Proteins > Vascular endothelial growth factor receptor 3
Page last updated: 2024-08-07 16:35:03

Vascular endothelial growth factor receptor 3

A vascular endothelial growth factor receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35916]

Synonyms

VEGFR-3;
EC 2.7.10.1;
Fms-like tyrosine kinase 4;
FLT-4;
Tyrosine-protein kinase receptor FLT4

Research

Bioassay Publications (91)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's37 (40.66)29.6817
2010's45 (49.45)24.3611
2020's9 (9.89)2.80

Compounds (122)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pd 173074Homo sapiens (human)IC500.190011
papaverineHomo sapiens (human)IC5024.330011
galantamineHomo sapiens (human)IC500.590011
staurosporineHomo sapiens (human)IC500.014699
ptk 787Homo sapiens (human)IC500.195011
vatalanibHomo sapiens (human)IC500.147522
birb 796Homo sapiens (human)IC500.270011
Serotonin hydrochlorideHomo sapiens (human)IC5050.000011
erlotinibHomo sapiens (human)IC500.250011
sorafenibHomo sapiens (human)IC500.019155
papaverinolHomo sapiens (human)IC5010.730011
zd 6474Homo sapiens (human)IC500.146466
ellagic acidHomo sapiens (human)IC501.540011
cb676475Homo sapiens (human)IC501.000011
semaxinibHomo sapiens (human)IC500.275022
su 11248Homo sapiens (human)IC500.008911
su 11248Homo sapiens (human)Ki0.017011
n,n'-dimethyl-n,n'-bis(mercaptoacetyl)hydrazineHomo sapiens (human)IC500.032011
6-(4-methoxyphenyl)-3-(3-thiophenyl)pyrazolo[1,5-a]pyrimidineHomo sapiens (human)IC500.387022
2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-oneHomo sapiens (human)IC500.690011
2-((4-pyridyl)methyl)amino-n-(3-(trifluoromethyl)phenyl)benzamideHomo sapiens (human)IC500.018022
axitinibHomo sapiens (human)IC500.000122
gdp 366Homo sapiens (human)IC500.013022
krn 633Homo sapiens (human)IC500.125011
jnj 10198409Homo sapiens (human)IC503.100011
telatinibHomo sapiens (human)IC500.004022
lenvatinibHomo sapiens (human)IC500.005244
gw843682xHomo sapiens (human)IC500.092011
tivozanibHomo sapiens (human)IC500.001722
3,9-bis((ethylthio)methyl)-k-252aHomo sapiens (human)IC500.039011
cediranibHomo sapiens (human)IC500.003022
pazopanibHomo sapiens (human)IC500.046844
sotrastaurinHomo sapiens (human)IC504.600011
saracatinibHomo sapiens (human)IC5010.000011
l 783277Homo sapiens (human)GI500.050011
l 783277Homo sapiens (human)IC500.000922
regorafenibHomo sapiens (human)IC500.046011
danusertibHomo sapiens (human)IC500.161011
abt 869Homo sapiens (human)IC500.130933
azd2932Homo sapiens (human)IC500.008011
chir-265Homo sapiens (human)IC500.020011
motesanibHomo sapiens (human)IC500.9215313
pha 767491Homo sapiens (human)IC5010.000011
jnj-26483327Homo sapiens (human)IC500.011011
pha 848125Homo sapiens (human)IC500.920011
tak 593Homo sapiens (human)IC500.001122
quizartinibHomo sapiens (human)IC504.900011
lucitanibHomo sapiens (human)IC500.010022
cabozantinibHomo sapiens (human)IC500.006011
entrectinibHomo sapiens (human)IC501.000011
gsk 1363089Homo sapiens (human)IC500.003055
mk 2461Homo sapiens (human)IC500.078011
pha 793887Homo sapiens (human)IC5010.000011
3-((4-(6-methylpyridin-2-yl)-5-(quinolin-6-yl)-1h-imidazol-2-yl)methyl)benzamideHomo sapiens (human)IC500.940011
gsk 1070916Homo sapiens (human)IC500.074021
nms p937Homo sapiens (human)IC5010.000011
glpg0634Homo sapiens (human)IC500.274021
cep-28122Homo sapiens (human)IC500.048011
cc-223Homo sapiens (human)IC500.651011
vx-970Homo sapiens (human)Ki0.008011
pf-543Homo sapiens (human)IC5010.000011
sar131675Homo sapiens (human)GI500.059011
sar131675Homo sapiens (human)IC500.001211
at 9283Homo sapiens (human)IC500.001011
chir 258Homo sapiens (human)IC500.004533
nintedanibHomo sapiens (human)IC500.011655
nms-e973Homo sapiens (human)IC500.010011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd10.000033
staurosporineHomo sapiens (human)Kd0.029033
gefitinibHomo sapiens (human)Kd10.000022
lestaurtinibHomo sapiens (human)Kd0.017022
vatalanibHomo sapiens (human)Kd0.283333
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd10.000022
birb 796Homo sapiens (human)Kd5.566733
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd3.800011
erlotinibHomo sapiens (human)Kd2.100022
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd0.063455
pd 173955Homo sapiens (human)Kd0.740011
s 1033Homo sapiens (human)Kd10.000011
bms 387032Homo sapiens (human)Kd10.000022
tandutinibHomo sapiens (human)Kd9.066733
vx-745Homo sapiens (human)Kd10.000022
dasatinibHomo sapiens (human)Kd10.000022
zd 6474Homo sapiens (human)Kd0.833333
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd10.000022
bosutinibHomo sapiens (human)Kd10.000011
su 11248Homo sapiens (human)Kd0.044055
jnj-7706621Homo sapiens (human)Kd1.100011
vx680Homo sapiens (human)Kd1.900022
ekb 569Homo sapiens (human)Kd10.000011
axitinibHomo sapiens (human)Kd0.170011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd0.670033
ki 20227Homo sapiens (human)Kd0.390011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd0.004311
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd0.027022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd0.050022
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd1.400011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.009111
brivanibHomo sapiens (human)Kd0.056011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd0.120022
kw 2449Homo sapiens (human)Kd1.300011
abt 869Homo sapiens (human)Kd0.016022
gw 2580Homo sapiens (human)Kd10.000022
crizotinibHomo sapiens (human)Kd10.000011
chir-265Homo sapiens (human)Kd2.000022
motesanibHomo sapiens (human)Kd0.009722
mln8054Homo sapiens (human)Kd3.100022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd6.450022
nvp-tae684Homo sapiens (human)Kd0.170011
fedratinibHomo sapiens (human)Kd2.000011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd10.000011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd0.041044
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd0.001511
chir 258Homo sapiens (human)Kd0.580022
nintedanibHomo sapiens (human)Kd0.095011
pp242Homo sapiens (human)Kd0.240011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
brivanibHomo sapiens (human)Activity0.040011

Enables

This protein enables 7 target(s):

TargetCategoryDefinition
transmembrane receptor protein tyrosine kinase activitymolecular functionCombining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [EC:2.7.10.1, GOC:mah]
vascular endothelial growth factor receptor activitymolecular functionCombining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:19909239]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
growth factor bindingmolecular functionBinding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. [GOC:curators]
protein phosphatase bindingmolecular functionBinding to a protein phosphatase. [GOC:jl]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
receptor complexcellular componentAny protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 29 target(s):

TargetCategoryDefinition
positive regulation of protein phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
positive regulation of endothelial cell proliferationbiological processAny process that activates or increases the rate or extent of endothelial cell proliferation. [GOC:add]
vasculature developmentbiological processThe process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. [GOC:dph, UBERON:0002409]
lymph vessel developmentbiological processThe process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. [GOC:dph, UBERON:0001473]
lymphangiogenesisbiological processLymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. [GOC:dph, PMID:11596157]
sprouting angiogenesisbiological processThe extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. [PMID:16391003, PMID:23031691]
respiratory system processbiological processA process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. [GOC:dph, GOC:mtg_cardio, GOC:tb]
cell surface receptor protein tyrosine kinase signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
positive regulation of vascular endothelial growth factor productionbiological processAny process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. [GOC:BHF, GOC:rl]
positive regulation of endothelial cell migrationbiological processAny process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:BHF, GOC:dph, GOC:tb]
peptidyl-tyrosine phosphorylationbiological processThe phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039]
cellular response to vascular endothelial growth factor stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, PMID:18440775]
vascular endothelial growth factor signaling pathwaybiological processThe series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, PMID:17470632]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of MAPK cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
positive regulation of JNK cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
protein autophosphorylationbiological processThe phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]
vascular endothelial growth factor receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
lung alveolus developmentbiological processThe process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. [GOC:mtg_lung, PMID:9751757]
blood vessel morphogenesisbiological processThe process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. [GOC:jid]
regulation of blood vessel remodelingbiological processAny process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of ERK1 and ERK2 cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
positive regulation of protein kinase C signalingbiological processAny process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. [GOC:dph, GOC:tb]
positive regulation of cell migrationbiological processAny process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
positive regulation of kinase activitybiological processAny process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]
multicellular organism developmentbiological processThe biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
regulation of MAPK cascadebiological processAny process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. [GOC:go_curators]
angiogenesisbiological processBlood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]