A DNA-3-methyladenine glycosylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29372]
EC 3.2.2.21;
3-alkyladenine DNA glycosylase;
3-methyladenine DNA glycosidase;
ADPG;
N-methylpurine-DNA glycosylase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| aurintricarboxylic acid | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| gossypol | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| mitoxantrone hydrochloride | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| morin | Homo sapiens (human) | IC50 | 2.6000 | 1 | 1 |
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| damaged DNA binding | molecular function | Binding to damaged DNA. [GOC:jl] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| DNA-3-methyladenine glycosylase activity | molecular function | Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] |
| DNA N-glycosylase activity | molecular function | Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. [GOC:elh, PMID:11554296] |
| DNA-7-methylguanine glycosylase activity | molecular function | Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site. [GOC:jl, PMID:16468998] |
| DNA-7-methyladenine glycosylase activity | molecular function | Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site. [GOC:jl, PMID:16468998] |
| DNA-3-methylguanine glycosylase activity | molecular function | Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site. [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] |
| alkylbase DNA N-glycosylase activity | molecular function | Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| mitochondrial nucleoid | cellular component | The region of a mitochondrion to which the DNA is confined. [GOC:jl] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| DNA alkylation repair | biological process | The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases. [PMID:10946226, PMID:35543797] |
| depurination | biological process | The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar. [GOC:ai] |
| base-excision repair | biological process | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. [ISBN:0815316194] |