Arachidonate 5-lipoxygenase-activating protein

An arachidonate 5-lipoxygenase-activating protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20292]

Synonyms

FLAP;
MK-886-binding protein

Research

Bioassay Publications (19)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (15.79)	18.2507
2000's	4 (21.05)	29.6817
2010's	12 (63.16)	24.3611
2020's	0 (0.00)	2.80

Compounds (11)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
acetaminophen	Homo sapiens (human)	IC50	44.0000	1	1
acetazolamide	Homo sapiens (human)	Ki	0.0025	1	1
zonisamide	Homo sapiens (human)	Ki	0.1170	1	1
zileuton	Homo sapiens (human)	IC50	0.5800	1	1
mk 0591	Homo sapiens (human)	IC50	0.0086	5	5
1-(2-chlorobenzyl)-2-(1-(4-isobutylphenyl)ethyl)-1h-benzimidazole	Homo sapiens (human)	IC50	0.3100	2	2
l 663536	Homo sapiens (human)	IC50	0.0250	13	13
topiramate	Homo sapiens (human)	Ki	0.0009	1	1
bwa 4c	Homo sapiens (human)	IC50	0.1100	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
psoralidin	Homo sapiens (human)	Kd	21.0000	1	1
p-Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe	Homo sapiens (human)	EC50	0.0059	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
arachidonate 5-lipoxygenase activity	molecular function	Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. [EC:1.13.11.34, RHEA:32307]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
enzyme activator activity	molecular function	Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
protein-containing complex binding	molecular function	Binding to a macromolecular complex. [GOC:jl]
arachidonic acid binding	molecular function	Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [GOC:ai]
glutathione transferase activity	molecular function	Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. [EC:2.5.1.18]
glutathione peroxidase activity	molecular function	Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. [EC:1.11.1.9, PMID:36771108]
leukotriene-C4 synthase activity	molecular function	Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). [EC:4.4.1.20, RHEA:17617]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
nuclear envelope	cellular component	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
nuclear membrane	cellular component	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nuclear envelope	cellular component	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
leukotriene production involved in inflammatory response	biological process	The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149]
positive regulation of acute inflammatory response	biological process	Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. [GOC:add]
leukotriene biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:go_curators]
lipoxygenase pathway	biological process	The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. [GOC:mah, PMID:17163881]
protein homotrimerization	biological process	The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. [GOC:hjd]
cellular response to calcium ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:mah]
cellular oxidant detoxification	biological process	Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. [GOC:dos, GOC:vw]

chemdatabank.com