Compounds > wr 77913

Page last updated: 2024-11-13

wr 77913

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	23665708
MeSH ID	M0108237

Synonyms (9)

Synonym
wr-77913
1-amino-3-(phosphonothio)-2-propanol monosodium salt
phosphorothioic acid, s-(3-amino-2-hydroxypropyl) ester, monosodium salt
wr 77913
sodium hydrogen-s-(3-amino-2-hydroxypropyl) phosphorothioate
nsc 318809
2-propanol, 1-amino-3-(phosphonothio)-, monosodium salt
s-(3-amino-2-hydroxypropyl)phosporothioate
1-amino-3-(sodiophosphonothio)-2-propanol

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" The toxic LD50/30 was 3574 mg/kg."	( Toxicity and radiation protective effect of WR-77913 in BALB/c mice. Connor, AM; Grigsby, P; Mendiondo, OA, 1982)	0.26
" Toxicity assessments in the mouse yielded a LD50 of 297 mg/kg and in the rat 389 mg/kg."	( Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates. Ali-Osman, F; Chin, L; Dwyer-Hansen, L; Grunbaum, Z; Krohn, KA; Livesey, J; Nelson, N; Rasey, JS; Spence, AM; Stein, D, 1995)	0.29

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	11 (47.83)	18.7374
1990's	12 (52.17)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.25 (24.57)
Research Supply Index	3.22 (2.92)
Research Growth Index	4.47 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.25)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (4.17%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (95.83%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
amifostine anhydrous Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.. amifostine : An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.	5.56	23	0	diamine; organic thiophosphate	antioxidant; prodrug; radiation protective agent
tiopronin Tiopronin: Sulfhydryl acylated derivative of GLYCINE.	1.98	1	0	N-acyl-amino acid
galactose galactopyranose : The pyranose form of galactose.	3.99	4	0	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
sodium selenite disodium selenite : An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.	2.9	4	0	inorganic sodium salt; selenite salt	nutraceutical
homocysteine Homocysteine: A thiol-containing amino acid formed by a demethylation of METHIONINE.. homocysteine : A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.. L-homocysteine : A homocysteine that has L configuration.	1.98	1	0	amino acid zwitterion; homocysteine; serine family amino acid	fundamental metabolite; mouse metabolite
nsc 327729 S-2-(3-methylaminopropylamino)ethylphosphorothioic acid: structure given in first source	3.22	6	0
triiodothyronine L-homocysteine thiolactone : A thiolactone arising from formal condensation of the mercapto (sulfanyl) and carboxylic acid groups of L-homocysteine.	1.98	1	0	tetrahydrothiophenes; thiolactone	human metabolite
pantetheine Pantetheine: An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.. pantetheine : An amide obtained by formal condensation of the carboxy group of pantothenic acid and the amino group of cysteamine.	1.99	1	0	pantetheines; thiol	human metabolite; metabolite; mouse metabolite
pantethine pantethine: RN given refers to cpd without isomeric designation; structure. pantethine : An organic disulfide that consists of two molecules of pantothenic acid linked by amide bonds to a cysteamine disulfide bridging group.	1.99	1	0	organic disulfide	coenzyme; nutraceutical
aluminum Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.	1.97	1	0	boron group element atom; elemental aluminium; metal atom
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	3.07	1	0	cysteinium	fundamental metabolite
selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	1.98	1	0	chalcogen; nonmetal atom	micronutrient

Condition	Indicated	Relationship Strength	Studies	Trials
Experimental Neoplasms [description not available]	0	2.88	4	0
Experimental Radiation Injuries [description not available]	0	4.5	9	0
Benign Neoplasms, Brain [description not available]	0	1.98	1	0
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	0	1.98	1	0
Cataract, Membranous [description not available]	0	4.5	9	0
Cataract Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)	0	4.5	9	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	1.98	1	0
Cancer of Colon [description not available]	0	1.97	1	0
Colonic Neoplasms Tumors or cancer of the COLON.	0	1.97	1	0
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	0	1.97	1	0
Palsy [description not available]	0	1.97	1	0
Paralysis A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)	0	1.97	1	0