Page last updated: 2024-08-07 21:46:51
Dihydrofolate reductase
[no definition available]
Synonyms
EC 1.5.1.3
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| isoniazid | Mycobacterium tuberculosis H37Rv | Ki | 0.0010 | 1 | 1 |
| trimethoprim | Mycobacterium tuberculosis H37Rv | IC50 | 88.0000 | 1 | 1 |
| methotrexate | Mycobacterium tuberculosis H37Rv | IC50 | 0.0174 | 3 | 3 |
Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents.Bioorganic & medicinal chemistry, , 04-01, Volume: 27, Issue:7, 2019
1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Design and Synthesis of a Focused Library of Diamino Triazines as Potential Mycobacterium tuberculosis DHFR Inhibitors.ACS medicinal chemistry letters, , Nov-12, Volume: 6, Issue:11, 2015