Histone deacetylase 7B;
HD7;
HD7b;
Histone deacetylase-related protein;
MEF2-interacting transcription repressor MITR

Research

Bioassay Publications (231)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.43)18.2507
2000's51 (22.08)29.6817
2010's131 (56.71)24.3611
2020's48 (20.78)2.80

Compounds (78)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidHomo sapiens (human)Ki8.190011
butyric acidHomo sapiens (human)IC502,000.000011
butyric acidHomo sapiens (human)Ki136.000011
celecoxibHomo sapiens (human)IC501.637011
ci 994Homo sapiens (human)IC5023.2175512
ci 994Homo sapiens (human)Ki0.095013
clioquinolHomo sapiens (human)IC5071.0857114
valproic acidHomo sapiens (human)IC503,411.666733
valproic acidHomo sapiens (human)Ki564.000011
ebselenHomo sapiens (human)IC503.700011
fluconazoleHomo sapiens (human)IC5040.000011
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)IC500.833022
entinostatHomo sapiens (human)IC508.21892534
4-phenylbutyric acidHomo sapiens (human)IC502,000.000011
4-phenylbutyric acidHomo sapiens (human)Ki2.800011
pomiferinHomo sapiens (human)IC501.050011
pyroxamideHomo sapiens (human)IC505.100022
scriptaidHomo sapiens (human)IC500.630022
scriptaidHomo sapiens (human)Ki8.000011
4-phenylbutyric acid, sodium saltHomo sapiens (human)Ki6.340011
fenofibrateHomo sapiens (human)IC5075.000011
vorinostatHomo sapiens (human)IC506.1691183197
vorinostatHomo sapiens (human)Ki1.146044
benzohydroxamic acidHomo sapiens (human)IC5033.330011
acetylcysteineHomo sapiens (human)IC503,160.000011
camptothecinHomo sapiens (human)IC500.050011
osajinHomo sapiens (human)IC506.530011
lapatinibHomo sapiens (human)IC50100.000011
n-hydroxy-2,2-diphenylacetamideHomo sapiens (human)IC5013.905044
trapoxin aHomo sapiens (human)IC500.004733
e-z cinnamic acidHomo sapiens (human)Ki0.008211
trichostatin aHomo sapiens (human)IC500.57043757
trichostatin aHomo sapiens (human)Ki0.701333
caffeic acidHomo sapiens (human)IC502,540.000011
caffeic acidHomo sapiens (human)Ki10.840011
curcuminHomo sapiens (human)IC50187.000011
chlorogenic acidHomo sapiens (human)IC50258.333333
chlorogenic acidHomo sapiens (human)Ki0.135011
zd 6474Homo sapiens (human)IC5010.000033
desmethylanethol trithioneHomo sapiens (human)IC500.450022
5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinolHomo sapiens (human)IC5025.195018
ex 527Homo sapiens (human)IC50100.000011
sodium butyrateHomo sapiens (human)IC50360.000033
sodium butyrateHomo sapiens (human)Ki365.000011
5'-o-caffeoylquinic acidHomo sapiens (human)IC50185.200022
harmineHomo sapiens (human)IC5010.000033
aureusidinHomo sapiens (human)IC5018.500011
romidepsinHomo sapiens (human)IC5010.062666
romidepsinHomo sapiens (human)Ki1.100022
3',4'-dihydroxyauroneHomo sapiens (human)IC508.200011
psammaplin aHomo sapiens (human)IC500.027022
trichostatin cHomo sapiens (human)IC5023.630011
laq824Homo sapiens (human)IC500.030855
laq824Homo sapiens (human)Ki9.000022
indigo carmineHomo sapiens (human)IC50321.620022
tanespimycinHomo sapiens (human)IC501,000.000011
tubacinHomo sapiens (human)IC504.310022
tubacinHomo sapiens (human)Ki3.404622
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)IC500.014077
belinostatHomo sapiens (human)IC500.035755
belinostatHomo sapiens (human)Ki0.174733
sk-7041Homo sapiens (human)IC500.172011
panobinostatHomo sapiens (human)IC501.50711321
panobinostatHomo sapiens (human)Ki1.807844
hdac-42Homo sapiens (human)IC500.016011
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)IC506.1642312
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)Ki0.167213
n1-(2-aminophenyl)-n7-phenylheptanediamideHomo sapiens (human)IC5078.000011
bml 210Homo sapiens (human)IC5091.400055
n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamideHomo sapiens (human)IC501.060033
givinostatHomo sapiens (human)IC500.512011
givinostatHomo sapiens (human)Ki0.390022
methyl 3,5-di-o-caffeoyl quinateHomo sapiens (human)IC506.290022
r 306465Homo sapiens (human)IC500.017022
quisinostatHomo sapiens (human)IC500.015133
quisinostatHomo sapiens (human)Ki0.004622
abexinostatHomo sapiens (human)IC500.168011
chidamideHomo sapiens (human)IC505.789032
hc toxinHomo sapiens (human)IC500.430011
azumamide eHomo sapiens (human)IC5028.000011
cnf 2024Homo sapiens (human)IC501.000022
pci 34051Homo sapiens (human)IC5055.000022
cudc 101Homo sapiens (human)IC500.164474
largazoleHomo sapiens (human)IC509.165022
N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl esterHomo sapiens (human)IC500.050011
trichostatin rkHomo sapiens (human)IC50100.000011
jq1 compoundHomo sapiens (human)IC500.291011
tubastatin aHomo sapiens (human)IC5017.12601010
pracinostatHomo sapiens (human)IC505.063022
pracinostatHomo sapiens (human)Ki0.024011
acy-1215Homo sapiens (human)IC507.125088
cudc-907Homo sapiens (human)IC500.461655
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)IC504.360044
osimertinibHomo sapiens (human)IC501.000011
santacruzamate aHomo sapiens (human)IC505.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ci 994Homo sapiens (human)EC503.810011
entinostatHomo sapiens (human)EC501.000011
imatinibHomo sapiens (human)EC50100.000011
vorinostatHomo sapiens (human)EC503.430066
belinostatHomo sapiens (human)EC500.079022
kd 5170Homo sapiens (human)EC500.045011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)AC502.100011
pyroxamideHomo sapiens (human)AC507.900011
vorinostatHomo sapiens (human)AC503.100011
vorinostatHomo sapiens (human)INH0.188522
vorinostatHomo sapiens (human)Inhibition0.080011
trapoxin aHomo sapiens (human)AC500.010011
trichostatin aHomo sapiens (human)AC500.400011
trichostatin aHomo sapiens (human)Inhibition0.003511
romidepsinHomo sapiens (human)INH0.024411
largazoleHomo sapiens (human)INH0.572011

Enables

This protein enables 12 target(s):

TargetCategoryDefinition
transcription corepressor activitymolecular functionA transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
histone deacetylase activitymolecular functionCatalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]
protein kinase C bindingmolecular functionBinding to protein kinase C. [GOC:jl]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
histone H3K14 deacetylase activitymolecular functionCatalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. [PMID:28450737]
histone H3K9 deacetylase activitymolecular functionCatalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. [PMID:28450737]
protein lysine deacetylase activitymolecular functionCatalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]
histone H4K16 deacetylase activitymolecular functionCatalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. [GOC:vw, PMID:28450737]
histone deacetylase bindingmolecular functionBinding to histone deacetylase. [GOC:jl]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
RNA polymerase II-specific DNA-binding transcription factor bindingmolecular functionBinding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]
DNA-binding transcription factor bindingmolecular functionBinding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
histone deacetylase complexcellular componentA protein complex that possesses histone deacetylase activity. [GOC:mah]
transcription regulator complexcellular componentA protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]
histone methyltransferase complexcellular componentA multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. [GOC:bf]

Involved In

This protein is involved in 16 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
negative regulation of cytokine productionbiological processAny process that stops, prevents, or reduces the rate of production of a cytokine. [GOC:add, ISBN:0781735149]
response to amphetaminebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef]
inflammatory responsebiological processThe immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
heart developmentbiological processThe process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
neuron differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
B cell differentiationbiological processThe process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah]
cellular response to insulin stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
peptidyl-lysine deacetylationbiological processThe removal of an acetyl group from an acetylated lysine residue in a peptide or protein. [GOC:BHF, GOC:mah]
B cell activationbiological processThe change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]
cholesterol homeostasisbiological processAny process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
negative regulation of gene expression, epigeneticbiological processAn epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. [PMID:22243696]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
regulation of skeletal muscle fiber developmentbiological processAny process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm]
regulation of striated muscle cell differentiationbiological processAny process that modulates the frequency, rate or extent of striated muscle cell differentiation. [CL:0000737, GOC:ai]
positive regulation of cell migration involved in sprouting angiogenesisbiological processAny process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]