Proteins > Polyunsaturated fatty acid 5-lipoxygenase
Page last updated: 2024-08-07 15:56:42
Polyunsaturated fatty acid 5-lipoxygenase
A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of rat. [OMA:P12527, PRO:DNx]
Synonyms
EC 1.13.11.-;
Arachidonate 5-lipoxygenase;
5-LO;
5-lipoxygenase;
1.13.11.34
Research
Bioassay Publications (62)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 17 (27.42) | 18.7374 |
| 1990's | 37 (59.68) | 18.2507 |
| 2000's | 2 (3.23) | 29.6817 |
| 2010's | 6 (9.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (84)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aa 861 | Rattus norvegicus (Norway rat) | IC50 | 1.0450 | 2 | 2 |
| bufexamac | Rattus norvegicus (Norway rat) | IC50 | 13.5644 | 2 | 2 |
| ibuprofen | Rattus norvegicus (Norway rat) | IC50 | 57.0000 | 2 | 2 |
| indomethacin | Rattus norvegicus (Norway rat) | IC50 | 771.4000 | 5 | 5 |
| ketoconazole | Rattus norvegicus (Norway rat) | IC50 | 25.0000 | 1 | 1 |
| ly 171883 | Rattus norvegicus (Norway rat) | IC50 | 25.1000 | 4 | 4 |
| meclofenamic acid | Rattus norvegicus (Norway rat) | IC50 | 24.0000 | 2 | 2 |
| meclofenamate sodium anhydrous | Rattus norvegicus (Norway rat) | IC50 | 24.0000 | 3 | 3 |
| masoprocol | Rattus norvegicus (Norway rat) | IC50 | 0.7520 | 10 | 10 |
| pf 5901 | Rattus norvegicus (Norway rat) | IC50 | 17.3600 | 8 | 8 |
| sb 216995 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| sk&f 86002 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| 1-naphthol | Rattus norvegicus (Norway rat) | IC50 | 3.6000 | 1 | 1 |
| phenidone | Rattus norvegicus (Norway rat) | IC50 | 2.6591 | 11 | 11 |
| acridan | Rattus norvegicus (Norway rat) | IC50 | 1.6000 | 1 | 1 |
| phenothiazine | Rattus norvegicus (Norway rat) | IC50 | 1.4000 | 1 | 1 |
| dibenzylamine | Rattus norvegicus (Norway rat) | IC50 | 17.0000 | 1 | 1 |
| benzohydroxamic acid | Rattus norvegicus (Norway rat) | IC50 | 110.7340 | 3 | 3 |
| n,n-naphthaloylhydroxylamine | Rattus norvegicus (Norway rat) | IC50 | 14.0418 | 3 | 3 |
| oxamethacin | Rattus norvegicus (Norway rat) | IC50 | 7.5000 | 1 | 1 |
| nafazatrom | Rattus norvegicus (Norway rat) | IC50 | 17.1250 | 4 | 4 |
| bw-755c | Rattus norvegicus (Norway rat) | IC50 | 5.2390 | 10 | 10 |
| lonapalene | Rattus norvegicus (Norway rat) | IC50 | 0.6467 | 3 | 3 |
| tepoxalin | Rattus norvegicus (Norway rat) | IC50 | 0.6667 | 3 | 3 |
| zileuton | Rattus norvegicus (Norway rat) | IC50 | 0.9656 | 15 | 15 |
| wy 48252 | Rattus norvegicus (Norway rat) | IC50 | 3.3000 | 2 | 2 |
| tebufelone | Rattus norvegicus (Norway rat) | IC50 | 3.0000 | 1 | 1 |
| tenidap | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 1 | 1 |
| salicylhydroxamic acid | Rattus norvegicus (Norway rat) | IC50 | 30.0998 | 2 | 2 |
| phenoxazine | Rattus norvegicus (Norway rat) | IC50 | 0.3200 | 1 | 1 |
| ibuproxam | Rattus norvegicus (Norway rat) | IC50 | 19.0622 | 4 | 4 |
| a 78773 | Rattus norvegicus (Norway rat) | IC50 | 0.2980 | 1 | 1 |
| a-76745 | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 1 |
| 1-benzyl-1h-indazol-3-ol | Rattus norvegicus (Norway rat) | IC50 | 3.4000 | 1 | 1 |
| 3-indazolinone | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| cv 6504 | Rattus norvegicus (Norway rat) | IC50 | 0.0620 | 1 | 1 |
| fpl 55712 | Rattus norvegicus (Norway rat) | IC50 | 10.7550 | 2 | 2 |
| a 63162 | Rattus norvegicus (Norway rat) | IC50 | 0.3475 | 3 | 4 |
| dehydroacetic acid | Rattus norvegicus (Norway rat) | IC50 | 55.0000 | 1 | 1 |
| l 656224 | Rattus norvegicus (Norway rat) | IC50 | 0.0360 | 1 | 1 |
| sr 2640 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| wy 45911 | Rattus norvegicus (Norway rat) | IC50 | 1.4000 | 4 | 4 |
| rg 6866 | Rattus norvegicus (Norway rat) | IC50 | 0.1000 | 1 | 1 |
| bwa 137c | Rattus norvegicus (Norway rat) | IC50 | 0.4600 | 1 | 1 |
| ml-3000 | Rattus norvegicus (Norway rat) | IC50 | 3.6000 | 1 | 1 |
| naproxen | Rattus norvegicus (Norway rat) | IC50 | 17.0000 | 1 | 1 |
| n-benzyl-n-hydroxy-5-phenylpentamide | Rattus norvegicus (Norway rat) | IC50 | 0.0500 | 1 | 1 |
| cirsiliol | Rattus norvegicus (Norway rat) | IC50 | 0.0950 | 1 | 1 |
| 2-(phenylmethyl)-1-naphthol | Rattus norvegicus (Norway rat) | IC50 | 0.0160 | 4 | 4 |
| N-hydroxy-2-phenylacetamide | Rattus norvegicus (Norway rat) | IC50 | 200.0528 | 3 | 3 |
| e 3040 | Rattus norvegicus (Norway rat) | IC50 | 0.1650 | 2 | 2 |
| isoliquiritigenin | Rattus norvegicus (Norway rat) | IC50 | 35.0000 | 1 | 1 |
| caffeic acid | Rattus norvegicus (Norway rat) | IC50 | 43.0000 | 1 | 1 |
| sulindac | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| via 2291 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| l 663536 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| 4-nitrobenzohydroxamic acid | Rattus norvegicus (Norway rat) | IC50 | 22.9696 | 3 | 3 |
| quercetin | Rattus norvegicus (Norway rat) | IC50 | 1.9500 | 6 | 6 |
| acacetin | Rattus norvegicus (Norway rat) | IC50 | 123.2000 | 1 | 1 |
| 15-keto-5,8,11,13-eicosatetraenoic acid | Rattus norvegicus (Norway rat) | IC50 | 26.0000 | 1 | 1 |
| 15-hydroxy-5,8,11,13-eicosatetraenoic acid | Rattus norvegicus (Norway rat) | IC50 | 5.3500 | 3 | 3 |
| 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (s)-(e,z,z,z)-isomer | Rattus norvegicus (Norway rat) | IC50 | 3.4000 | 1 | 1 |
| naringenin chalcone | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| butein | Rattus norvegicus (Norway rat) | IC50 | 0.0046 | 1 | 1 |
| baicalein | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| 4'-hydroxychalcone | Rattus norvegicus (Norway rat) | IC50 | 230.0000 | 1 | 1 |
| 5-oxo-6,8,11,14-eicosatetraenoic acid | Rattus norvegicus (Norway rat) | IC50 | 18.0000 | 1 | 1 |
| calythropsin | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 1 |
| cinnamoylhydroxamic acid | Rattus norvegicus (Norway rat) | IC50 | 12.0075 | 3 | 3 |
| 2',4'-dihydroxychalcone | Rattus norvegicus (Norway rat) | IC50 | 400.0000 | 1 | 1 |
| 2',3,4-trihydroxychalcone | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| e 5110 | Rattus norvegicus (Norway rat) | IC50 | 4.3200 | 3 | 3 |
| l 651896 | Rattus norvegicus (Norway rat) | IC50 | 0.2500 | 1 | 1 |
| kme 4 | Rattus norvegicus (Norway rat) | IC50 | 2.6200 | 5 | 5 |
| ticolubant | Rattus norvegicus (Norway rat) | IC50 | 8.2000 | 1 | 1 |
| 13(S)-HODE | Rattus norvegicus (Norway rat) | IC50 | 82.0000 | 1 | 1 |
| ci 987 | Rattus norvegicus (Norway rat) | IC50 | 1.4000 | 1 | 1 |
| 2',4',6'-trihydroxychalcone | Rattus norvegicus (Norway rat) | IC50 | 140.0000 | 1 | 1 |
| sb 210313 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| piroxicam | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 5,6-dimethylbenzimidazole | Rattus norvegicus (Norway rat) | Ks | 320.0000 | 1 | 1 |
| ibuprofen | Rattus norvegicus (Norway rat) | Change | 50.0000 | 2 | 2 |
| indomethacin | Rattus norvegicus (Norway rat) | ID50 | 25.0000 | 1 | 1 |
| benzimidazole | Rattus norvegicus (Norway rat) | Ks | 3,200.0000 | 1 | 1 |
| phenidone | Rattus norvegicus (Norway rat) | ID50 | 0.4800 | 1 | 1 |
| 2-methylbenzimidazole | Rattus norvegicus (Norway rat) | Ks | 510.0000 | 1 | 1 |
| bw-755c | Rattus norvegicus (Norway rat) | Change | 10.5000 | 2 | 2 |
| zileuton | Rattus norvegicus (Norway rat) | Change | 0.3500 | 2 | 2 |
| zileuton | Rattus norvegicus (Norway rat) | ID50 | 0.1400 | 1 | 1 |
| 4(5)-phenylimidazole | Rattus norvegicus (Norway rat) | Ks | 1.7000 | 1 | 1 |
| wy 45911 | Rattus norvegicus (Norway rat) | Inhibition | 1.5300 | 1 | 1 |
| naproxen | Rattus norvegicus (Norway rat) | Change | 100.0000 | 2 | 2 |
| naproxen | Rattus norvegicus (Norway rat) | Inhibition | 20.0000 | 1 | 1 |
| l 663536 | Rattus norvegicus (Norway rat) | Inhibition | 10.0175 | 2 | 2 |
Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.ACS medicinal chemistry letters, , Aug-10, Volume: 8, Issue:8, 2017
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters.Journal of medicinal chemistry, , Volume: 30, Issue:2, 1987
Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 29, Issue:11, 1986
Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.Journal of medicinal chemistry, , Apr-16, Volume: 36, Issue:8, 1993
1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.Journal of medicinal chemistry, , Jun-25, Volume: 36, Issue:13, 1993
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.Journal of medicinal chemistry, , Jan-21, Volume: 37, Issue:2, 1994
Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.Journal of medicinal chemistry, , Oct-02, Volume: 35, Issue:20, 1992
Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.Bioorganic & medicinal chemistry letters, , Mar-26, Volume: 11, Issue:6, 2001
Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
4-hydroxythiazole inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Hydroxamic acid inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
