cimetidine has been researched along with Necrosis in 22 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A preliminary trial was conducted to determine if cimetidine would prevent acetaminophen-induced hepatic necrosis." | 7.66 | Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice. ( Donn, KH; Grisham, JW; Rudd, GD, 1981) |
| "The abilities of antacid (Mylanta II), sucralfate, cimetidine, and ranitidine to protect the gastric mucosa against ethanol-induced necrosis were compared in a standardized, experimental rat model." | 3.67 | Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury. ( Gergely, H; Hollander, D; Stachura, J; Tarnawski, A, 1985) |
| "2 N sodium hydroxide, 25% sodium chloride, or boiling water produced extensive necrosis of the gastric mucosa." | 3.66 | Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. ( Hanchar, AJ; Lancaster, C; Nezamis, JE; Robert, A, 1979) |
| "Necrosis was assessed on the seventh postoperative day." | 1.28 | The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival. ( Amiss, LR; Angel, MF; Bardakjian, V; Morgan, RF; Wanebo, J, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (68.18) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pabla, N | 1 |
| Murphy, RF | 1 |
| Liu, K | 1 |
| Dong, Z | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Bloksma, N | 1 |
| van de Wiel, P | 1 |
| Hofhuis, F | 1 |
| Kuper, F | 1 |
| Willers, J | 1 |
| Ueda, F | 1 |
| Aratani, S | 1 |
| Mimura, K | 1 |
| Kimura, K | 1 |
| Nomura, A | 1 |
| Enomoto, H | 1 |
| Luderschmidt, C | 1 |
| Gutschow, K | 1 |
| Baumeister, RG | 1 |
| Albrich, W | 1 |
| Eiermann, W | 1 |
| Rudd, GD | 1 |
| Donn, KH | 1 |
| Grisham, JW | 1 |
| Mitchell, MC | 2 |
| Schenker, S | 1 |
| Avant, GR | 1 |
| Speeg, KV | 2 |
| Menguy, R | 1 |
| Ruiz Del Arbol, L | 1 |
| Moreira, V | 1 |
| Moreno, A | 1 |
| Hernández Ranz, F | 1 |
| Cano, A | 1 |
| García Plaza, A | 1 |
| Chmel, H | 1 |
| Kosaka, N | 1 |
| Tanaka, H | 1 |
| Tomaru, A | 1 |
| Ishii, A | 1 |
| Shuto, K | 1 |
| Al-Mustafa, ZH | 1 |
| Al-Ali, AK | 1 |
| Qaw, FS | 1 |
| Abdul-Cader, Z | 1 |
| Robert, A | 1 |
| Nezamis, JE | 1 |
| Lancaster, C | 1 |
| Hanchar, AJ | 1 |
| Angel, MF | 1 |
| Wanebo, J | 1 |
| Bardakjian, V | 1 |
| Amiss, LR | 1 |
| Morgan, RF | 1 |
| Laudanno, OM | 1 |
| Bedini, OA | 1 |
| Cesolari, JA | 1 |
| San Miguel, P | 1 |
| Morini, G | 1 |
| Ortolani, F | 1 |
| Impicciatore, M | 1 |
| Tarnawski, A | 1 |
| Hollander, D | 1 |
| Gergely, H | 1 |
| Stachura, J | 1 |
| Lacy, ER | 1 |
| Davis, M | 1 |
| Takeda, F | 1 |
| Kitagawa, H | 1 |
| Kohei, H | 1 |
| Maldonado, AL | 1 |
| Van Steenbergen, W | 1 |
| Vanstapel, MJ | 1 |
| Desmet, V | 1 |
| Van Kerckvoorde, L | 1 |
| De Keyzer, R | 1 |
| Brijs, R | 1 |
| Fevery, J | 1 |
| De Groote, J | 1 |
1 review available for cimetidine and Necrosis
| Article | Year |
|---|---|
Protective agents for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimet | 1986 |
21 other studies available for cimetidine and Necrosis
| Article | Year |
|---|---|
The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Cation Transport Proteins; Cell Line | 2009 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Role of histamine in the antitumour activity of endotoxin.
Topics: Animals; Cimetidine; Diphenhydramine; Endotoxins; Female; Glycoproteins; Histamine; Mice; Mice, Inbr | 1984 |
Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric mucosal damage induced by various necrotizing agents in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Dinoprostone; Electrolytes; Ethanol; Gastric Acid; Gastric J | 1984 |
[Cutaneous coumarin necrosis of the breast].
Topics: 4-Hydroxycoumarins; Breast Diseases; Bromhexine; Cimetidine; Female; Furosemide; Humans; Middle Aged | 1983 |
Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice.
Topics: Acetaminophen; Animals; Cimetidine; Female; Guanidines; Liver; Mice; Necrosis | 1981 |
Cimetidine protects against acetaminophen hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and | 1981 |
The prophylaxis of stress ulceration.
Topics: Animals; Antacids; Burns; Cimetidine; Gastric Mucosa; Guanidines; Humans; Intestinal Mucosa; Ischemi | 1980 |
Bridging hepatic necrosis associated with cimetidine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Esophagitis, Peptic; Guanidines; Humans; L | 1980 |
Fatal acute hepatic necrosis due to fluconazole.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cimetidine; Fatal Outcome; Fluconazole; Human | 1995 |
Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion.
Topics: Animals; Anti-Ulcer Agents; Benzoxepins; Cimetidine; Depression, Chemical; Duodenal Ulcer; Ethanol; | 1994 |
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; | 1997 |
Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.
Topics: Animals; Antacids; Burns; Cimetidine; Ethanol; Female; Gastric Juice; Gastric Mucosa; Hydrochloric A | 1979 |
The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival.
Topics: Animals; Cimetidine; Disease Models, Animal; Injections, Intraperitoneal; Male; Necrosis; Postoperat | 1990 |
Evidence of anti-oxidant role of sucralfate in gastric mucosal protection.
Topics: Alum Compounds; Animals; Antioxidants; Cimetidine; Enprostil; Famotidine; Female; Free Radicals; Gas | 1990 |
Histological examination of gastric mucosal lesions induced by isolation in saline and cimetidine treated rat.
Topics: Animals; Cimetidine; Edema; Epithelium; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Hyperem | 1990 |
Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury.
Topics: Aluminum; Aluminum Hydroxide; Animals; Antacids; Anti-Ulcer Agents; Cimetidine; Drug Combinations; E | 1985 |
Effects of absolute ethanol, misoprostol, cimetidine, and phosphate buffer on the morphology of rat gastric mucosae.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Buffers; Cimetidine; Ethanol; Female; Gastric Mucosa; Gastr | 1986 |
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Buffers; Cimetidine; Dinoprostone; Ethanol; | 1985 |
Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cimetidine; Dose-Response Relationship, Drug; | 1985 |
Cimetidine-induced liver injury. Report of three cases.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Gastritis; Gastritis, Hypertrophic; Humans | 1985 |