Flavin reductase (NADPH)

A flavin reductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30043]

Synonyms

FR;
EC 1.5.1.30;
Biliverdin reductase B;
BVR-B;
1.3.1.24;
Biliverdin-IX beta-reductase;
Green heme-binding protein;
GHBP;
NADPH-dependent diaphorase;
NADPH-flavin reductase;
FLR

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (7)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
erythrosine	Homo sapiens (human)	Kd	0.1592	1	2
sulfasalazine	Homo sapiens (human)	Kd	0.4383	1	2
olsalazine	Homo sapiens (human)	Kd	0.0704	1	2
tamibarotene	Homo sapiens (human)	Kd	1.3802	1	2
febuxostat	Homo sapiens (human)	Kd	1.6259	1	2
deferasirox	Homo sapiens (human)	Kd	1.7041	1	2
ptc 124	Homo sapiens (human)	Kd	0.1998	1	2

Enables

This protein enables 9 target(s):

Target	Category	Definition
biliverdin reductase (NAD(P)H) activity	molecular function	Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+. [EC:1.3.1.24]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
FMN reductase (NAD(P)H) activity	molecular function	Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates. [EC:1.5.1.39]
peptidyl-cysteine S-nitrosylase activity	molecular function	Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein. [GOC:sp, PMID:20972425, PMID:20972426]
riboflavin reductase (NADPH) activity	molecular function	Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+. [RHEA:19377]
FMN reductase (NADPH) activity	molecular function	Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+. [RHEA:21624]
FMN reductase (NADH) activity	molecular function	Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+. [RHEA:21620]
biliberdin reductase NAD+ activity	molecular function	Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+. [RHEA:15797]
biliverdin reductase (NADPH) activity	molecular function	Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+. [RHEA:15793]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 3 target(s):

Target	Category	Definition
megakaryocyte differentiation	biological process	The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. [GOC:mah]
heme catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:jl]
negative regulation of insulin receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. [GOC:bf]