NADP-dependent malic enzyme, mitochondrial

An NADP-dependent malic enzyme, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16798]

NADP-ME;
EC 1.1.1.40;
Malic enzyme 3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
succinic acid	Homo sapiens (human)	Activity	2,100.0000	1	1
fumaric acid	Homo sapiens (human)	Activity	960.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
malic enzyme activity	molecular function	Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. [ISBN:0198506732]
malate dehydrogenase (decarboxylating) (NADP+) activity	molecular function	Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. [EC:1.1.1.40]
oxaloacetate decarboxylase activity	molecular function	Catalysis of the reaction: oxaloacetate = pyruvate + CO2. [EC:1.1.1.38, EC:1.1.1.40, EC:4.1.1.112]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
NAD binding	molecular function	Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai]
NADP+ binding	molecular function	Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]

This protein is located in 2 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]

This protein is active in 1 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]

This protein is involved in 4 target(s):

Target	Category	Definition
pyruvate metabolic process	biological process	The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. [GOC:go_curators]
malate metabolic process	biological process	The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. [ISBN:0198506732]
aerobic respiration	biological process	The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590]
oxygen metabolic process	biological process	The chemical reactions and pathways involving diatomic oxygen (O2). [GOC:mah]