Proteins > Solute carrier family 22 member 12
Page last updated: 2024-08-07 19:51:28

Solute carrier family 22 member 12

A solute carrier family 22 member 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S37]

Synonyms

Organic anion transporter 4-like protein;
Renal-specific transporter;
RST;
Urate anion exchanger 1

Research

Bioassay Publications (10)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's5 (50.00)24.3611
2020's4 (40.00)2.80

Compounds (9)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
benzbromaroneHomo sapiens (human)IC500.869599
probenecidHomo sapiens (human)IC5068.195022
sulfinpyrazoneHomo sapiens (human)IC50100.000011
benzaroneHomo sapiens (human)IC502.800011
merbaroneHomo sapiens (human)IC505.400011
morinHomo sapiens (human)IC502.000011
morinHomo sapiens (human)Ki5.740011
6-hydroxybenzbromaroneHomo sapiens (human)IC500.179333
lesinuradHomo sapiens (human)IC507.475679

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
arhalofenateHomo sapiens (human)EC5012.000011

Enables

This protein enables 2 target(s):

TargetCategoryDefinition
urate transmembrane transporter activitymolecular functionEnables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. [GOC:ai]
PDZ domain bindingmolecular functionBinding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membranecellular componentThe region of the plasma membrane located at the apical end of the cell. [GOC:curators]
brush border membranecellular componentThe portion of the plasma membrane surrounding the brush border. [GOC:mah]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Involved In

This protein is involved in 9 target(s):

TargetCategoryDefinition
monoatomic ion transportbiological processThe directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
response to xenobiotic stimulusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
urate transportbiological processThe directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
cellular homeostasisbiological processAny process involved in the maintenance of an internal steady state at the level of the cell. [GOC:isa_complete, GOC:jl, ISBN:0395825172]
cellular response to insulin stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
urate metabolic processbiological processThe chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. [ISBN:0198506732]
transmembrane transportbiological processThe process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
renal urate salt excretionbiological processThe elimination of urate salt or uric acid from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. [GOC:jl, PMID:25287933, PMID:3906799, Wikipedia:Renal_physiology#Secretion]
organic anion transportbiological processThe directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc]