Page last updated: 2024-10-19

melatonin and Necrosis

melatonin has been researched along with Necrosis in 43 studies

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" The aim of this study is to investigate whether iron overload causes the apoptosis and necrosis of bone marrow mesenchymal stem cells (BMSCs) and melatonin may prevent its toxicity."7.85Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin. ( Bao, Z; Cai, B; Ding, F; Du, Z; Feng, C; Gong, R; Han, Z; Hua, B; Huang, Q; Idiiatullina, E; Li, Y; Liu, T; Ma, W; Pavlov, V; Wang, X; Yan, G; Yang, F; Yang, L; Yu, Y; Yuan, Y; Zhang, L, 2017)
"In this study, chronic pain was induced by spared nerve injury model (SNI) for 4 weeks."5.48Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis. ( Li, C; Liu, M; Ma, H; Mu, N; Shi, Z; Wang, Y; Yang, J; Yang, Z; Yin, Y; Yu, L, 2018)
"Necrosis was evident in the DXR-treated group and some slides showed necrosis involving the fascia."5.36Melatonin ameliorates doxorubicin-induced skin necrosis in rats. ( Citak, EC; Karslioglu, Y; Kesik, V; Kismet, E; Koseoglu, V; Kurt, B; Tunc, T, 2010)
"The melatonin-treated rats showed markedly fewer apoptotic (TUNEL positive) cells and DNA fragmentation than did the I/R rats."5.35Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia/reperfusion injury in rat liver. ( Kim, SH; Lee, SM, 2008)
"Melatonin was intraperitoneally administered before or/and after IR injury."5.33Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. ( Briceño, J; Collado, JA; Cruz, A; Montilla, P; Muñoz-Casares, FC; Muñoz-Castañeda, JR; Muntané, J; Ortega, R; Padillo, FJ; Pera, C; Túnez, I, 2006)
" Flap necrosis rates and melatonin, oxidant, and antioxidant factors were studied."4.31Time-related variations in viability of random pattern skin flaps: An experimental study in rats. ( Aydin, OE; Ceylan, E; Cicek, K; Demir, N; Pehlevan, A; Tuzcu, A, 2023)
" The aim of this study is to investigate whether iron overload causes the apoptosis and necrosis of bone marrow mesenchymal stem cells (BMSCs) and melatonin may prevent its toxicity."3.85Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin. ( Bao, Z; Cai, B; Ding, F; Du, Z; Feng, C; Gong, R; Han, Z; Hua, B; Huang, Q; Idiiatullina, E; Li, Y; Liu, T; Ma, W; Pavlov, V; Wang, X; Yan, G; Yang, F; Yang, L; Yu, Y; Yuan, Y; Zhang, L, 2017)
" Based on this background, the present study evaluated the protective efficacy of melatonin in Echis carinatus (EC) venom-induced tissue necrosis, oxidative stress, and organ toxicity."3.80Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress. ( Girish, KS; Hemshekhar, M; Katkar, GD; Kemparaju, K; Rangappa, KS; Santhosh, MS; Sharma, DR; Sundaram, MS; Sunitha, K, 2014)
" We examined the effects of the antioxidant action of melatonin against necrosis-inducing DNA damage in hepatocytes of streptozotocin (STZ)-induced diabetic rats."3.80Hepatoprotective effects of melatonin against pronecrotic cellular events in streptozotocin-induced diabetic rats. ( Bogojević, D; Grigorov, I; Ivanović-Matić, S; Jovanović, S; Martinović, V; Petrović, A; Poznanović, G; Zolotarevski, L, 2014)
" Myocyte necrosis and fibrosis were diminished with melatonin while vasculitis was prevented."3.80Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model. ( Erkal, HŞ; Gürses, I; Özeren, M; Serin, M; Yücel, N, 2014)
" Melatonin reduces the apoptosis and necrosis in liver by inhibiting the activity of NF-kappaB and decreasing the expression of TNF-alpha."3.74[Mechanism of liver injury in severe acute pancreatitis rats and role of melatonin]. ( Fang, PP; Jia, GB; Ni, Y; Sun, XC; Wu, JS; Wu, XL; Zhang, RZ, 2008)
"Although both melatonin and oxytetracycline were found to be effective in autologous intraperitoneal pelvic ovary transplantation, melatonin is more effective against both the ovarian necrosis and tissue MDA level in rats."3.72Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats. ( Ayar, A; Celik, H; Kilic, N; Sapmaz, E; Sapmaz, T; Yasar, MA, 2003)
" On application of alloxan, this effect is caused by beta-cell necrosis and can be prevented by administration of melatonin, while in contrast, XO/HX did not lead to long-term morphological changes in the majority of the cells."3.70Influence of melatonin on free radical-induced changes in rat pancreatic beta-cells in vitro. ( Blume, R; Brömme, HJ; Ebelt, H; Mörke, W; Peschke, D; Peschke, E, 2000)
"Sepsis is one of the main causes of death among critically ill patients."2.55Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. ( Prauchner, CA, 2017)
"The features of apoptotic dose responses typically have been evaluated over a broad dose-response continuum to differentiate apoptotic and necrotic responses."2.41Apoptosis: biphasic dose responses. ( Calabrese, EJ, 2001)
"In this study, chronic pain was induced by spared nerve injury model (SNI) for 4 weeks."1.48Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis. ( Li, C; Liu, M; Ma, H; Mu, N; Shi, Z; Wang, Y; Yang, J; Yang, Z; Yin, Y; Yu, L, 2018)
"Our findings suggest MLT may prevent liver fibrosis by inhibiting necroptosis-associated inflammatory signaling."1.42Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis. ( Choi, HS; Kang, JW; Lee, SM, 2015)
"Melatonin (Mel) has a very potent antioxidant activity, depending mainly on its capacity to act as an electron donor."1.40The effect of melatonin on a dorsal skin flap model. ( Akdemır, O; Ates, U; Bılkay, U; Demırel Sezer, E; Kerem, H; Songur, E; Sozmen, E; Turgut, M; Uyanıkgıl, Y, 2014)
"Melatonin has a dose dependent protective effect on the structural alterations of proximal tubules of the kidney induced by gentamicin."1.40A histological study of the effect of exogenous melatonin on gentamicin induced structural alterations of proximal tubules in rats. ( Ćosović, E; Kapić, D; Mornjaković, Z; Šahinović, M, 2014)
"Melatonin was proposed for use in periodontitis and peri-implantitis therapy due to its bone-supportive effects."1.40Melatonin as a candidate therapeutic drug for protecting bone cells from chlorhexidine-induced damage. ( Abouassi, T; Hellwig, E; Proksch, S; Ratka-Krüger, P; Strobel, SL; Tomakidi, P; Vach, K, 2014)
"Necrosis was evident in the DXR-treated group and some slides showed necrosis involving the fascia."1.36Melatonin ameliorates doxorubicin-induced skin necrosis in rats. ( Citak, EC; Karslioglu, Y; Kesik, V; Kismet, E; Koseoglu, V; Kurt, B; Tunc, T, 2010)
"Melatonin treatment significantly improves the functional recovery of Langerdoff hearts on reperfusion, reduces the infarct size, and decreases necrotic damage as shown by the reduced release of lactate dehydrogenase."1.35Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. ( Colantuono, G; Di Venosa, N; Fiore, T; Moro, N; Paradies, G; Petrosillo, G; Ruggiero, FM; Tiravanti, E, 2009)
"The melatonin-treated rats showed markedly fewer apoptotic (TUNEL positive) cells and DNA fragmentation than did the I/R rats."1.35Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia/reperfusion injury in rat liver. ( Kim, SH; Lee, SM, 2008)
"Melatonin was found to be superior to octreotide with respect to the prevention of congestion, edema, axonal degeneration and necrosis."1.35Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury. ( Erol, FS; Ilhan, N; Kaplan, M; Ozercan, I; Tiftikci, M; Topsakal, C; Yakar, H, 2008)
"Melatonin was intraperitoneally administered before or/and after IR injury."1.33Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. ( Briceño, J; Collado, JA; Cruz, A; Montilla, P; Muñoz-Casares, FC; Muñoz-Castañeda, JR; Muntané, J; Ortega, R; Padillo, FJ; Pera, C; Túnez, I, 2006)
"Melatonin has marked antioxidant properties."1.33Therapeutic value of melatonin in an experimental model of liver injury and regeneration. ( Andreadou, I; Kostopanagiotou, G; Markantonis-Kyroudis, S; Papalabros, E; Sigala, F; Sigalas, K; Theocharis, S; Triantafyllou, A, 2006)
" Thus, melatonin and atenolol appear to have some adverse effects in CO intoxication on the myocardial cells."1.33Effect of melatonin and atenolol on carbon monoxide cardiotoxicity: an experimental study in rats. ( Celbiş, O; Mizrak, B; Olmez, E; Parlakpinar, H, 2006)
"Melatonin treatment, 30 minutes preceding 2-NP, reduced the increase in LI (44."1.31Inhibition of 2-nitropropane-induced cellular proliferation, DNA synthesis and histopathological changes by melatonin. ( El-Sokkary, GH, 2002)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.33)18.2507
2000's22 (51.16)29.6817
2010's18 (41.86)24.3611
2020's2 (4.65)2.80

Authors

AuthorsStudies
Aras, S1
Tanzer, IHO1
Karaçavuş, S1
Sayir, N1
Erdem, E1
Hacımustafaoğlu, F1
Erdoğan, CE1
Sapmaz, T2
İkizceli, T1
Pençe, HH1
Baydili, KN1
Katmer, T1
Aydin, OE1
Cicek, K1
Ceylan, E1
Tuzcu, A1
Pehlevan, A1
Demir, N1
Yang, F1
Li, Y1
Yan, G1
Liu, T1
Feng, C1
Gong, R1
Yuan, Y1
Ding, F1
Zhang, L1
Idiiatullina, E1
Pavlov, V1
Han, Z1
Ma, W1
Huang, Q1
Yu, Y1
Bao, Z1
Wang, X1
Hua, B1
Du, Z2
Cai, B1
Yang, L1
Esrefoglu, M1
Cetin, A1
Taslidere, E1
Elbe, H1
Ates, B1
Tok, OE1
Aydin, MS1
Yang, Z1
Li, C1
Wang, Y1
Yang, J1
Yin, Y1
Liu, M1
Shi, Z1
Mu, N1
Yu, L1
Ma, H1
Kerem, H1
Akdemır, O1
Ates, U1
Uyanıkgıl, Y1
Demırel Sezer, E1
Bılkay, U1
Turgut, M1
Sozmen, E1
Songur, E1
Kontek, R1
Jakubczak, M1
Matlawska-Wasowska, K1
Katkar, GD1
Sundaram, MS1
Hemshekhar, M1
Sharma, DR1
Santhosh, MS1
Sunitha, K1
Rangappa, KS1
Girish, KS1
Kemparaju, K1
Kapić, D1
Mornjaković, Z1
Ćosović, E1
Šahinović, M1
Grigorov, I1
Bogojević, D1
Jovanović, S1
Petrović, A1
Ivanović-Matić, S1
Zolotarevski, L1
Poznanović, G1
Martinović, V1
Proksch, S1
Strobel, SL1
Vach, K1
Abouassi, T1
Tomakidi, P1
Ratka-Krüger, P1
Hellwig, E1
Gürses, I1
Özeren, M1
Serin, M1
Yücel, N1
Erkal, HŞ1
Wang, F1
Zhou, H1
Chen, X1
Zhu, F1
Wang, Z1
Zhang, Y1
Lin, L1
Qian, M1
Zhang, X1
Li, X1
Hao, A1
Choi, HS1
Kang, JW1
Lee, SM2
Prauchner, CA1
Ni, Y1
Wu, JS1
Fang, PP1
Wu, XL1
Sun, XC1
Jia, GB1
Zhang, RZ1
Petrosillo, G1
Colantuono, G1
Moro, N1
Ruggiero, FM1
Tiravanti, E1
Di Venosa, N1
Fiore, T1
Paradies, G1
Kesik, V1
Kurt, B1
Tunc, T1
Karslioglu, Y1
Citak, EC1
Kismet, E1
Koseoglu, V1
Langer, SW1
Patschan, D1
Hildebrandt, A1
Rinneburger, J1
Wessels, JT1
Patschan, S1
Becker, JU1
Henze, E1
Krüger, A1
Müller, GA1
Malekinejad, H1
Rezabakhsh, A1
Rahmani, F1
Hobbenaghi, R1
Xu, C1
Wu, A1
Zhu, H1
Fang, H1
Xu, L1
Ye, J1
Shen, J1
Czeczuga-Semeniuk, E1
Wołczyński, S1
Anchim, T1
Dziecioł, J1
Dabrowska, M1
Pietruczuk, M1
El-Sokkary, GH1
Dziegiel, P1
Surowiak, P1
Rabczyński, J1
Zabel, M1
Kunduzova, OR1
Escourrou, G1
Seguelas, MH1
Delagrange, P1
De La Farge, F1
Cambon, C1
Parini, A1
Sapmaz, E1
Ayar, A1
Celik, H1
Kilic, N1
Yasar, MA1
Gurlek, A1
Aydogan, H1
Parlakpinar, H3
Bay-Karabulut, A1
Celik, M1
Sezgin, N1
Acet, A2
Rodríguez-Reynoso, S1
Leal, C1
Portilla-de Buen, E1
Castillo, JC1
Ramos-Solano, F1
Kavakli, A1
Sahna, E1
Yahsi, S1
Ogeturk, M1
Maharaj, DS1
Maharaj, H1
Daya, S1
Glass, BD1
Muñoz-Casares, FC1
Padillo, FJ1
Briceño, J1
Collado, JA1
Muñoz-Castañeda, JR1
Ortega, R1
Cruz, A1
Túnez, I1
Montilla, P1
Pera, C1
Muntané, J1
Sigala, F1
Theocharis, S1
Sigalas, K1
Markantonis-Kyroudis, S1
Papalabros, E1
Triantafyllou, A1
Kostopanagiotou, G1
Andreadou, I1
Mizrak, B1
Celbiş, O1
Olmez, E1
Noyan, T1
Kömüroğlu, U1
Bayram, I1
Sekeroğlu, MR1
Ozturk, F1
Ozturk, IC1
Batcioglu, K1
Vardi, N1
Kim, SH1
Erol, FS1
Kaplan, M1
Tiftikci, M1
Yakar, H1
Ozercan, I1
Ilhan, N1
Topsakal, C1
Woodgate, A1
MacGibbon, G1
Walton, M1
Dragunow, M1
Ebelt, H1
Peschke, D1
Brömme, HJ1
Mörke, W1
Blume, R1
Peschke, E1
Harms, C1
Lautenschlager, M1
Bergk, A1
Freyer, D1
Weih, M1
Dirnagl, U1
Weber, JR1
Hörtnagl, H1
Kölsch, H1
Ludwig, M1
Lütjohann, D1
Rao, ML1
Calabrese, EJ1

Reviews

2 reviews available for melatonin and Necrosis

ArticleYear
Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.
    Burns : journal of the International Society for Burn Injuries, 2017, Volume: 43, Issue:3

    Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Humans; Melatonin; Mitochondria; Multiple

2017
Apoptosis: biphasic dose responses.
    Critical reviews in toxicology, 2001, Volume: 31, Issue:4-5

    Topics: Animals; Antioxidants; Apoptosis; Cycloheximide; Dementia; Dimethylformamide; Dose-Response Relation

2001

Other Studies

41 other studies available for melatonin and Necrosis

ArticleYear
Effect of melatonin on low and high dose radiotherapy induced thyroid injury.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2023, Volume: 98, Issue:5

    Topics: Animals; Female; Melatonin; Necrosis; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted;

2023
Time-related variations in viability of random pattern skin flaps: An experimental study in rats.
    Chronobiology international, 2023, Oct-03, Volume: 40, Issue:10

    Topics: Animals; Antioxidants; Circadian Rhythm; Melatonin; Necrosis; Postoperative Complications; Rats; Ski

2023
Inhibition of iron overload-induced apoptosis and necrosis of bone marrow mesenchymal stem cells by melatonin.
    Oncotarget, 2017, May-09, Volume: 8, Issue:19

    Topics: Animals; Apoptosis; Bone Marrow Cells; Caspase 3; Cell Survival; Disease Models, Animal; Ferric Comp

2017
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
    Bratislavske lekarske listy, 2017, Volume: 118, Issue:6

    Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi

2017
Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis.
    Journal of molecular and cellular cardiology, 2018, Volume: 125

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chronic Pain; Immunohistochemistry; Mal

