Compounds > basic blue 99
Page last updated: 2024-12-07

basic blue 99

Description

Basic Blue 99: causes contact dermatitis; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID93377
SCHEMBL ID456881
MeSH IDM0180655

Synonyms (23)

Synonym
basic blue 99
einecs 268-544-3
benzenaminium, 3-((4-amino-6-bromo-5,8-dihydro-1-hydroxy-8-imino-5-oxo-2-naphtha- lenyl)amino)-n,n,n-trimethyl-, chloride
benzenaminium, 3-((4-amino-6-bromo-5,8-dihydro-1-hydroxy-8-imino-5-oxo-2-naphthalenyl)amino)-n,n,n-trimethyl-, chloride (1:1)
ci 56059
3-((4-amino-6-bromo-5,8-dihydro-1-hydroxy-8-imino-5-oxo-2-naphtyl)amino)-n,n,n-trimethylanilinium chloride
unii-p0u7vbc51e
3-((4-amino-6-bromo-5,8-dihydro-1-hydroxy-8-imino-5-oxo-2-naphtha- lenyl)amino)-n,n,n-trimethylbenzenaminium chloride
c.i. basic blue 99
p0u7vbc51e ,
68123-13-7
benzenaminium, 3-((4-amino-6-bromo-5,8-dihydro-1-hydroxy-8-imino-5-oxo-2-naphthalenyl)amino)-n,n,n-trimethyl-, chloride
FT-0622581
SCHEMBL456881
arianor steel blue 306004
jarocol steel blue
basic blue 99 [inci]
basicblue99
DTXSID60874042
[3-[(4,8-diamino-6-bromo-5-hydroxy-1-oxonaphthalen-2-ylidene)amino]phenyl]-trimethylazanium;chloride
Q27285971
arianor steel blue
CS-0434156

Research Excerpts

Overview

Basic Blue 99 is a direct, nonoxidative hair colorant used in temporary and semipermanent hair dyes.

ExcerptReferenceRelevance
"Basic Blue 99 is a direct, nonoxidative hair colorant used in temporary and semipermanent hair dyes. "( Final report on the safety assessment of Basic Blue 99.
, 2007)		2.05

Toxicity

ExcerptReferenceRelevance
" The toxic mode of action of Basic Blue 99 seems to be the induction of cell death, without genotoxic effects, but while the necrotic pathway is observed in HaCaT monolayer cell culture, was apoptosis seen in the Equivalent Human Epidermis (EHE) model."( Immortalized equivalent human epidermis as a platform to evaluation hair dyes toxicity: Efficiency comparison between 3D and monolayer culture.
Dorta, DJ; Maria-Engler, SS; Mini, CA; Oliveira, DP, 2020)		0.85
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (4 Product(s))

Product Categories

Product CategoryProducts
Beauty & Personal Care4

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Tints of Nature Henna Cream Hair Color Black -- 2.46 fl ozTints of NatureBeauty & Personal Careorange, citric acid, chamomile, ascorbic acid, basic blue 99, benzyl alcohol, citric acid, tocopherol, ethylhexylglycerin, tocopherol, henna, limonene, phenoxyethanol, sodium benzoate, sodium sulfite, triethanolamine, urea2024-11-29 10:47:42
Tints of Nature Henna Cream Hair Color Golden Blonde -- 2.46 fl ozTints of NatureBeauty & Personal Careorange, citric acid, chamomile, ascorbic acid, basic blue 99, benzyl alcohol, citric acid, tocopherol, ethylhexylglycerin, tocopherol, henna, limonene, phenoxyethanol, sodium benzoate, sodium sulfite, triethanolamine, urea2024-11-29 10:47:42
Tints of Nature Henna Cream Hair Color Golden Brown -- 2.46 fl ozTints of NatureBeauty & Personal Careorange, citric acid, chamomile, ascorbic acid, basic blue 99, benzyl alcohol, citric acid, tocopherol, ethylhexylglycerin, tocopherol, henna, limonene, phenoxyethanol, sodium benzoate, sodium sulfite, triethanolamine, urea2024-11-29 10:47:42
Tints of Nature Henna Cream Hair Color Light Brown -- 2.46 fl ozTints of NatureBeauty & Personal Careorange, citric acid, chamomile, ascorbic acid, basic blue 99, benzyl alcohol, citric acid, tocopherol, ethylhexylglycerin, tocopherol, henna, limonene, phenoxyethanol, sodium benzoate, sodium sulfite, triethanolamine, urea2024-11-29 10:47:42

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's2 (20.00)29.6817
2010's3 (30.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.05 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index42.51 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (20.00%)6.00%
Case Studies4 (40.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (40.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methylene blue
Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.. methylene blue : An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.		4.8440organic chloride saltacid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer
lawsone
lawsone: a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; structure; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye. lawsone : 1,4-Naphthoquinone carrying a hydroxy function at C-2. It is obtained from the leaves of Lawsonia inermis.		3.1610
tolonium chloride
Tolonium Chloride: A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.. tolonium chloride : An organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion. It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques.		4.8440
gentian violet
Gentian Violet: A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.. crystal violet : An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain.		4.8440organic chloride saltanthelminthic drug;
antibacterial agent;
antifungal agent;
antiseptic drug;
histological dye
neon
Neon: A noble gas with the atomic symbol Ne, atomic number 10, and atomic weight 20.18. It is found in the earth's crust and atmosphere as an inert, odorless gas and is used in vacuum tubes and incandescent lamps.		4.8440monoatomic neon;
noble gas atom;
p-block element atom
helium
Helium: A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics.		4.8440monoatomic helium;
noble gas atom;
s-block element atom		food packaging gas
basic red 51
Basic Red 51: a semi-permanent hair dye, cytotoxic to human skin cells; structure in first source		2.2510
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.1610aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		7.51130
aluminum
Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.		4.8440boron group element atom;
elemental aluminium;
metal atom
aluminum phthalocyanine disulfonate
[no description available]		4.8440
ConditionIndicatedRelationship StrengthStudiesTrials
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.2510
Allergic Contact Dermatitis
[description not available]		02.5220
Anaphylactic Reaction
[description not available]		02.1510
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.		07.1510
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		02.5220
Dermatitis, Occupational
A recurrent contact dermatitis caused by substances found in the work place.		02.110
Symptom Cluster
[description not available]		02.110
Hives
[description not available]		03.6430
Syndrome
A characteristic symptom complex.		02.110
Urticaria
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.		08.6430
Contact Dermatitis
[description not available]		03.6130
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		03.6130
Allergic Conjunctivitis
[description not available]		01.9910
Atopic Hypersensitivity
[description not available]		01.9910
Conjunctivitis, Allergic
Conjunctivitis due to hypersensitivity to various allergens.		01.9910
Dental Deposit
[description not available]		07.34160
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