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Oligo-1,6-glucosidase IMA1
A protein that is a translation product of the IMA1 gene in yeast. [PRO:DNx, UniProtKB:P53051]
Synonyms
EC 3.2.1.10;
Alpha-glucosidase;
Isomaltase 1
Research
Bioassay Publications (21)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 19 (90.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| dicarbethoxydihydrocollidine | Saccharomyces cerevisiae S288C | IC50 | 50.0000 | 1 | 1 |
| 1-deoxynojirimycin | Saccharomyces cerevisiae S288C | IC50 | 330.0000 | 1 | 1 |
| acarbose | Saccharomyces cerevisiae S288C | IC50 | 415.9700 | 9 | 10 |
| 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine | Saccharomyces cerevisiae S288C | IC50 | 50.0000 | 1 | 1 |
| diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | Saccharomyces cerevisiae S288C | IC50 | 35.0000 | 1 | 1 |
| diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | Saccharomyces cerevisiae S288C | Ki | 25.0000 | 1 | 1 |
| 2-(4-hydroxyphenyl)-4,5-diphenylimidazole | Saccharomyces cerevisiae S288C | IC50 | 97.1200 | 1 | 1 |
| miglitol | Saccharomyces cerevisiae S288C | IC50 | 9,900.0000 | 1 | 1 |
| acarbose | Saccharomyces cerevisiae S288C | IC50 | 167.6571 | 7 | 7 |
| n-nonyl-1-deoxynojirimycin | Saccharomyces cerevisiae S288C | IC50 | 100.0000 | 1 | 1 |
| 2',3-dihydroxychalcone | Saccharomyces cerevisiae S288C | IC50 | 44.6600 | 1 | 1 |
| quercetin | Saccharomyces cerevisiae S288C | IC50 | 530.0000 | 1 | 1 |
| 3-methylquercetin | Saccharomyces cerevisiae S288C | IC50 | 160.0000 | 1 | 1 |
| butylidenephthalide | Saccharomyces cerevisiae S288C | IC50 | 2,350.0000 | 1 | 1 |
| butylidenephthalide | Saccharomyces cerevisiae S288C | Ki | 4.8600 | 1 | 1 |
In search of new α-glucosidase inhibitors: Imidazolylpyrazole derivatives.Bioorganic chemistry, , Volume: 71, 2017
Green synthesis, inhibition studies of yeast α-glucosidase and molecular docking of pyrazolylpyridazine amines.Bioorganic chemistry, , Volume: 71, 2017
Synthesis, molecular docking studies of hybrid benzimidazole as α-glucosidase inhibitor.Bioorganic chemistry, , Volume: 70, 2017
Synthesis, α-glucosidase inhibitory, cytotoxicity and docking studies of 2-aryl-7-methylbenzimidazoles.Bioorganic chemistry, , Volume: 65, 2016
Dihydropyrano [2,3-c] pyrazole: Novel in vitro inhibitors of yeast α-glucosidase.Bioorganic chemistry, , Volume: 65, 2016
Synthesis, In vitro and Docking Studies of New Flavone Ethers as α-Glucosidase Inhibitors.Chemical biology & drug design, , Volume: 87, Issue:3, 2016
Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies.Bioorganic chemistry, , Volume: 64, 2016
Synthesis and biological evaluation of novel 2,4,5-triarylimidazole-1,2,3-triazole derivatives via click chemistry as α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 26, Issue:23, 2016
Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer's disease: In vitro studies against yeast α-glucosidase, acetylcholinesterase and butyrylcholinesterase.Bioorganic chemistry, , Volume: 63, 2015
Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase.Bioorganic chemistry, , Volume: 62, 2015
Organocatalyzed solvent free an efficient novel synthesis of 2,4,5-trisubstituted imidazoles for α-glucosidase inhibition to treat diabetes.Bioorganic chemistry, , Volume: 58, 2015
Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 25, Issue:7, 2015
Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and α-Glucosidase.Journal of natural products, , Aug-28, Volume: 78, Issue:8, 2015
Triazinoindole analogs as potent inhibitors of α-glucosidase: synthesis, biological evaluation and molecular docking studies.Bioorganic chemistry, , Volume: 58, 2015
Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 22, Issue:3, 2014
Synthesis and α-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-β-d-glucopyranosides.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013