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D(2) dopamine receptor
[no definition available]
Synonyms
Dopamine D2 receptor
Research
Bioassay Publications (29)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 16 (55.17) | 18.7374 |
| 1990's | 11 (37.93) | 18.2507 |
| 2000's | 2 (6.90) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (40)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 8-hydroxy-2-(di-n-propylamino)tetralin | Bos taurus (cattle) | IC50 | 0.8000 | 2 | 2 |
| buspirone | Bos taurus (cattle) | IC50 | 4.0000 | 2 | 3 |
| chlorpromazine | Bos taurus (cattle) | IC50 | 0.5328 | 5 | 5 |
| adtn | Bos taurus (cattle) | IC50 | 0.0060 | 1 | 1 |
| fenoldopam | Bos taurus (cattle) | IC50 | 1.5800 | 1 | 2 |
| fenoldopam | Bos taurus (cattle) | Ki | 0.7900 | 1 | 1 |
| haloperidol | Bos taurus (cattle) | IC50 | 0.1332 | 4 | 4 |
| haloperidol | Bos taurus (cattle) | Ki | 0.0070 | 3 | 3 |
| metoclopramide | Bos taurus (cattle) | Ki | 0.0800 | 1 | 1 |
| promazine | Bos taurus (cattle) | IC50 | 0.1300 | 1 | 1 |
| ropinirole | Bos taurus (cattle) | IC50 | 6.8100 | 1 | 2 |
| 3-(3-cyanophenyl)-n-n-propylpiperidine | Bos taurus (cattle) | Ki | 1.1830 | 2 | 4 |
| apomorphine | Bos taurus (cattle) | IC50 | 0.3385 | 11 | 13 |
| apomorphine | Bos taurus (cattle) | Ki | 0.1019 | 2 | 2 |
| pergolide | Bos taurus (cattle) | IC50 | 0.0603 | 2 | 3 |
| pergolide mesylate | Bos taurus (cattle) | IC50 | 0.0500 | 1 | 1 |
| quinpirole | Bos taurus (cattle) | Ki | 1.3798 | 3 | 3 |
| preclamol | Bos taurus (cattle) | Ki | 0.2384 | 2 | 4 |
| ipsapirone | Bos taurus (cattle) | IC50 | 1,000.0000 | 2 | 3 |
| n 0437, (-)-isomer | Bos taurus (cattle) | Ki | 0.0150 | 1 | 1 |
| etisulergine | Bos taurus (cattle) | IC50 | 0.0820 | 4 | 5 |
| agroclavine | Bos taurus (cattle) | IC50 | 0.8900 | 1 | 1 |
| 4-phenyl-1,2,3,6-tetrahydropyridine | Bos taurus (cattle) | IC50 | 5.0000 | 1 | 1 |
| msh release-inhibiting hormone | Bos taurus (cattle) | Ki | 0.0340 | 7 | 8 |
| 2-(n,n-dimethylamino)-6,7-dihydroxytetralin | Bos taurus (cattle) | Ki | 0.2550 | 1 | 1 |
| aj 76 | Bos taurus (cattle) | Ki | 0.1515 | 2 | 2 |
| 2-methoxy-n-n-propylnorapomorphine | Bos taurus (cattle) | Ki | 0.0038 | 1 | 1 |
| 3-propylamino-5-hydroxychroman | Bos taurus (cattle) | IC50 | 0.4000 | 1 | 1 |
| sk&f 89124 | Bos taurus (cattle) | IC50 | 0.5300 | 1 | 2 |
| n-n-propylnorapomorphine | Bos taurus (cattle) | Ki | 0.0015 | 1 | 1 |
| 4-phenyl-1-(4-phenylbutyl)piperidine | Bos taurus (cattle) | IC50 | 0.3350 | 1 | 1 |
| 5-methoxy-3-(di-n-propylamino)chroman | Bos taurus (cattle) | IC50 | 0.1000 | 2 | 5 |
| quinagolide | Bos taurus (cattle) | IC50 | 12.0760 | 6 | 10 |
| preclamol | Bos taurus (cattle) | Ki | 4.8767 | 3 | 3 |
| l 745870 | Bos taurus (cattle) | Ki | 6.1000 | 1 | 1 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Bos taurus (cattle) | IC50 | 0.8737 | 3 | 3 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Bos taurus (cattle) | Ki | 0.0022 | 1 | 1 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Bos taurus (cattle) | Ki | 0.0012 | 1 | 1 |
| 7-hydroxy-2-n,n-dipropylaminotetralin, (r)-isomer | Bos taurus (cattle) | Ki | 0.0050 | 1 | 1 |
| uh 232 | Bos taurus (cattle) | Ki | 0.0155 | 2 | 2 |
| fauc 113 | Bos taurus (cattle) | Ki | 4.7000 | 1 | 1 |
| clozapine | Bos taurus (cattle) | IC50 | 1.8040 | 5 | 5 |
| clozapine | Bos taurus (cattle) | Ki | 0.6900 | 1 | 1 |
| flumezapine | Bos taurus (cattle) | IC50 | 0.0200 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| adtn | Bos taurus (cattle) | K Bind | 0.2100 | 1 | 1 |
| adtn | Bos taurus (cattle) | Kb | 0.2100 | 1 | 1 |