2018
The effect of melatonin on a dorsal skin flap model.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2014, Volume: 27, Issue:2

    Topics: Animals; Antioxidants; Catalase; Epithelium; Female; Malondialdehyde; Melatonin; Models, Animal; Nec

2014
The antioxidants, vitamin A and E but not vitamin C and melatonin enhance the proapoptotic effects of irinotecan in cancer cells in vitro.
    Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Ascorbic Acid; Camptothecin; Cell Line,

2014
Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress.
    Journal of pineal research, 2014, Volume: 56, Issue:3

    Topics: Animals; Free Radicals; Hemorrhage; Inflammation Mediators; Kidney; Liver; Melatonin; Mice; Muscle,

2014
A histological study of the effect of exogenous melatonin on gentamicin induced structural alterations of proximal tubules in rats.
    Bosnian journal of basic medical sciences, 2014, Volume: 14, Issue:1

    Topics: Animals; Antioxidants; Cytoplasm; Dose-Response Relationship, Drug; Gentamicins; Injections, Intrape

2014
Hepatoprotective effects of melatonin against pronecrotic cellular events in streptozotocin-induced diabetic rats.
    Journal of physiology and biochemistry, 2014, Volume: 70, Issue:2

    Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Male; Melatonin; Necrosis; Oxidative St

2014
Melatonin as a candidate therapeutic drug for protecting bone cells from chlorhexidine-induced damage.
    Journal of periodontology, 2014, Volume: 85, Issue:12

    Topics: 3T3 Cells; Animals; Anti-Infective Agents, Local; Antioxidants; Apoptosis; Cell Count; Cell Death; C

2014
Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model.
    Pathology, research and practice, 2014, Volume: 210, Issue:12

    Topics: Animals; Cardiomyopathies; Coronary Artery Disease; Coronary Vessels; Cytoprotection; Fibrosis; Male

2014
Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro.
    European journal of pharmacology, 2015, Feb-05, Volume: 748

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Hypoxia; Cell Survival; Cellular Mic

2015
Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis.
    Translational research : the journal of laboratory and clinical medicine, 2015, Volume: 166, Issue:3

    Topics: Animals; Apoptosis; Carbon Tetrachloride; Hepatocytes; HMGB1 Protein; Interleukin-1alpha; Interleuki

2015
[Mechanism of liver injury in severe acute pancreatitis rats and role of melatonin].
    Zhonghua yi xue za zhi, 2008, Nov-04, Volume: 88, Issue:40

    Topics: Animals; Apoptosis; Liver; Male; Melatonin; Necrosis; NF-kappa B; Pancreatitis, Acute Necrotizing; R

2008
Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:4

    Topics: Animals; Antioxidants; Calcium; Cardiolipins; Cardiovascular Agents; Cyclosporine; Cytochromes c; He

2009
Melatonin ameliorates doxorubicin-induced skin necrosis in rats.
    Annals of plastic surgery, 2010, Volume: 65, Issue:2

    Topics: Animals; Dimethyl Sulfoxide; Doxorubicin; Glutathione Peroxidase; Male; Malondialdehyde; Melatonin;

2010
RE: Kesik et al: melatonin ameliorates doxorubicin-induced skin necrosis in rats.
    Annals of plastic surgery, 2010, Volume: 65, Issue:5

    Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Doxorubicin; Melatonin; Necrosis; Rats; Sensiti

2010
The hormone melatonin stimulates renoprotective effects of "early outgrowth" endothelial progenitor cells in acute ischemic kidney injury.
    American journal of physiology. Renal physiology, 2012, May-15, Volume: 302, Issue:10

    Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Cell Movement; Cells, Cultured; Endothelial C

2012
Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, May-15, Volume: 19, Issue:7

    Topics: Animals; Antioxidants; Blood Glucose; Cytochrome P-450 CYP3A; Diabetes Mellitus, Experimental; Drug

2012
Melatonin is involved in the apoptosis and necrosis of pancreatic cancer cell line SW-1990 via modulating of Bcl-2/Bax balance.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2013, Volume: 67, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Cell

2013
Effect of melatonin and all-trans retinoic acid on the proliferation and induction of the apoptotic pathway in the culture of human breast cancer cell line MCF-7.
    Polish journal of pathology : official journal of the Polish Society of Pathologists, 2002, Volume: 53, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Count; Cell Division; Dose-Response Relatio

2002
Inhibition of 2-nitropropane-induced cellular proliferation, DNA synthesis and histopathological changes by melatonin.
    Neuro endocrinology letters, 2002, Volume: 23, Issue:4

    Topics: Animals; Anticonvulsants; Cell Division; DNA; Drug Interactions; Hepatocytes; Male; Melatonin; Mutag

2002
Effect of melatonin on cytotoxic effects of daunorubicin on myocardium and on transplantable Morris hepatoma in rats.
    Polish journal of pathology : official journal of the Polish Society of Pathologists, 2002, Volume: 53, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Daunorubicin; Heart; In Situ Nick-End

2002
Prevention of apoptotic and necrotic cell death, caspase-3 activation, and renal dysfunction by melatonin after ischemia/reperfusion.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:8

    Topics: Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Caspase 3; Caspases; Creatinine; Enzyme Activ

2003
Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats.
    Neuro endocrinology letters, 2003, Volume: 24, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Antioxidants; Female; Graft Survival; Malondialdehyde; Melatonin; Ne

2003
Protective effect of melatonin on random pattern skin flap necrosis in pinealectomized rat.
    Journal of pineal research, 2004, Volume: 36, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Female; Glutathione; Glutathione Peroxidase; Malondialdeh

2004
Melatonin ameliorates renal ischemia/reperfusion injury.
    The Journal of surgical research, 2004, Volume: 116, Issue:2

    Topics: Animals; Creatinine; Glutathione; Kidney; Lipid Peroxidation; Male; Melatonin; Necrosis; Nitric Oxid

2004
The effects of melatonin on focal cerebral ischemia-reperfusion model.
    Saudi medical journal, 2004, Volume: 25, Issue:11

    Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Disease Models, Animal; Infarction, Middle

2004
Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity.
    Journal of neurochemistry, 2006, Volume: 96, Issue:1

    Topics: Animals; Antioxidants; Hippocampus; Iron; Lipid Peroxidation; Male; Melatonin; Necrosis; Neurotoxici

2006
Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas.
    Journal of pineal research, 2006, Volume: 40, Issue:3

    Topics: Amylases; Animals; Apoptosis; Caspase 3; Caspases; Catalase; DNA Fragmentation; Glutathione; Glutath

2006
Therapeutic value of melatonin in an experimental model of liver injury and regeneration.
    Journal of pineal research, 2006, Volume: 40, Issue:3

    Topics: Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisonin

2006
Effect of melatonin and atenolol on carbon monoxide cardiotoxicity: an experimental study in rats.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Carbon Monoxide Poisoning; Carboxyhemoglobin; Female

2006
Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice.
    Cell biology and toxicology, 2006, Volume: 22, Issue:6

    Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver In

2006
The effect of melatonin on 7,12-dimethyl-benz[a]anthracene injury in comparison with vitamin E + selenium in mouse kidneys.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:4

    Topics: Animals; Antioxidants; Benz(a)Anthracenes; Catalase; Female; Glutathione Peroxidase; Kidney; Kidney

2006
Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia/reperfusion injury in rat liver.
    Journal of pineal research, 2008, Volume: 44, Issue:2

    Topics: Animals; Apoptosis; Liver; Male; Melatonin; Necrosis; Oxidation-Reduction; Rats; Reperfusion Injury

2008
Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2008, Volume: 15, Issue:7

    Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration

2008
The toxicity of 6-hydroxydopamine on PC12 and P19 cells.
    Brain research. Molecular brain research, 1999, May-21, Volume: 69, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Aurintricarboxylic Acid; Biological Transport; Bisbenzimi

1999
Influence of melatonin on free radical-induced changes in rat pancreatic beta-cells in vitro.
    Journal of pineal research, 2000, Volume: 28, Issue:2

    Topics: Alloxan; Animals; Electron Spin Resonance Spectroscopy; Female; Free Radical Scavengers; Free Radica

2000
Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:12

    Topics: Animals; Antioxidants; Apoptosis; Aziridines; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cu

2000
Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta.
    Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:4

    Topics: Antioxidants; Ascorbic Acid; Brain; Caspase 3; Caspases; Estradiol; Free Radicals; Humans; Hydroxych

2001