Page last updated: 2024-08-07 15:37:09
Sex hormone-binding globulin
A sex hormone-binding globulin that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04278]
Synonyms
SHBG;
Sex steroid-binding protein;
SBP;
Testis-specific androgen-binding protein;
ABP;
Testosterone-estradiol-binding globulin;
TeBG;
Testosterone-estrogen-binding globulin
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (46)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| dihydrotestosterone | Homo sapiens (human) | IC50 | 0.0038 | 1 | 1 |
| secoisolariciresinol | Homo sapiens (human) | IC50 | 230.0000 | 1 | 1 |
| matairesinol | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| 2,4,4'-trihydroxydeoxybenzoin | Homo sapiens (human) | IC50 | 13.6000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-nonylphenol | Homo sapiens (human) | Kd | 1.2023 | 1 | 1 |
| corticosterone | Homo sapiens (human) | Kd | 0.4571 | 1 | 1 |
| estriol | Homo sapiens (human) | Kd | 0.2344 | 1 | 1 |
| aldosterone | Homo sapiens (human) | Kd | 4.7863 | 1 | 1 |
| estrone | Homo sapiens (human) | Kd | 0.0066 | 1 | 1 |
| androsterone | Homo sapiens (human) | Kd | 0.0708 | 1 | 1 |
| etiocholanolone | Homo sapiens (human) | Kd | 0.7080 | 1 | 1 |
| dehydroepiandrosterone | Homo sapiens (human) | Kd | 0.0144 | 1 | 1 |
| 17-desoxyestradiol | Homo sapiens (human) | Kd | 0.0050 | 1 | 1 |
| ethinyl estradiol | Homo sapiens (human) | Kd | 0.1549 | 1 | 1 |
| methyltestosterone | Homo sapiens (human) | Kd | 0.0037 | 1 | 1 |
| androstenedione | Homo sapiens (human) | Kd | 0.0347 | 1 | 1 |
| desoxycorticosterone | Homo sapiens (human) | Kd | 0.0417 | 1 | 1 |
| norethindrone | Homo sapiens (human) | Kd | 0.0107 | 1 | 1 |
| 17-alpha-hydroxyprogesterone | Homo sapiens (human) | Kd | 0.1000 | 1 | 1 |
| medroxyprogesterone acetate | Homo sapiens (human) | Kd | 0.6310 | 1 | 1 |
| 4-tert-octylphenol | Homo sapiens (human) | Kd | 2.1380 | 1 | 1 |
| pregnenolone | Homo sapiens (human) | Kd | 0.0708 | 1 | 1 |
| nandrolone | Homo sapiens (human) | Kd | 0.5012 | 1 | 1 |
| mestanolone | Homo sapiens (human) | Kd | 0.0015 | 1 | 1 |
| androstenediol | Homo sapiens (human) | Kd | 0.0007 | 1 | 1 |
| dihydrotestosterone | Homo sapiens (human) | Kd | 0.0002 | 1 | 1 |
| mesterolone | Homo sapiens (human) | Kd | 0.0003 | 1 | 1 |
| 5 alpha-androstane-3 alpha,17 beta-diol | Homo sapiens (human) | Kd | 0.0008 | 1 | 1 |
| gestrinone | Homo sapiens (human) | Kd | 0.0078 | 1 | 1 |
| danazol | Homo sapiens (human) | Kd | 0.0063 | 1 | 1 |
| desogestrel | Homo sapiens (human) | Kd | 0.2512 | 1 | 1 |
| 16-hydroxytestosterone | Homo sapiens (human) | Kd | 0.0120 | 1 | 1 |
| 2-methoxyestradiol | Homo sapiens (human) | Kd | 0.0008 | 1 | 1 |
| 2-iodoestradiol | Homo sapiens (human) | Kd | 0.0005 | 1 | 1 |
| 17-alpha-hydroxypregnenolone | Homo sapiens (human) | Kd | 0.4365 | 1 | 1 |
| bolasterone | Homo sapiens (human) | Kd | 0.0017 | 1 | 1 |
| matairesinol | Homo sapiens (human) | Kd | 0.3090 | 1 | 1 |
| 4-androstene-3,17-diol | Homo sapiens (human) | Kd | 0.0010 | 1 | 1 |
| 3,4-divanillyltetrahydrofuran | Homo sapiens (human) | Kd | 0.3090 | 1 | 1 |
| estradiol 3-benzoate | Homo sapiens (human) | Kd | 1.1482 | 1 | 1 |
| cortisone | Homo sapiens (human) | Kd | 0.3715 | 1 | 1 |
| equilin | Homo sapiens (human) | Kd | 0.0031 | 1 | 1 |
| naringenin | Homo sapiens (human) | Kd | 14.5694 | 1 | 2 |
| cortodoxone | Homo sapiens (human) | Kd | 0.0363 | 1 | 1 |
| equilenin | Homo sapiens (human) | Kd | 0.0024 | 1 | 1 |
| genistein | Homo sapiens (human) | Kd | 39.8107 | 1 | 1 |
| ethisterone | Homo sapiens (human) | Kd | 0.0017 | 1 | 1 |
| etonogestrel | Homo sapiens (human) | Kd | 0.0059 | 1 | 1 |
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| androgen binding | molecular function | Binding to an androgen, a male sex hormone. [GOC:jl] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| steroid binding | molecular function | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |