Proteins > Poly [ADP-ribose] polymerase 2

Page last updated: 2024-08-08 00:21:33

Poly [ADP-ribose] polymerase 2

A poly [ADP-ribose] polymerase 2 that is encoded in the genome of human. [PRO:DNx]

Synonyms

PARP-2;
hPARP-2;
EC 2.4.2.30;
ADP-ribosyltransferase diphtheria toxin-like 2;
ARTD2;
DNA ADP-ribosyltransferase PARP2;
2.4.2.-;
NAD(+) ADP-ribosyltransferase 2;
ADPRT-2;
Poly[ADP-ribose] synthase 2;
pADPRT-2;
P

Research

Bioassay Publications (43)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (6.98)	29.6817
2010's	24 (55.81)	24.3611
2020's	16 (37.21)	2.80

Compounds (14)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pj-34	Homo sapiens (human)	IC50	0.1687	3	5
4-Methoxybenzamide	Homo sapiens (human)	IC50	77.0000	1	1
amentoflavone	Homo sapiens (human)	IC50	10.3000	2	2
rucaparib	Homo sapiens (human)	IC50	0.0497	9	11
rucaparib	Homo sapiens (human)	Ki	0.0007	1	1
veliparib	Homo sapiens (human)	IC50	0.0688	7	9
veliparib	Homo sapiens (human)	Ki	0.0113	2	2
olaparib	Homo sapiens (human)	IC50	0.1866	22	24
niraparib	Homo sapiens (human)	IC50	0.2306	7	8
niraparib	Homo sapiens (human)	Ki	0.0040	1	1
iwr-1 endo	Homo sapiens (human)	IC50	53.4900	5	5
nms-p118	Homo sapiens (human)	IC50	6.6000	1	1
g007-lk	Homo sapiens (human)	IC50	100.0000	2	2
xav939	Homo sapiens (human)	IC50	0.5276	10	11
bmn 673	Homo sapiens (human)	IC50	0.0079	4	4
bmn 673	Homo sapiens (human)	Ki	0.0009	2	2
nvp-tnks656	Homo sapiens (human)	IC50	32.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rucaparib	Homo sapiens (human)	EC50	0.0047	1	1
rucaparib	Homo sapiens (human)	Kd	0.0260	1	1
veliparib	Homo sapiens (human)	EC50	0.0059	1	1
veliparib	Homo sapiens (human)	Kd	0.0084	2	2
olaparib	Homo sapiens (human)	EC50	0.0036	1	1
olaparib	Homo sapiens (human)	Kd	0.0004	3	3
niraparib	Homo sapiens (human)	EC50	0.0240	2	2
niraparib	Homo sapiens (human)	EC50	0.0040	2	2
niraparib	Homo sapiens (human)	Kd	0.0780	1	1
nms-p118	Homo sapiens (human)	Kd	1.3945	2	2
bmn 673	Homo sapiens (human)	EC50	0.0025	2	2
bmn 673	Homo sapiens (human)	Kd	0.0033	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
niraparib	Homo sapiens (human)	EC90	0.2200	1	1
niraparib	Homo sapiens (human)	EC90	0.0450	1	1
niraparib	Homo sapiens (human)	IC90	0.0493	3	3

Enables

This protein enables 13 target(s):

Target	Category	Definition
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
damaged DNA binding	molecular function	Binding to damaged DNA. [GOC:jl]
NAD+ ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
nucleotidyltransferase activity	molecular function	Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]
nucleosome binding	molecular function	Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:mah]
poly-ADP-D-ribose binding	molecular function	Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. [GOC:mah, GOC:sart, PMID:20088964]
NAD DNA ADP-ribosyltransferase activity	molecular function	Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. [PMID:27471034, PMID:29361132, PMID:29520010]
NAD+-protein-serine ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. [PMID:32028527, PMID:33186521, RHEA:58232]
NAD+- protein-aspartate ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:54424]
NAD+-protein-glutamate ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:58224]
poly-ADP-D-ribose modification-dependent protein binding	molecular function	Binding to a protein upon poly-ADP-ribosylation of the target protein. [PMID:26673700]
NAD+-protein ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nucleolus	cellular component	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
site of DNA damage	cellular component	A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:pg]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
site of DNA damage	cellular component	A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:pg]
nucleolus	cellular component	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
DNA repair	biological process	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
base-excision repair	biological process	In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. [ISBN:0815316194]
DNA damage response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
DNA ADP-ribosylation	biological process	The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA. [PMID:11592983, PMID:27471034, PMID:29361132, PMID:29520010]
decidualization	biological process	The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. [ISBN:0721662544, PMID:11133685]
positive regulation of cell growth involved in cardiac muscle cell development	biological process	Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. [GOC:dph]
protein poly-ADP-ribosylation	biological process	The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]
protein auto-ADP-ribosylation	biological process	The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl]
response to oxygen-glucose deprivation	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. [GOC:sl, PMID:21525936]
extrinsic apoptotic signaling pathway	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]
hippocampal neuron apoptotic process	biological process	Any apoptotic process that occurs in a hippocampal neuron. [GOC:sl, PMID:18940801]
DNA repair-dependent chromatin remodeling	biological process	A chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions. [PMID:15528408, PMID:28053344, PMID:29095668, PMID:35689883]
double-strand break repair	biological process	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh]