A sodium/nucleoside cotransporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00337]
Concentrative nucleoside transporter 1;
CNT 1;
hCNT1;
Na(+)/nucleoside cotransporter 1;
Sodium-coupled nucleoside transporter 1;
Solute carrier family 28 member 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| uridine | Homo sapiens (human) | IC50 | 5.8000 | 1 | 1 |
| uridine | Homo sapiens (human) | Ki | 5.2000 | 1 | 1 |
| phlorhizin | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| adenosine | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| adenosine | Homo sapiens (human) | Ki | 1.8000 | 1 | 1 |
| tecadenoson | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| tecadenoson | Homo sapiens (human) | Ki | 37.0000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| purine nucleobase transmembrane transporter activity | molecular function | Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. [ISBN:0198506732] |
| nucleoside:sodium symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). [GOC:ai] |
| cytidine transmembrane transporter activity | molecular function | Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other. [GOC:go_curators] |
| uridine transmembrane transporter activity | molecular function | Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. [GOC:go_curators] |
| pyrimidine- and adenosine-specific:sodium symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in). [TC:2.A.41.2.3] |
| azole transmembrane transporter activity | molecular function | Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| nuclear speck | cellular component | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/] |
| brush border membrane | cellular component | The portion of the plasma membrane surrounding the brush border. [GOC:mah] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| cytidine transport | biological process | The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| uridine transmembrane transport | biological process | The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| azole transmembrane transport | biological process | The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] |
| pyrimidine-containing compound transmembrane transport | biological process | The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah] |
| nucleoside import across plasma membrane | biological process | The directed movement of nucleoside from outside of a cell, across the plasma membrane and into the cytosol. [PMID:21998139, PMID:30658162] |
| nucleoside transmembrane transport | biological process | The directed movement of nucleoside across a membrane. [GOC:pr, GOC:TermGenie] |
| purine nucleobase transmembrane transport | biological process | The process in which a purine nucleobase is transported across a membrane. [GO_REF:0000069, GOC:TermGenie] |
| pyrimidine nucleobase transport | biological process | The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |