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DNA topoisomerase 1
A type 1B DNA topoisomerase 1 that is encoded in the genome of mouse. [OMA:Q04750, PRO:DNx]
Synonyms
EC 5.6.2.1;
DNA topoisomerase I
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| camptothecin | Mus musculus (house mouse) | IC50 | 26.0000 | 2 | 2 |
| topotecan | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| sn 38 | Mus musculus (house mouse) | IC50 | 4.0000 | 1 | 1 |
| nidulalin a | Mus musculus (house mouse) | IC50 | 172.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| edotecarin | Mus musculus (house mouse) | EC50 | 0.0015 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| camptothecin | Mus musculus (house mouse) | MIC | 0.0860 | 1 | 1 |
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.Journal of medicinal chemistry, , May-10, Volume: 44, Issue:10, 2001
Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.Journal of natural products, , Volume: 64, Issue:2, 2001
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.Journal of medicinal chemistry, , May-20, Volume: 42, Issue:10, 1999