P2Y purinoceptor 4

A P2Y purinoceptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51582]

Synonyms

P2Y4;
P2P;
Uridine nucleotide receptor;
UNR

Research

Bioassay Publications (17)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (47.06)	29.6817
2010's	9 (52.94)	24.3611
2020's	0 (0.00)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
acid blue 25	Homo sapiens (human)	IC50	17.8567	3	3

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid	Homo sapiens (human)	EC50	10.0000	1	1
suramin	Homo sapiens (human)	EC50	100.0000	1	1
uridine diphosphate	Homo sapiens (human)	EC50	14.0000	1	1
uridine triphosphate	Homo sapiens (human)	EC50	0.3758	15	15
diquafosol	Homo sapiens (human)	EC50	0.1300	2	2
phosphoribofuranosylbarbituric acid	Homo sapiens (human)	EC50	100.0000	1	1
uridine 5'-tetraphosphate	Homo sapiens (human)	EC50	5.9700	2	2
TTP	Homo sapiens (human)	EC50	3.9000	1	1
4-thiouridine triphosphate	Homo sapiens (human)	EC50	0.0230	2	2
5-bromouridine triphosphate	Homo sapiens (human)	EC50	6.7300	2	2
denufosol tetrasodium	Homo sapiens (human)	EC50	0.1400	1	1
denufosol tetrasodium	Homo sapiens (human)	EC50	0.8000	1	1
5-fluorouridine 5'-triphosphate	Homo sapiens (human)	EC50	0.6000	1	1
4-thiouridylic acid	Homo sapiens (human)	EC50	100.0000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
G protein-coupled purinergic nucleotide receptor activity	molecular function	Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, PMID:9755289]
G protein-coupled UTP receptor activity	molecular function	Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP. [GOC:mah]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
presynaptic active zone membrane	cellular component	The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. [PMID:12812759, PMID:12923177, PMID:3152289]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
transepithelial chloride transport	biological process	The directed movement of chloride ions from one side of an epithelium to the other. [GOC:mah]
G protein-coupled purinergic nucleotide receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, PMID:9755289]
cellular response to ATP	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah]
cellular response to prostaglandin E stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. [GOC:mah]
regulation of presynaptic cytosolic calcium ion concentration	biological process	Any process that regulates the concentration of calcium in the presynaptic cytosol. [GOC:dos]
regulation of synaptic vesicle exocytosis	biological process	Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]

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