Page last updated: 2024-08-07 16:52:57
Beta-lactamase TEM
A protein that is a translation product of any of the plasmid-encoded copies of the blaTEM gene in Escherichia coli. [PRO:DAN, UniProtKB:P62593]
Synonyms
EC 3.5.2.6;
IRT-4;
Penicillinase;
TEM-1;
TEM-16/CAZ-7;
TEM-2;
TEM-24/CAZ-6;
TEM-3;
TEM-4;
TEM-5;
TEM-6;
TEM-8/CAZ-2
Research
Bioassay Publications (24)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 15 (62.50) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
Compounds (22)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Molecular dynamics simulations of the TEM-1 beta-lactamase complexed with cephalothin.Journal of medicinal chemistry, , Feb-10, Volume: 48, Issue:3, 2005
N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Molecular dynamics simulations of the TEM-1 beta-lactamase complexed with cephalothin.Journal of medicinal chemistry, , Feb-10, Volume: 48, Issue:3, 2005
Benzopyranones with retro-amide side chains as (inhibitory) beta-lactamase substrates.Bioorganic & medicinal chemistry letters, , Oct-18, Volume: 14, Issue:20, 2004
[no title available]Journal of medicinal chemistry, , 08-08, Volume: 62, Issue:15, 2019
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:11, 2007
SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:6, 2007
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.Journal of medicinal chemistry, , Jul-27, Volume: 49, Issue:15, 2006
Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.Journal of medicinal chemistry, , Jul-01, Volume: 47, Issue:14, 2004
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-23, Volume: 11, Issue:8, 2001
SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:6, 2007
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-23, Volume: 11, Issue:8, 2001
6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:11, 2007
SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:6, 2007
Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.Bioorganic & medicinal chemistry letters, , Mar-25, Volume: 12, Issue:6, 2002
N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:1, 2010
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:9, 2007
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.Bioorganic & medicinal chemistry letters, , Mar-08, Volume: 14, Issue:5, 2004
6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 9, Issue:7, 1999
Synthesis and biological activity of 7-alkylidenecephems.Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995