Page last updated: 2024-10-25

cimetidine and Necrosis

cimetidine has been researched along with Necrosis in 22 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"A preliminary trial was conducted to determine if cimetidine would prevent acetaminophen-induced hepatic necrosis."7.66Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice. ( Donn, KH; Grisham, JW; Rudd, GD, 1981)
"The abilities of antacid (Mylanta II), sucralfate, cimetidine, and ranitidine to protect the gastric mucosa against ethanol-induced necrosis were compared in a standardized, experimental rat model."3.67Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury. ( Gergely, H; Hollander, D; Stachura, J; Tarnawski, A, 1985)
"2 N sodium hydroxide, 25% sodium chloride, or boiling water produced extensive necrosis of the gastric mucosa."3.66Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. ( Hanchar, AJ; Lancaster, C; Nezamis, JE; Robert, A, 1979)
"Necrosis was assessed on the seventh postoperative day."1.28The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival. ( Amiss, LR; Angel, MF; Bardakjian, V; Morgan, RF; Wanebo, J, 1990)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199015 (68.18)18.7374
1990's6 (27.27)18.2507
2000's1 (4.55)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pabla, N1
Murphy, RF1
Liu, K1
Dong, Z1
Kolts, BE1
Langfitt, M1
Bloksma, N1
van de Wiel, P1
Hofhuis, F1
Kuper, F1
Willers, J1
Ueda, F1
Aratani, S1
Mimura, K1
Kimura, K1
Nomura, A1
Enomoto, H1
Luderschmidt, C1
Gutschow, K1
Baumeister, RG1
Albrich, W1
Eiermann, W1
Rudd, GD1
Donn, KH1
Grisham, JW1
Mitchell, MC2
Schenker, S1
Avant, GR1
Speeg, KV2
Menguy, R1
Ruiz Del Arbol, L1
Moreira, V1
Moreno, A1
Hernández Ranz, F1
Cano, A1
García Plaza, A1
Chmel, H1
Kosaka, N1
Tanaka, H1
Tomaru, A1
Ishii, A1
Shuto, K1
Al-Mustafa, ZH1
Al-Ali, AK1
Qaw, FS1
Abdul-Cader, Z1
Robert, A1
Nezamis, JE1
Lancaster, C1
Hanchar, AJ1
Angel, MF1
Wanebo, J1
Bardakjian, V1
Amiss, LR1
Morgan, RF1
Laudanno, OM1
Bedini, OA1
Cesolari, JA1
San Miguel, P1
Morini, G1
Ortolani, F1
Impicciatore, M1
Tarnawski, A1
Hollander, D1
Gergely, H1
Stachura, J1
Lacy, ER1
Davis, M1
Takeda, F1
Kitagawa, H1
Kohei, H1
Maldonado, AL1
Van Steenbergen, W1
Vanstapel, MJ1
Desmet, V1
Van Kerckvoorde, L1
De Keyzer, R1
Brijs, R1
Fevery, J1
De Groote, J1

Reviews

1 review available for cimetidine and Necrosis

ArticleYear
Protective agents for acetaminophen overdose.
    Seminars in liver disease, 1986, Volume: 6, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimet

1986

Other Studies

21 other studies available for cimetidine and Necrosis

ArticleYear
The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity.
    American journal of physiology. Renal physiology, 2009, Volume: 296, Issue:3

    Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Cation Transport Proteins; Cell Line

2009
Drugs and the liver.
    Comprehensive therapy, 1984, Volume: 10, Issue:12

    Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv

1984
Role of histamine in the antitumour activity of endotoxin.
    Cancer immunology, immunotherapy : CII, 1984, Volume: 17, Issue:1

    Topics: Animals; Cimetidine; Diphenhydramine; Endotoxins; Female; Glycoproteins; Histamine; Mice; Mice, Inbr

1984
Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric mucosal damage induced by various necrotizing agents in rats.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Cimetidine; Dinoprostone; Electrolytes; Ethanol; Gastric Acid; Gastric J

1984
[Cutaneous coumarin necrosis of the breast].
    Deutsche medizinische Wochenschrift (1946), 1983, Sep-16, Volume: 108, Issue:37

    Topics: 4-Hydroxycoumarins; Breast Diseases; Bromhexine; Cimetidine; Female; Furosemide; Humans; Middle Aged

1983
Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice.
    Research communications in chemical pathology and pharmacology, 1981, Volume: 32, Issue:2

    Topics: Acetaminophen; Animals; Cimetidine; Female; Guanidines; Liver; Mice; Necrosis

1981
Cimetidine protects against acetaminophen hepatotoxicity in rats.
    Gastroenterology, 1981, Volume: 81, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and

1981
The prophylaxis of stress ulceration.
    The New England journal of medicine, 1980, Feb-21, Volume: 302, Issue:8

    Topics: Animals; Antacids; Burns; Cimetidine; Gastric Mucosa; Guanidines; Humans; Intestinal Mucosa; Ischemi

1980
Bridging hepatic necrosis associated with cimetidine.
    The American journal of gastroenterology, 1980, Volume: 74, Issue:3

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Esophagitis, Peptic; Guanidines; Humans; L

1980
Fatal acute hepatic necrosis due to fluconazole.
    The American journal of medicine, 1995, Volume: 99, Issue:2

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cimetidine; Fatal Outcome; Fluconazole; Human

1995
Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion.
    Japanese journal of pharmacology, 1994, Volume: 65, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Benzoxepins; Cimetidine; Depression, Chemical; Duodenal Ulcer; Ethanol;

1994
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.
    Toxicology, 1997, Sep-05, Volume: 121, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic;

1997
Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.
    Gastroenterology, 1979, Volume: 77, Issue:3

    Topics: Animals; Antacids; Burns; Cimetidine; Ethanol; Female; Gastric Juice; Gastric Mucosa; Hydrochloric A

1979
The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1990, Volume: 103, Issue:5 ( Pt 1)

    Topics: Animals; Cimetidine; Disease Models, Animal; Injections, Intraperitoneal; Male; Necrosis; Postoperat

1990
Evidence of anti-oxidant role of sucralfate in gastric mucosal protection.
    The Italian journal of gastroenterology, 1990, Volume: 22, Issue:1

    Topics: Alum Compounds; Animals; Antioxidants; Cimetidine; Enprostil; Famotidine; Female; Free Radicals; Gas

1990
Histological examination of gastric mucosal lesions induced by isolation in saline and cimetidine treated rat.
    The Italian journal of gastroenterology, 1990, Volume: 22, Issue:6

    Topics: Animals; Cimetidine; Edema; Epithelium; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Hyperem

1990
Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury.
    The American journal of medicine, 1985, Aug-30, Volume: 79, Issue:2C

    Topics: Aluminum; Aluminum Hydroxide; Animals; Antacids; Anti-Ulcer Agents; Cimetidine; Drug Combinations; E

1985
Effects of absolute ethanol, misoprostol, cimetidine, and phosphate buffer on the morphology of rat gastric mucosae.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:2 Suppl

    Topics: Alprostadil; Animals; Anti-Ulcer Agents; Buffers; Cimetidine; Ethanol; Female; Gastric Mucosa; Gastr

1986
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
    Japanese journal of pharmacology, 1985, Volume: 38, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Buffers; Cimetidine; Dinoprostone; Ethanol;

1985
Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cimetidine; Dose-Response Relationship, Drug;

1985
Cimetidine-induced liver injury. Report of three cases.
    Journal of hepatology, 1985, Volume: 1, Issue:4

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Gastritis; Gastritis, Hypertrophic; Humans

1985