A sodium- and chloride-dependent betaine transporter that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48065]
BGT-1;
Na(+)/Cl(-) betaine/GABA transporter;
Solute carrier family 6 member 12
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gamma-aminobutyric acid | Homo sapiens (human) | IC50 | 15.8771 | 30 | 56 |
| 2,3-diaminopropionic acid | Homo sapiens (human) | IC50 | 630.9570 | 1 | 1 |
| guvacine | Homo sapiens (human) | IC50 | 1,870.0000 | 1 | 1 |
| nipecotic acid | Homo sapiens (human) | IC50 | 2,370.0000 | 1 | 1 |
| tiagabine | Homo sapiens (human) | IC50 | 1,670.0000 | 1 | 1 |
| ci 966 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| n-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide | Homo sapiens (human) | IC50 | 29.7129 | 27 | 53 |
| nipecotic acid | Homo sapiens (human) | IC50 | 2,310.0000 | 1 | 1 |
| nipecotic acid, (s)-isomer | Homo sapiens (human) | IC50 | 6,410.0000 | 1 | 1 |
| 2-ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide | Homo sapiens (human) | IC50 | 180.9850 | 1 | 2 |
| nnc 05-2090 | Homo sapiens (human) | IC50 | 5.1000 | 2 | 2 |
| snap 5114 | Homo sapiens (human) | IC50 | 106.1635 | 4 | 4 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| gamma-aminobutyric acid:sodium:chloride symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). [PMID:7589472, PMID:7861179] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| monocarboxylic acid transmembrane transporter activity | molecular function | Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. [GOC:ai] |
| amino acid transmembrane transporter activity | molecular function | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| presynapse | cellular component | The part of a synapse that is part of the presynaptic cell. [GOC:dos] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cell projection | cellular component | A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| amino acid transmembrane transport | biological process | The process in which an amino acid is transported across a membrane. [GOC:dph, GOC:tb] |
| amino acid transport | biological process | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| monocarboxylic acid transport | biological process | The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| gamma-aminobutyric acid transport | biological process | The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732] |
| glycine betaine transport | biological process | The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah] |
| gamma-aminobutyric acid reuptake | biological process | The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |