iothalamate-meglumine and Necrosis

To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis.. Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was induced through retrograde injection of 5% sodium taurocholate (1 mL/kg weight) in the main pancreatic duct. After 3 hours, they were randomized to receive endovenous iodinized nonionic contrast medium (group 1), iodinized ionic contrast medium (group 2), gadoteric acid (group 3), and physiological serum at 0.9% (group 4). Six hours after induction of pancreatitis, these animals were reoperated. During surgery, pancreatic tissue flow through laser Doppler, hematometric values, biochemistry, and histopathology analysis by hematoxylin and eosin were done. Statistical analysis using Kruskal-Wallis, Fisher-Freeman-Halton, and parametric t tests was performed.. There was statistical significance when comparing tissue flow before and after induction of pancreatitis (P < 0.0001). Ionic and nonionic contrast media and gadoteric acid did not increase the grade of pancreatic necrosis (P > 0.05).. Ionic and nonionic contrast media and gadoteric acid did not produce adverse effects in the present model of acute necrotizing pancreatitis.

Topics: Animals; Contrast Media; Disease Models, Animal; Heterocyclic Compounds; Injections, Intravenous; Iohexol; Iothalamate Meglumine; Laser-Doppler Flowmetry; Necrosis; Organometallic Compounds; Osmolar Concentration; Pancreas; Pancreatitis, Acute Necrotizing; Rabbits; Regional Blood Flow; Taurocholic Acid; Time Factors

Topics: Acute Disease; Animals; Contrast Media; Iopamidol; Iothalamate Meglumine; Necrosis; Pancreatitis; Rats; Tomography, X-Ray Computed

Twenty-eight consecutive patients with a first attack of alcohol-induced pancreatitis were studied using contrast-enhanced CT. The findings on CT were then related to the course of the disease. The patients with acute hemorrhagic-necrotizing pancreatitis showed significantly lower enhancement values of the pancreatic parenchyma than those with milder forms of the disease. The next 20 patients with severe pancreatitis were scanned using a slightly modified procedure. The enhancement values were calculated and plotted on the graphs for the 2 former groups. Two categories of pancreatic enhancement were found: "low enhancement" and "high enhancement." In all 10 patients with "low-enhancement" values surgery revealed hemorrhagic-necrotizing pancreatitis. In the 10 patients with "high-enhancement" values conservative treatment was continued, and the clinical course was nonfulminant in all of them.

Topics: Acute Disease; Alcoholism; Hemorrhage; Humans; Iothalamate Meglumine; Necrosis; Pancreatitis; Radiographic Image Enhancement; Tomography, X-Ray Computed