Page last updated: 2024-08-07 15:37:09
Sex hormone-binding globulin
A sex hormone-binding globulin that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04278]
Synonyms
SHBG;
Sex steroid-binding protein;
SBP;
Testis-specific androgen-binding protein;
ABP;
Testosterone-estradiol-binding globulin;
TeBG;
Testosterone-estrogen-binding globulin
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (46)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.Journal of medicinal chemistry, , Apr-10, Volume: 51, Issue:7, 2008
A novel, nonsteroidal inhibitor of androgen binding to the rat androgen binding protein: diethyl [[[3-(2,6-dimethyl-4-pyridinyl)-4-fluorophenyl]amino]methylene] propanedioate.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| androgen binding | molecular function | Binding to an androgen, a male sex hormone. [GOC:jl] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| steroid binding | molecular function | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |