Proteins > Group XIIB secretory phospholipase A2-like protein
Page last updated: 2024-08-07 20:54:30
Group XIIB secretory phospholipase A2-like protein
A group XIIB secretory phospholipase A2-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BX93]
Synonyms
Group XIII secretory phospholipase A2-like protein;
GXIII sPLA2-like;
sPLA2-GXIIB;
GXIIB
Research
Bioassay Publications (1)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| varespladib | Homo sapiens (human) | IC50 | 0.1225 | 2 | 2 |
Drugs with Other Measurements
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| phospholipase A2 activity | molecular function | Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
Involved In
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|
| phospholipid metabolic process | biological process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| lipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators] |
| arachidonic acid secretion | biological process | The controlled release of arachidonic acid from a cell or a tissue. [GOC:ai] |
| triglyceride homeostasis | biological process | Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. [GOC:BHF, GOC:mah] |
| cholesterol homeostasis | biological process | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators] |