palytoxin has been researched along with Necrosis* in 3 studies
2 review(s) available for palytoxin and Necrosis
| Article | Year |
|---|---|
Palytoxin toxicology: animal studies.
Palytoxin and its derivatives have been implicated in toxic events in humans following ingestion or inhalation, and many studies on the toxicities of these substances to animals, via various routes of administration, have been described. In this report, the toxicity of palytoxin to animals has been reviewed, with comments on possible mechanisms of action. Information required for the risk assessment of palytoxin and its derivatives is by no means complete, and recommendations for further studies, which may better inform regulatory decisions regarding these substances, are also discussed. Topics: Acrylamides; Animals; Apoptosis; Arrhythmias, Cardiac; Carcinogens; Cnidarian Venoms; Dose-Response Relationship, Drug; Mutagens; Necrosis; Species Specificity; Toxicity Tests, Acute | 2011 |
A molecular biologic approach to cardiac toxicology.
Topics: Acrylamides; Animals; Calcium; Cnidarian Venoms; Coronary Disease; Doxorubicin; Egtazic Acid; Electron Spin Resonance Spectroscopy; Free Radicals; Guinea Pigs; Heart; Hypoxia; Isoproterenol; Myocardium; Necrosis; Rabbits; Rats; Xanthine Oxidase | 1983 |
1 other study(ies) available for palytoxin and Necrosis
| Article | Year |
|---|---|
In vitro approaches to evaluate palytoxin-induced toxicity and cell death in intestinal cells.
Palytoxin isolated from the genus Palythoa is the most potent marine toxin known. The aim of the present study was to quantify palytoxin-induced cellular injury in the human intestinal cell line Caco-2. Cellular damage was measured by evaluating cell proliferation, cell membrane permeability, cell morphology and apoptotic markers. Furthermore, changes in F-actin were studied after exposure of cells to increasing amounts of palytoxin. The results show that cell proliferation decreased in a concentration-dependent manner with a mean IC(50) value of about 0.1 nM. A noticeable increase of cell detachment correlated with cell rounding and F-actin depolymerization was observed in palytoxin-treated cells. Moreover LDH was released from the cells in a dose and time dependent manner, although under these conditions there was no propidium iodide uptake. On the other hand, palytoxin impaired mitochondrial activity but other apoptotic markers, such as DNA fragmentation or caspases activation, were not observed. The results obtained in this paper suggest that the effects of palytoxin in Caco-2 cells were very potent and unspecific, since a primary necrosis and a secondary apoptosis seem to occur under these conditions. Topics: Acrylamides; Actins; Apoptosis; Caco-2 Cells; Caspases; Cell Adhesion; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Cnidarian Venoms; DNA Fragmentation; Dose-Response Relationship, Drug; Enterocytes; Humans; Intestinal Mucosa; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Necrosis | 2008 |