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Dihydrofolate reductase
A dihydrofolate reductase that is encoded in the genome of mouse. [PRO:DAN]
Synonyms
EC 1.5.1.3
Research
Bioassay Publications (37)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 25 (67.57) | 18.7374 |
| 1990's | 10 (27.03) | 18.2507 |
| 2000's | 2 (5.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.Journal of medicinal chemistry, , Jan-24, Volume: 35, Issue:2, 1992
Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).Journal of medicinal chemistry, , Volume: 31, Issue:6, 1988
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.Journal of medicinal chemistry, , Volume: 31, Issue:11, 1988
Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.Journal of medicinal chemistry, , Volume: 29, Issue:5, 1986
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.Journal of medicinal chemistry, , Volume: 28, Issue:2, 1985
Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids.Journal of medicinal chemistry, , Volume: 28, Issue:8, 1985
Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.Journal of medicinal chemistry, , Volume: 27, Issue:5, 1984
Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.Journal of medicinal chemistry, , Volume: 27, Issue:7, 1984
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity.Journal of medicinal chemistry, , Volume: 26, Issue:12, 1983
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.Journal of medicinal chemistry, , Volume: 25, Issue:7, 1982
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.Journal of medicinal chemistry, , Volume: 25, Issue:2, 1982
Methotrexate analogues. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase.Journal of medicinal chemistry, , Volume: 25, Issue:8, 1982
Methotrexate analogues. 13. Chemical and pharmacological studies on amide, hydrazide, and hydroxamic acid derivatives of the glutamate side chain.Journal of medicinal chemistry, , Volume: 24, Issue:5, 1981
Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.Journal of medicinal chemistry, , Volume: 29, Issue:5, 1986
Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.Journal of medicinal chemistry, , Volume: 27, Issue:5, 1984
Methotrexate analogues. 16. Importance of the side-chain amide carbonyl group as a structural determinant of biological activity.Journal of medicinal chemistry, , Volume: 25, Issue:12, 1982
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.Journal of medicinal chemistry, , Volume: 25, Issue:7, 1982
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990