4-hydroxythiazole inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Hydroxamic acid inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.Journal of medicinal chemistry, , Volume: 30, Issue:7, 1987
Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters.Journal of medicinal chemistry, , Volume: 30, Issue:2, 1987
Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.Bioorganic & medicinal chemistry letters, , Mar-26, Volume: 11, Issue:6, 2001
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones.Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.Journal of medicinal chemistry, , Volume: 30, Issue:7, 1987
Hydroxamic acid inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues.Journal of medicinal chemistry, , Volume: 30, Issue:2, 1987
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.Journal of medicinal chemistry, , Feb-12, Volume: 41, Issue:4, 1998
Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones.Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
4-hydroxythiazole inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.Journal of medicinal chemistry, , Volume: 30, Issue:7, 1987
Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Hydroxamic acid inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.European journal of medicinal chemistry, , May-01, Volume: 169, 2019
Recent development of lipoxygenase inhibitors as anti-inflammatory agents.MedChemComm, , Feb-01, Volume: 9, Issue:2, 2018
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 27, Issue:16, 2017
Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.European journal of medicinal chemistry, , Jan-27, Volume: 108, 2016
Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.Bioorganic & medicinal chemistry letters, , May-01, Volume: 17, Issue:9, 2007
(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.Journal of medicinal chemistry, , May-21, Volume: 41, Issue:11, 1998
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.Journal of medicinal chemistry, , Feb-12, Volume: 41, Issue:4, 1998
Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Jun-20, Volume: 40, Issue:13, 1997
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Bicyclic N-hydroxyurea inhibitors of 5-lipoxygenase: pharmacodynamic, pharmacokinetic, and in vitro metabolic studies characterizing N-hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Synthesis and 5-lipoxygenase inhibitory activities of some novel 2-substituted 5-benzofuran hydroxamic acids.Journal of medicinal chemistry, , Oct-14, Volume: 37, Issue:21, 1994
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.Journal of medicinal chemistry, , Apr-03, Volume: 35, Issue:7, 1992
Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
4-hydroxythiazole inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.Journal of medicinal chemistry, , Volume: 33, Issue:3, 1990
Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Synthesis and 5-lipoxygenase inhibitory activities of some novel 2-substituted 5-benzofuran hydroxamic acids.Journal of medicinal chemistry, , Oct-14, Volume: 37, Issue:21, 1994
Orally active hydroxamic acid inhibitors of leukotriene biosynthesis.Journal of medicinal chemistry, , Volume: 31, Issue:1, 1988
Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis.Journal of medicinal chemistry, , Volume: 31, Issue:10, 1988
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters.Journal of medicinal chemistry, , Volume: 30, Issue:2, 1987
Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
4-hydroxythiazole inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Hydroxamic acid inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
Hydroxamic acid inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Volume: 30, Issue:3, 1987
Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues.Journal of medicinal chemistry, , Volume: 30, Issue:2, 1987
Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.Journal of medicinal chemistry, , Jan-21, Volume: 37, Issue:2, 1994
Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.Journal of medicinal chemistry, , Apr-16, Volume: 36, Issue:8, 1993
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.Journal of medicinal chemistry, , Jan-21, Volume: 37, Issue:2, 1994
Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.Journal of medicinal chemistry, , Apr-16, Volume: 36, Issue:8, 1993
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990