Proteins > Quinolone resistance protein NorA
Page last updated: 2024-08-07 23:15:04
Quinolone resistance protein NorA
[no definition available]
Synonyms
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| celecoxib | Staphylococcus aureus | IC50 | 40.0000 | 1 | 1 |
| nicardipine | Staphylococcus aureus | IC50 | 22.8000 | 1 | 1 |
| reserpine | Staphylococcus aureus | IC50 | 8.5429 | 7 | 7 |
| paroxetine | Staphylococcus aureus | IC50 | 7.0000 | 1 | 1 |
| totarol | Staphylococcus aureus | IC50 | 15.0000 | 1 | 1 |
| gefitinib | Staphylococcus aureus | IC50 | 9.7000 | 1 | 1 |
| dasatinib | Staphylococcus aureus | IC50 | 11.5000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| reserpine | Staphylococcus aureus | MMC | 6.5700 | 1 | 1 |
| 2-phenylindole | Staphylococcus aureus | MIC | 162.0000 | 2 | 2 |
2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction.Journal of medicinal chemistry, , 09-13, Volume: 61, Issue:17, 2018
Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms.Journal of medicinal chemistry, , 10-26, Volume: 60, Issue:20, 2017
Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: study of 6-substituted pyridine-3-boronic acid derivatives.European journal of medicinal chemistry, , May-05, Volume: 95, 2015
Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.Journal of medicinal chemistry, , Jun-27, Volume: 56, Issue:12, 2013
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles.Bioorganic & medicinal chemistry, , Jul-15, Volume: 20, Issue:14, 2012
Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.Journal of medicinal chemistry, , Aug-25, Volume: 54, Issue:16, 2011
The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:12, 2007