Page last updated: 2024-08-07 14:44:04
Retinal dehydrogenase 1
An aldehyde dehydrogenase 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00352]
Synonyms
RALDH 1;
RalDH1;
EC 1.2.1.-;
EC 1.2.1.36;
ALDH-E1;
ALHDII;
Aldehyde dehydrogenase family 1 member A1;
Aldehyde dehydrogenase, cytosolic
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 4 (50.00) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nct-501 | Homo sapiens (human) | EC50 | 7.7900 | 1 | 1 |
Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.Journal of medicinal chemistry, , 03-10, Volume: 65, Issue:5, 2022
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.Journal of medicinal chemistry, , 10-11, Volume: 61, Issue:19, 2018
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.Journal of medicinal chemistry, , Feb-26, Volume: 58, Issue:4, 2015
Enables
This protein enables 10 target(s):
| Target | Category | Definition |
|---|
| retinal dehydrogenase activity | molecular function | Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. [EC:1.2.1.36] |
| aldehyde dehydrogenase (NAD+) activity | molecular function | Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. [EC:1.2.1.3] |
| GTPase activator activity | molecular function | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah] |
| androgen binding | molecular function | Binding to an androgen, a male sex hormone. [GOC:jl] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| aminobutyraldehyde dehydrogenase activity | molecular function | Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. [EC:1.2.1.19] |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity | molecular function | Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+. [PMID:9497334] |
| NAD binding | molecular function | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai] |
| 3-deoxyglucosone dehydrogenase activity | molecular function | Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH. [PMID:17175089, RHEA:67244] |
| benzaldehyde dehydrogenase (NAD+) activity | molecular function | Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. [EC:1.2.1.28] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| axon | cellular component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|
| retinoid metabolic process | biological process | The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. [ISBN:0198506732] |
| cellular aldehyde metabolic process | biological process | The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. [GOC:go_curators, ISBN:0198506732] |
| gamma-aminobutyric acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [GOC:ai] |
| fructosamine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. [GOC:jl, ISBN:0192801023] |
| maintenance of lens transparency | biological process | A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina. [GOC:nhn, PMID:22095752] |
| retinol metabolic process | biological process | The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] |
| cellular detoxification of aldehyde | biological process | Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:vw, PMID:25656103] |
| negative regulation of cold-induced thermogenesis | biological process | Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis. [PMID:27876809] |