| sk&f-38393 | Bos taurus (cattle) | K bind | 33.9000 | 1 | 1 |
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans].Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans].Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
Synthesis and dopamine antagonist activity of 2-thioether derivatives of the ergoline ring system.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
Synthesis and pharmacological evaluation of conformationally restricted phenothiazine analogues.Journal of medicinal chemistry, , Volume: 25, Issue:1, 1982
Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine.Journal of medicinal chemistry, , Volume: 23, Issue:8, 1980
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980
Synthesis and dopaminergic activity of some halogenated mono- and dihydroxylated 2-aminotetralins.Journal of medicinal chemistry, , Volume: 29, Issue:9, 1986
Dopamine receptor agonist activity of some 5-(2-aminoethyl)carbostyril derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
Synthesis and dopamine receptor binding of exo- and endo-2-amino-6,7-dihydroxybenzonorbornene, rigid analogues of 2-amino-6,7-dihydroxytetrahydronaphthalene.Journal of medicinal chemistry, , Volume: 25, Issue:7, 1982
Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzothiazol-2-one 7-ethylamines.Journal of medicinal chemistry, , Volume: 30, Issue:7, 1987
Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Synthesis and dopamine antagonist activity of 2-thioether derivatives of the ergoline ring system.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.Journal of medicinal chemistry, , Oct-15, Volume: 36, Issue:21, 1993
Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzim idazolone derivatives.Journal of medicinal chemistry, , Volume: 30, Issue:5, 1987
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:3, 1989
Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Aporphines. 39. Synthesis, dopamine receptor binding, and pharmacological activity of (R)-(-)- and (S)-(+)-2-hydroxyapomorphine.Journal of medicinal chemistry, , Volume: 25, Issue:8, 1982
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans].Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one: synthesis and pharmacological activity.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans].Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Aporphines. 39. Synthesis, dopamine receptor binding, and pharmacological activity of (R)-(-)- and (S)-(+)-2-hydroxyapomorphine.Journal of medicinal chemistry, , Volume: 25, Issue:8, 1982
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.Bioorganic & medicinal chemistry letters, , Jan-04, Volume: 9, Issue:1, 1999
Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
Synthesis and dopamine antagonist activity of 2-thioether derivatives of the ergoline ring system.Journal of medicinal chemistry, , Apr-02, Volume: 36, Issue:7, 1993
Synthesis and pharmacological evaluation of CNS activities of [1,2,3]triazolo[4,5-b][1,5]-, imidazolo[4,5-b][1,5]-, and pyrido[2,3-b][1,5]benzodiazepines. 10-Piperazinyl-4H-1,2,3-triazolo[4,5-b][1,5]benzodiazepines with neuroleptic activity.Journal of medicinal chemistry, , Volume: 32, Issue:10, 1989
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.Journal of medicinal chemistry, , Volume: 23, Issue:9, 1980
Synthesis and pharmacological evaluation of CNS activities of [1,2,3]triazolo[4,5-b][1,5]-, imidazolo[4,5-b][1,5]-, and pyrido[2,3-b][1,5]benzodiazepines. 10-Piperazinyl-4H-1,2,3-triazolo[4,5-b][1,5]benzodiazepines with neuroleptic activity.Journal of medicinal chemistry, , Volume: 32, Issue:10, 1989