Page last updated: 2024-08-07 16:29:56
Gastrin/cholecystokinin type B receptor
A cholecystokinin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32239]
Synonyms
CCK-B receptor;
CCK-BR;
Cholecystokinin-2 receptor;
CCK2-R
Research
Bioassay Publications (48)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 24 (50.00) | 18.2507 |
| 2000's | 16 (33.33) | 29.6817 |
| 2010's | 6 (12.50) | 24.3611 |
| 2020's | 2 (4.17) | 2.80 |
Compounds (26)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 5-methoxytryptamine | Homo sapiens (human) | Ki | 0.3020 | 1 | 1 |
| indopan | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 5-methoxy-alpha-methyltryptamine | Homo sapiens (human) | Ki | 0.3450 | 1 | 1 |
| spiroglumide | Homo sapiens (human) | IC50 | 1.3115 | 2 | 2 |
| Pyrrolidine-1-carbonitrile | Homo sapiens (human) | IC50 | 4.0000 | 1 | 2 |
| ci 988 | Homo sapiens (human) | IC50 | 0.0001 | 1 | 1 |
| ci 988 | Homo sapiens (human) | Ki | 0.0009 | 3 | 3 |
| l 740093 | Homo sapiens (human) | IC50 | 0.0001 | 1 | 1 |
| cholecystokinin 9 | Homo sapiens (human) | IC50 | 3.6880 | 1 | 1 |
| devazepide | Homo sapiens (human) | IC50 | 0.2450 | 1 | 1 |
| devazepide | Homo sapiens (human) | Ki | 0.0560 | 3 | 3 |
| tetragastrin | Homo sapiens (human) | Ki | 0.0172 | 3 | 4 |
| cholecystokinin (26-33) | Homo sapiens (human) | IC50 | 0.0269 | 1 | 1 |
| cholecystokinin (27-33), tert-butyloxycarbonyl-nle(28,31)- | Homo sapiens (human) | IC50 | 0.0002 | 2 | 2 |
| 2-(2-(5-bromo-1h-indol-3-yl)ethyl)-3-(1-methylethoxyphenyl)-4-(3h)-quinazolinone | Homo sapiens (human) | IC50 | 0.1205 | 2 | 2 |
| l 365260 | Homo sapiens (human) | IC50 | 0.0079 | 11 | 11 |
| l 365260 | Homo sapiens (human) | Ki | 0.0077 | 6 | 6 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Homo sapiens (human) | Ki | 0.0110 | 1 | 1 |
| sincalide | Homo sapiens (human) | IC50 | 0.0010 | 12 | 12 |
| sincalide | Homo sapiens (human) | Ki | 0.0005 | 3 | 4 |
| pentagastrin | Homo sapiens (human) | IC50 | 0.0010 | 1 | 1 |
| yf 476 | Homo sapiens (human) | Ki | 0.0001 | 3 | 3 |
| l 365260 | Homo sapiens (human) | IC50 | 0.2800 | 1 | 1 |
| mart-1 antigen | Homo sapiens (human) | IC50 | 0.2624 | 1 | 1 |
| 4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| naluzotan | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| butyloxycarbonyl-tryptophyl-methionyl-aspartyl-phenylalaninamide | Homo sapiens (human) | IC50 | 0.0250 | 3 | 3 |
| butyloxycarbonyl-tryptophyl-methionyl-aspartyl-phenylalaninamide | Homo sapiens (human) | Ki | 0.0420 | 1 | 1 |
| gastrin 17 | Homo sapiens (human) | IC50 | 0.0041 | 1 | 1 |
| nitd 609 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| enkephalin, d-penicillamine (2,5)- | Homo sapiens (human) | Kd | 0.0005 | 1 | 1 |
| cholecystokinin 9 | Homo sapiens (human) | EC50 | 0.0015 | 1 | 1 |
| tetragastrin | Homo sapiens (human) | Kd | 0.0217 | 1 | 1 |
| cholecystokinin (26-33) | Homo sapiens (human) | EC50 | 0.0270 | 1 | 1 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Homo sapiens (human) | EC50 | 0.0027 | 1 | 1 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Homo sapiens (human) | Kd | 0.0008 | 1 | 1 |
| sincalide | Homo sapiens (human) | EC50 | 0.0091 | 5 | 6 |
| sincalide | Homo sapiens (human) | Kd | 0.0016 | 2 | 2 |
| pentagastrin | Homo sapiens (human) | EC50 | 0.0028 | 1 | 1 |
| butyloxycarbonyl-tryptophyl-methionyl-aspartyl-phenylalaninamide | Homo sapiens (human) | EC50 | 0.0130 | 1 | 1 |
| gastrin 17 | Homo sapiens (human) | EC50 | 0.0005 | 1 | 1 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| cholecystokinin receptor activity | molecular function | Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. [GOC:signaling, PMID:9835394] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| gastrin receptor activity | molecular function | Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. [GOC:ai, GOC:signaling] |
| peptide hormone binding | molecular function | Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732] |
| type B gastrin/cholecystokinin receptor binding | molecular function | Binding to a type B gastrin/cholecystokinin receptor. [GOC:mah, GOC:nln] |
| 1-phosphatidylinositol-3-kinase regulator activity | molecular function | Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. [GOC:ai] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| gastric acid secretion | biological process | The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. [GOC:hjd] |
| cell surface receptor signaling pathway | biological process | The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling] |
| phospholipase C-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| positive regulation of cytosolic calcium ion concentration | biological process | Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai] |
| positive regulation of cell population proliferation | biological process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
| cholecystokinin signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:11181948] |
| pH reduction | biological process | Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. [GOC:go_curators] |
| digestive tract development | biological process | The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. [GOC:go_curators] |
| gland development | biological process | The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. [GOC:jid] |