Compounds > 3'-o-(4-benzoyl)benzoyladenosine 5'-triphosphate
Page last updated: 2024-09-24

3'-o-(4-benzoyl)benzoyladenosine 5'-triphosphate

Description

3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate: purinergic receptors agonist; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID115205
CHEMBL ID2407634
CHEBI ID34316
SCHEMBL ID3682844
MeSH IDM0104881

Synonyms (26)

Synonym
gtpl1757
[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-(hydroxy-phosphonooxyphosphoryl)oxyphosphoryl]oxymethyl]oxolan-3-yl] 4-(benzoyl)benzoate
3'-o-(4-benzoyl)benzoyl atp
bzatp
81790-82-1
3'-o-(4-benzoyl)benzoyladenosine 5'-triphosphate
adenosine 5'-(tetrahydrogen triphosphate), 3'-(4-benzoylbenzoate)
3'-o-(4-benzoylbenzoyl)atp
phenol, 4,4'-thiobis[3-dodecyl-
[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]oxolan-3-yl] 4-benzoylbenzoate
chebi:34316 ,
CHEMBL2407634
unii-4p5dxu1f8q
4p5dxu1f8q ,
cas_81790-82-1
bdbm86488
atp, bz
SCHEMBL3682844
[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxy-phosphoryl]oxymethyl]tetrahydrofuran-3-yl] 4-benzoylbenzoate
3'-o-(4-benzoylbenzoyl)adenosine 5'-triphosphate
E72651
Q27075614
(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy(phosphonooxy)phosphoryl)oxy)phosphoryl)oxy)methyl)tetrahydrofuran-3-yl 4-benzoylbenzoate
9-[3-o-(4-benzoylbenzoyl)-5-o-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-9h-purin-6-amine
DTXSID001002227
(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy(phosphonooxy)phosphoryl)oxy)phosphoryl)oxy)methyl)tetrahydrofuran-3-yl4-benzoylbenzoate

Drug Classes (1)

ClassDescription
purine ribonucleoside triphosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)Ki8.78000.52003.93508.1900AID1415777; AID1415784
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Rattus norvegicus (Norway rat)Ki20.50002.20005.90009.6000AID1415787
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
generation of precursor metabolites and energyEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
phosphate-containing compound metabolic processEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
immune responseEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
nucleoside triphosphate catabolic processEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
response to inorganic substanceEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
gene expressionEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
vesicle-mediated transportEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
bone mineralizationEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
negative regulation of cell growthEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
melanocyte differentiationEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
regulation of bone mineralizationEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
negative regulation of bone mineralizationEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
inorganic diphosphate transportEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
intracellular phosphate ion homeostasisEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
sequestering of triglycerideEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
negative regulation of protein autophosphorylationEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
cellular response to insulin stimulusEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
response to ATPEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
negative regulation of fat cell differentiationEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
negative regulation of glycogen biosynthetic processEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
ATP metabolic processEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
negative regulation of glucose importEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
3'-phosphoadenosine 5'-phosphosulfate metabolic processEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
phosphate ion homeostasisEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
nucleic acid metabolic processEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
negative regulation of hh target transcription factor activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (20)

Processvia Protein(s)Taxonomy
nucleic acid bindingEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
3',5'-cyclic-AMP phosphodiesterase activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
exonuclease activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
phosphodiesterase I activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
dinucleotide phosphatase activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
scavenger receptor activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
insulin receptor bindingEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
calcium ion bindingEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
protein bindingEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
ATP bindingEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
zinc ion bindingEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
phosphatase activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
polysaccharide bindingEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
GTP diphosphatase activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
UTP diphosphatase activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
protein homodimerization activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
nucleoside triphosphate diphosphatase activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
ATP diphosphatase activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
3'-phosphoadenosine 5'-phosphosulfate bindingEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
cyclic-GMP-AMP hydrolase activityEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
plasma membraneEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
extracellular spaceEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
lysosomal membraneEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
plasma membraneEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
cell surfaceEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
membraneEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
basolateral plasma membraneEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
cell surfaceEctonucleotide pyrophosphatase/phosphodiesterase family member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1346645Mouse P2X7 (P2X receptors)2009British journal of pharmacology, Aug, Volume: 157, Issue:7
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
AID1346612Human P2X7 (P2X receptors)2009British journal of pharmacology, Aug, Volume: 157, Issue:7
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
AID1346335Human P2Y11 receptor (P2Y receptors)1999British journal of pharmacology, Nov, Volume: 128, Issue:6
Pharmacological characterization of the human P2Y11 receptor.
AID1346648Rat P2X7 (P2X receptors)2009British journal of pharmacology, Aug, Volume: 157, Issue:7
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
AID1415777Competitive-inhibition of recombinant human N-terminal His-tagged soluble NPP1 (Val191 to Leu591 residues) expressed in mouse NSO cells using ATP as substrate after 30 mins by capillary electrophoresis method2017MedChemComm, May-01, Volume: 8, Issue:5
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors.
AID760104Agonist activity at P2X7 in Sprague-Dawley rat synaptosome assessed as [3H]D-aspartate efflux preincubated at 100 uM for 8 mins by liquid scintillation counting2013ACS medicinal chemistry letters, Aug-08, Volume: 4, Issue:8
Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release.
AID1415784Competitive-inhibition of recombinant human NPP1 expressed in HEK293 cell membranes using p-Nph-5'-TMP as substrate pretreated for 10 mins followed by substrate addition and measured after 60 mins by capillary electrophoresis method2017MedChemComm, May-01, Volume: 8, Issue:5
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors.
AID1415787Competitive-inhibition of Wistar rat NPP1 using p-Nph-5'-TMP as substrate measured after 5 mins by UPLC method2017MedChemComm, May-01, Volume: 8, Issue:5
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (415)

TimeframeStudies, This Drug (%)All Drugs %
pre-199016 (3.86)18.7374
1990's69 (16.63)18.2507
2000's168 (40.48)29.6817
2010's150 (36.14)24.3611
2020's12 (2.89)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.24%)5.53%
Reviews3 (0.71%)6.00%
Case Studies1 (0.24%)4.05%
Observational0 (0.00%)0.25%
Other415 (98.81%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
suramin[no description available]medium170naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
2'-deoxyadenosine triphosphate[no description available]medium102'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
Reactive blue 2[no description available]medium10anthraquinone
ar c67085mx[no description available]medium10
2-methylthio-atp[no description available]medium170
adp beta s[no description available]medium30
a-839977[no description available]medium30
a-438079[no description available]medium10
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid[no description available]medium210arenesulfonic acid;
azobenzenes;
methylpyridines;
monohydroxypyridine;
organic phosphate;
pyridinecarbaldehyde		purinergic receptor P2X antagonist
alpha,beta-methyleneadenosine 5'-triphosphate[no description available]medium180nucleoside triphosphate analogue
adenosine 5'-methylenediphosphate[no description available]medium10nucleoside diphosphate analogue
methylthio-adp[no description available]medium70
adenosine 5'-diphosphate 2',3'-dialdehyde[no description available]medium10
arl-67156[no description available]medium20
tyrosine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
adamantane[no description available]medium40adamantanes;
polycyclic alkane
az10606120[no description available]medium20
n-methylaspartate[no description available]medium50amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
caffeine[no description available]medium20purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
retinol[no description available]medium10retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite
crocin[no description available]medium10
trans-sodium crocetinate[no description available]medium10
Dihydrotanshinone I[no description available]medium10abietane diterpenoidanticoronaviral agent
phenanthrenes[no description available]medium10
yo-pro 1[no description available]medium230
thiourea[no description available]medium10one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
urea[no description available]medium10isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
benzoxazoles[no description available]medium2301,3-benzoxazoles;
mancude organic heterobicyclic parent
acetovanillone[no description available]medium10acetophenones;
aromatic ketone;
methyl ketone		antirheumatic drug;
EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite
c.i. 42510[no description available]medium171
coomassie brilliant blue[no description available]medium171
pectenotoxin 6[no description available]medium10polycyclic ether;
spiroketal		marine metabolite
bradykinin[no description available]medium40oligopeptidehuman blood serum metabolite;
vasodilator agent
zidovudine[no description available]medium10azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
4-aminopyridine[no description available]medium20aminopyridine;
aromatic amine		avicide;
orphan drug;
potassium channel blocker
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid[no description available]medium10non-proteinogenic alpha-amino acid
phenytoin[no description available]medium10imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
gabapentin[no description available]medium10gamma-amino acidanticonvulsant;
calcium channel blocker;
environmental contaminant;
xenobiotic
muscimol[no description available]medium10alkaloid;
isoxazoles;
primary amino compound		fungal metabolite;
GABA agonist;
oneirogen;
psychotropic drug
tetrodotoxin[no description available]medium30azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
valproic acid[no description available]medium20branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent
cystine[no description available]medium10
glutamic acid[no description available]medium170glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
alpha-synuclein[no description available]medium10
nigericin[no description available]medium10polycyclic etherantibacterial agent;
antimicrobial agent;
bacterial metabolite;
potassium ionophore
nnc 55-0396[no description available]medium10hydrochlorideangiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
potassium channel blocker;
T-type calcium channel blocker
2',3'-dialdehyde atp[no description available]medium230
2-amino-5-phosphonovalerate[no description available]medium30non-proteinogenic alpha-amino acidNMDA receptor antagonist
phorbol 12,13-dibutyrate[no description available]medium10butyrate ester;
phorbol ester;
tertiary alpha-hydroxy ketone
triethylammonium cation[no description available]medium10ammonium ion derivative
pyridoxal phosphate[no description available]medium200methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate		coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
Brilliant Blue[no description available]medium70organic molecular entity
niacinamide[no description available]medium20pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
jnj-47965567[no description available]medium20
pd 98059[no description available]medium40aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
bisindolylmaleimide i[no description available]medium20
adenosine diphosphate[no description available]medium190adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
uridine triphosphate[no description available]medium310pyrimidine ribonucleoside 5'-triphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
arginine vasopressin[no description available]medium10vasopressincardiovascular drug;
hematologic agent;
mitogen
ethidium[no description available]medium250phenanthridinesfluorochrome;
intercalator
adenosine 5'-o-(3-thiotriphosphate)[no description available]medium170nucleoside triphosphate analogue
adenosine monophosphate[no description available]medium30adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
hydrogen sulfide[no description available]medium10gas molecular entity;
hydracid;
mononuclear parent hydride;
sulfur hydride		Escherichia coli metabolite;
genotoxin;
metabolite;
signalling molecule;
toxin;
vasodilator agent
guanosine monophosphate[no description available]medium10guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite
adenosine[no description available]medium130adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
adenosine 5'-phosphorothioate[no description available]medium10
guanosine 5'-monophosphorothioate[no description available]medium10
alendronate[no description available]medium101,1-bis(phosphonic acid);
primary amino compound		bone density conservation agent;
EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor
apyrase[no description available]medium40
interleukin-8[no description available]medium30
acetylcysteine[no description available]medium10acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
taurine[no description available]medium10amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
bromodeoxyuridine[no description available]medium30pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
myelin basic protein[no description available]medium10
fura-2[no description available]medium80
1-(5-isoquinolinesulfonyl)-2-methylpiperazine[no description available]medium210isoquinolines;
N-sulfonylpiperazine		EC 2.7.11.13 (protein kinase C) inhibitor
kn 62[no description available]medium210piperazines
2,4-dinitrobenzenesulfonic acid[no description available]medium10arenesulfonic acid;
C-nitro compound
serine[no description available]medium50L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
temozolomide[no description available]medium10imidazotetrazine;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent;
prodrug
dacarbazine[no description available]medium10dacarbazine
kainic acid[no description available]medium10dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
dinoprostone[no description available]medium30prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
cay 10404[no description available]medium10sulfonic acid derivative
isoxazoles[no description available]medium10isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
morphine[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
phosphorylcholine[no description available]medium20phosphocholinesallergen;
epitope;
hapten;
human metabolite;
mouse metabolite
nicotine[no description available]medium303-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
choline[no description available]medium40cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
gamma-aminobutyric acid[no description available]medium30amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
benzofurans[no description available]medium10
decitabine[no description available]medium102'-deoxyribonucleoside
azacitidine[no description available]medium10N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
naringin[no description available]medium10(2S)-flavan-4-one;
4'-hydroxyflavanones;
dihydroxyflavanone;
disaccharide derivative;
neohesperidoside		anti-inflammatory agent;
antineoplastic agent;
metabolite
fluoxetine[no description available]medium10(trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound
paroxetine[no description available]medium10aromatic ether;
benzodioxoles;
organofluorine compound;
piperidines		antidepressant;
anxiolytic drug;
hepatotoxic agent;
P450 inhibitor;
serotonin uptake inhibitor
desipramine[no description available]medium10dibenzoazepine;
secondary amino compound		adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor
pilocarpine[no description available]medium40pilocarpineantiglaucoma drug
thiophenes[no description available]medium10mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
neuropeptide y[no description available]medium10
leptin[no description available]medium10
6-cyano-7-nitroquinoxaline-2,3-dione[no description available]medium20quinoxaline derivative
acetaldehyde[no description available]medium10aldehydecarcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent
flufenamic acid[no description available]medium10aromatic amino acid;
organofluorine compound		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
mefloquine[no description available]medium20
carbenoxolone sodium[no description available]medium50triterpenoid
azides[no description available]medium40pseudohalide anionmitochondrial respiratory-chain inhibitor
2-azidoadenosine 5'-triphosphate[no description available]medium10
arachidonic acid[no description available]medium50icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
tetradecanoylphorbol acetate[no description available]medium140acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
colforsin[no description available]medium40acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
alanine[no description available]medium30alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
dextrothyroxine[no description available]medium20
thiazolyl blue[no description available]medium10organic bromide saltcolorimetric reagent;
dye
1,2-bis(2-aminophenoxy)ethane n,n,n',n'-tetraacetic acid acetoxymethyl ester[no description available]medium10
staurosporine[no description available]medium50ammonium ion derivative
egtazic acid[no description available]medium60diether;
tertiary amino compound;
tetracarboxylic acid		chelator
thiazoles[no description available]medium401,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
imipramine[no description available]medium10dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
glycine[no description available]medium40alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
vanadates[no description available]medium20trivalent inorganic anion;
vanadium oxoanion		EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
az 11645373[no description available]medium30
gw791343[no description available]medium20
9,10-dimethyl-1,2-benzanthracene[no description available]medium10ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one[no description available]medium30chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector
2',3'-o-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate[no description available]medium70C-nitro compound;
spiroketal		antagonist
aspartic acid[no description available]medium30aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
gamma-glutamylmethylamide[no description available]medium10
hydrazine[no description available]medium10azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
1,1-diethyl-2-hydroxy-2-nitrosohydrazine[no description available]medium10organic anion
thapsigargicin[no description available]medium10
u 73122[no description available]medium50aromatic ether;
aza-steroid;
maleimides		EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor
sesquiterpenes[no description available]medium10
1,3-dipropyl-8-cyclopentylxanthine[no description available]medium20oxopurineadenosine A1 receptor antagonist;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
sb 203580[no description available]medium30imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent
emodin[no description available]medium10trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
pyrazolanthrone[no description available]medium10anthrapyrazole;
aromatic ketone;
cyclic ketone		antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector
rtki cpd[no description available]medium10
quinazolines[no description available]medium10azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
carbachol[no description available]medium50ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
mocetinostat[no description available]medium10aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
fura-2-am[no description available]medium20
propofol[no description available]medium10phenolsanticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative
sphingosine[no description available]medium20sphing-4-eninehuman metabolite;
mouse metabolite
sphingosine 1-phosphate[no description available]medium10sphingoid 1-phosphatemouse metabolite;
signalling molecule;
sphingosine-1-phosphate receptor agonist;
T-cell proliferation inhibitor;
vasodilator agent
phenylephrine[no description available]medium10phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
bmy 7378[no description available]medium10
sdz psc 833[no description available]medium10homodetic cyclic peptide
verapamil[no description available]medium20aromatic ether;
nitrile;
polyether;
tertiary amino compound
triphenyltetrazolium[no description available]medium10organic cation
erythrosine[no description available]medium20
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole[no description available]medium30ether;
imidazoles;
monomethoxybenzene		TRP channel blocker
dinitrofluorobenzene[no description available]medium10C-nitro compound;
organofluorine compound		agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent
2,4-dinitrofluorobenzene sulfonic acid[no description available]medium10
histidine[no description available]medium10amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
gadolinium chloride[no description available]medium10gadolinium coordination entityTRP channel blocker
gadolinium[no description available]medium10f-block element atom;
lanthanoid atom
quinacrine[no description available]medium10acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound		antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
cytidine triphosphate[no description available]medium30cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite
ethylmaleimide[no description available]medium40maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
o-ethyl o-4-nitrophenyl phosphoramidate[no description available]medium10
5'-adenylyl (beta,gamma-methylene)diphosphonate[no description available]medium40nucleoside triphosphate analogue
nitrophenols[no description available]medium10
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid[no description available]medium50
vasoactive intestinal peptide[no description available]medium30
sq-23377[no description available]medium30cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid		calcium ionophore;
metabolite
calcimycin[no description available]medium30benzoxazole
hexadimethrine bromide[no description available]medium10
thymidine monophosphate[no description available]medium10thymidine 5'-monophosphatefundamental metabolite
thymidine 5'-4-nitrophenyl phosphate[no description available]medium10aryl phosphate;
C-nitro compound;
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate
rimorphin[no description available]medium10
alpha-neoendorphin[no description available]medium10
dynorphins[no description available]medium10
cysteine[no description available]medium30cysteiniumfundamental metabolite
fenamic acid[no description available]medium10aminobenzoic acid;
secondary amino compound		membrane transport modulator
5-nitro-2-(3-phenylpropylamino)benzoic acid[no description available]medium10nitrobenzoic acid
glyburide[no description available]medium20monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
chlorine[no description available]medium50halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
lucifer yellow[no description available]medium20organic lithium saltfluorochrome
adenosine-5'-(n-ethylcarboxamide)[no description available]medium10adenosines;
monocarboxylic acid amide		adenosine A1 receptor agonist;
adenosine A2A receptor agonist;
antineoplastic agent;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
uridine diphosphate[no description available]medium20pyrimidine ribonucleoside 5'-diphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
go 6976[no description available]medium10indolocarbazole;
organic heterohexacyclic compound		EC 2.7.11.13 (protein kinase C) inhibitor
transforming growth factor beta[no description available]medium10
nf 279[no description available]medium10
u 0126[no description available]medium10aryl sulfide;
dinitrile;
enamine;
substituted aniline		antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
osteogenesis regulator;
vasoconstrictor agent
adenylyl imidodiphosphate[no description available]medium30adenosine 5'-phosphate
proline[no description available]medium10amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
leucine[no description available]medium10amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
maitotoxin[no description available]medium40
w 7[no description available]medium20
cytochalasin d[no description available]medium10
y 27632[no description available]medium10aromatic amide
chlorine[no description available]medium10diatomic chlorine;
gas molecular entity		bleaching agent
nifedipine[no description available]medium20C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
a-317491[no description available]medium10
paclitaxel[no description available]medium10taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
u 73343[no description available]medium10
verlukast[no description available]medium10
l 663536[no description available]medium10aryl sulfide;
indoles;
monocarboxylic acid;
monochlorobenzenes		antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
leukotriene antagonist
bicuculline[no description available]medium10benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
8-(3-chlorostyryl)caffeine[no description available]medium10monochlorobenzenes;
trimethylxanthine		adenosine A2A receptor antagonist;
EC 1.4.3.4 (monoamine oxidase) inhibitor
n(6)-methyl-2'-deoxyadenosine[no description available]medium10purine 2'-deoxyribonucleoside
minocycline[no description available]medium10
asparagine[no description available]medium20amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
threonine[no description available]medium10amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
glutamine[no description available]medium10amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
epibatidine[no description available]medium10
theophylline[no description available]medium10dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
thymidine[no description available]medium20pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
8-(4-sulfophenyl)theophylline[no description available]medium10
2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide[no description available]medium10
sb 202190[no description available]medium10imidazoles;
organofluorine compound;
phenols;
pyridines		apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
sb 242235[no description available]medium10
xanthenes[no description available]medium10xanthene
lysine[no description available]medium30aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
lysophosphatidylcholines[no description available]medium101-O-acyl-sn-glycero-3-phosphocholine
lithium chloride[no description available]medium10inorganic chloride;
lithium salt		antimanic drug;
geroprotector
cesium[no description available]medium10alkali metal atom
niflumic acid[no description available]medium10aromatic carboxylic acid;
pyridines
12-hydroxy-5,8,10,14-eicosatetraenoic acid[no description available]medium10
resorufin[no description available]medium10phenoxazine
amplex red[no description available]medium10
propidium[no description available]medium10phenanthridines;
quaternary ammonium ion		fluorochrome;
intercalator
fm1 43[no description available]medium10organic bromide salt;
pyridinium salt;
quaternary ammonium salt;
tertiary amine		fluorochrome
calcitriol[no description available]medium10D3 vitamins;
hydroxycalciol;
triol		antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical
thapsigargin[no description available]medium30butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
3'-o-anthraniloyl atp[no description available]medium10
3'-o-(n-methylanthraniloyl) atp[no description available]medium10
5-(n,n-hexamethylene)amiloride[no description available]medium20aromatic amine;
azepanes;
guanidines;
monocarboxylic acid amide;
organochlorine compound;
pyrazines		antineoplastic agent;
apoptosis inducer;
odorant receptor antagonist;
sodium channel blocker
amiloride[no description available]medium30aromatic amine;
guanidines;
organochlorine compound;
pyrazines		diuretic;
sodium channel blocker
guanosine triphosphate[no description available]medium60guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
fluorescein-5-isothiocyanate[no description available]medium10fluorescein isothiocyanate
ryanodine[no description available]medium10
bucladesine[no description available]medium203',5'-cyclic purine nucleotide
meglumine[no description available]medium10hexosamine;
secondary amino compound
inositol 1,4,5-trisphosphate[no description available]medium10myo-inositol trisphosphatemouse metabolite
thymidine 5'-triphosphate[no description available]medium10pyrimidine 2'-deoxyribonucleoside 5'-triphosphate;
thymidine phosphate		Escherichia coli metabolite;
mouse metabolite
guanosine diphosphate[no description available]medium20guanosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
calmidazolium[no description available]medium20imidazolium ionapoptosis inducer;
calmodulin antagonist
potassium chloride[no description available]medium20inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
atropine[no description available]medium20
diltiazem[no description available]medium105-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent
barium[no description available]medium30alkaline earth metal atom;
elemental barium
guanosine 5'-o-(2-thiodiphosphate)[no description available]medium10nucleoside diphosphate analogue
1-methyl-3-isobutylxanthine[no description available]medium103-isobutyl-1-methylxanthine
ro 31-9790[no description available]medium10
5'-(4-fluorosulfonylbenzoyl)adenosine[no description available]medium20
nickel[no description available]medium10metal allergen;
nickel group element atom		epitope;
micronutrient
manganese[no description available]medium20elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
oleic acid[no description available]medium10octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
alprostadil[no description available]medium10prostaglandins Eanticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent
creatine[no description available]medium10glycine derivative;
guanidines;
zwitterion		geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical
tromethamine[no description available]medium10primary amino compound;
triol		buffer
tricine[no description available]medium10tricine
phosphorus radioisotopes[no description available]medium20
3-(n-maleimidopropionyl)biocytin[no description available]medium10peptide
2-methylthioadenosine[no description available]medium10
adenosine-3',5'-cyclic phosphorothioate[no description available]medium10nucleoside 3',5'-cyclic phosphorothioate
sphingosine phosphorylcholine[no description available]medium10
sodium glutamate[no description available]medium10monosodium glutamateflavouring agent
kn 04[no description available]medium10
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
baclofen[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound		central nervous system depressant;
GABA agonist;
muscle relaxant
propranolol[no description available]medium10naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
tenidap[no description available]medium10
concanavalin a[no description available]medium10
guanosine 5'-o-(3-thiotriphosphate)[no description available]medium30nucleoside triphosphate analogue
digitonin[no description available]medium10
1-hexadecyl-2-acetyl-glycero-3-phosphocholine[no description available]medium102-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
rubidium[no description available]medium10alkali metal atom
3'-o-(4-benzoyl)benzoyladenosine diphosphate[no description available]medium20
8-azidoadenosine 5'-triphosphate[no description available]medium20
inositol[no description available]medium10cyclitol;
hexol
dicyclohexylcarbodiimide[no description available]medium10carbodiimideATP synthase inhibitor;
cross-linking reagent;
peptide coupling reagent
carbodiimides[no description available]medium10carbodiimide
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure0low10
Absence Seizures0low10
Absence Status0low40
Academic Disorder, Developmental0low10
Ache0low40
Acne0low10
Acne Vulgaris0low10
Acute Brain Injuries0low10
Acute Confusional Senile Dementia0low50
Acute Lung Injury0low10
Adamantiades-Behcet Disease0low10
ADPKD0low10
Adult Learning Disabilities0low10
Adult Learning Disorders0low10
Adult Polycystic Kidney Disease0low10
Adult Polycystic Kidney Disease Type 10low10
Adult Polycystic Kidney Disease Type 20low10
Affective Psychosis, Bipolar0low10
Age-Related Memory Disorders0low10
Aging0low30
Albuminuria0low20
Alcoholic Liver Diseases0low10
Allodynia0low60
Allodynia, Mechanical0low60
Allodynia, Tactile0low60
Allodynia, Thermal0low60
Alloxan Diabetes0low70
ALS - Amyotrophic Lateral Sclerosis0low20
Alzheimer Dementia0low50
Alzheimer Disease0low50
Alzheimer Disease, Early Onset0low50
Alzheimer Disease, Late Onset0low50
Alzheimer Sclerosis0low50
Alzheimer Syndrome0low50
Alzheimer Type Senile Dementia0low50
Alzheimer-Type Dementia (ATD)0low50
Alzheimer's Disease0low50
Alzheimer's Disease, Focal Onset0low50
Alzheimer's Diseases0low50
Amyotrophic Lateral Sclerosis0low20
Amyotrophic Lateral Sclerosis With Dementia0low20
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 10low20
Amyotrophic Lateral Sclerosis, Guam Form0low20
Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam0low20
Anaplastic Astrocytoma0low40
Angiogenesis, Pathologic0low10
Angiogenesis, Pathological0low10
Anhedonia0low10
Ankylosing Spondylarthritis0low10
Ankylosing Spondylitis0low10
Ankylosing Spondyloarthritis0low10
Anoxemia0low40
Anoxia0low40
Anoxia-Ischemia, Brain0low10
Anoxia-Ischemia, Cerebral0low10
Anoxic-Ischemic Encephalopathy0low10
Anterior Circulation Transient Ischemic Attack0low10
Apoplexy0low10
Arthritis, Degenerative0low10
Arthritis, Rheumatoid0low10
Arthroses0low10
Arthrosis0low10
Asthma0low10
Asthma, Bronchial0low10
Astrocytoma0low40
Astrocytoma, Grade I0low40
Astrocytoma, Grade II0low40
Astrocytoma, Grade III0low40
Astrocytoma, Grade IV0low10
Astrocytoma, Protoplasmic0low40
Astrocytoma, Subependymal Giant Cell0low40
Astrocytosis0low30
Astroglioma0low40
Astrogliosis0low30
Asymmetric Diabetic Proximal Motor Neuropathy0low10
Atonic Absence Seizure0low10
Atonic Absence Seizures0low10
Atonic Seizure0low10
Atonic Seizures0low10
Atrophy, Muscle0low10
Aura0low10
Autoimmune Diabetes0low10
Autosomal Dominant Polycystic Kidney0low10
Awakening Epilepsy0low10
B-Cell Chronic Lymphocytic Leukemia0low50
B-Cell Leukemia, Chronic0low50
B-Cell Malignancy, Low-Grade0low50
B-Lymphocytic Leukemia, Chronic0low50
Bechterew Disease0low10
Bechterew's Disease0low10
Becker Muscular Dystrophy0low10
Becker's Muscular Dystrophy0low10
Behcet Disease0low10
Behcet Syndrome0low10
Behcet Triple Symptom Complex0low10
Behcet's Disease0low10
Behcet's Syndrome0low10
Behu00E7et Disease0low10
Benign Neoplasms, Brain0low20
Benign Psychomotor Epilepsy, Childhood0low10
Besnier-Boeck Disease0low10
Besnier-Boeck-Schaumann Syndrome0low10
Bipolar Disorder0low10
Bipolar Mood Disorder0low10
Blood Pressure, High0low10
Body Weight0low10
Boeck Disease0low10
Boeck's Disease0low10
Boeck's Sarcoid0low10
Bone Cancer0low10
Bone Neoplasms0low10
Brain Anoxia-Ischemia0low10
Brain Cancer0low20
Brain Edema0medium21
Brain Hemorrhage, Cerebral0low10
Brain Hypoxia-Ischemia0low10
Brain Inflammation0medium31
Brain Injuries0low10
Brain Injuries, Acute0low10
Brain Injuries, Focal0low10
Brain Ischemia0low10
Brain Ischemia-Anoxia0low10
Brain Ischemia-Hypoxia0low10
Brain Lacerations0low10
Brain Metastases0low20
Brain Neoplasm, Primary0low20
Brain Neoplasms0low20
Brain Neoplasms, Benign0low20
Brain Neoplasms, Malignant0low20
Brain Neoplasms, Malignant, Primary0low20
Brain Neoplasms, Primary Malignant0low20
Brain Stem Ischemia, Transient0low10
Brain Stem Transient Ischemic Attack0low10
Brain Swelling0medium21
Brain TIA0low10
Brain Tumor, Primary0low20
Brain Tumor, Recurrent0low20
Brain Tumors0low20
Brainstem Ischemia, Transient0low10
Brainstem Transient Ischemic Attack0low10
Breast Cancer0low10
Breast Carcinoma0low10
Breast Neoplasms0low10
Breast Tumors0low10
Bronchial Asthma0low10
Cancer of Bone0low10
Cancer of Brain0low20
Cancer of Breast0low10
Cancer of Cervix0low30
Cancer of Liver0low10
Cancer of Ovary0low20
Cancer of Skin0low10
Cancer of the Bone0low10
Cancer of the Brain0low20
Cancer of the Breast0low10
Cancer of the Cervix0low30
Cancer of the Liver0low10
Cancer of the Ovary0low20
Cancer of the Skin0low10
Cancer of the Uterine Cervix0low30
Cancer, Hepatocellular0low10
Carcinoma, Epidermoid0low10
Carcinoma, Hepatocellular0low10
Carcinoma, Planocellular0low10
Carcinoma, Squamous0low10
Carcinoma, Squamous Cell0low10
Carcinoma, Thymic0low10
Cardiometabolic Syndrome0low10
Cardiomyopathy, Dilated, 3B0low10
Cardiomyopathy, Dilated, X-Linked0low10
Cardiovascular Stroke0low10
Carotid Circulation Transient Ischemic Attack0low10
Cell Transformation, Neoplastic0low10
Cerebral Anoxia-Ischemia0low10
Cerebral Astrocytoma0low40
Cerebral Edema0medium21
Cerebral Edema, Cytotoxic0medium21
Cerebral Edema, Vasogenic0medium21
Cerebral Hemorrhage0low10
Cerebral Hypoxia-Ischemia0low10
Cerebral Infarction, Middle Cerebral Artery0low40
Cerebral Ischemia0low10
Cerebral Ischemia-Anoxia0low10
Cerebral Ischemia-Hypoxia0low10
Cerebral Ischemia, Transient0low10
Cerebral Parenchymal Hemorrhage0low10
Cerebral Stroke0low10
Cerebrovascular Accident0low10
Cerebrovascular Accident, Acute0low10
Cerebrovascular Apoplexy0low10
Cerebrovascular Stroke0low10
Cervical Cancer0low30
Cervical Neoplasms0low30
Cervix Cancer0low30
Cervix Neoplasms0low30
Charcot Disease0low20
Childhood Benign Psychomotor Epilepsy0low10
Childhood Cerebral Astrocytoma0low40
Childhood Muscular Dystrophy, Pseudohypertrophic0low10
Childhood Pseudohypertrophic Muscular Dystrophy0low10
Chlamydia Infections0low10
Choroid Neoplasms0low10
Choroidal Neoplasms0low10
Chronic Disease0low20
Chronic Illness0low20
Chronic Kidney Diseases0low10
Chronic Kidney Insufficiency0low10
Chronic Lymphocytic Leukemia0low50
Chronic Pain0low10
Chronic Renal Diseases0low10
Chronic Renal Insufficiency0low10
Chronically Ill0low20
Cirrhosis0low10
Clonic Seizure0low10
Clonic Seizures0low10
Colitis0low20
Complex Partial Seizure0low10
Complex Partial Seizures0low10
Complex Partial Status Epilepticus0low40
Constriction, Pathologic0low10
Constriction, Pathological0low10
Convulsion0low10
Convulsion, Non-Epileptic0low10
Convulsions0low10
Convulsive Seizure0low10
Convulsive Seizures0low10
Cranial Nerve II Injuries0low10
Crescendo Transient Ischemic Attacks0low10
CVA (Cerebrovascular Accident)0low10
Cytotoxic Brain Edema0medium21
Cytotoxic Cerebral Edema0medium21
Deficiency, Oxygen0low40
Degenerative Diseases, Central Nervous System0low10
Degenerative Diseases, Nervous System0low10
Degenerative Diseases, Neurologic0low10
Degenerative Diseases, Spinal Cord0low10
Degenerative Neurologic Diseases0low10
Degenerative Neurologic Disorders0low10
Dementia With Amyotrophic Lateral Sclerosis0low20
Dementia, Alzheimer Type0low50
Dementia, Presenile0low50
Dementia, Primary Senile Degenerative0low50
Dementia, Senile0low50
Depression0low20
Depression, Bipolar0low10
Depression, Endogenous0low10
Depression, Neurotic0low10
Depression, Unipolar0low10
Depressive Disorder0low10
Depressive Syndrome0low10
Dermatitis Seborrheica0low10
Dermatitis, Seborrheic0low10
Developmental Academic Disability0low10
Developmental Academic Disorder0low10
Developmental Disabilities of Scholastic Skills0low10
Developmental Disorders of Scholastic Skills0low10
Diabetes Mellitus, Adult-Onset0low20
Diabetes Mellitus, Brittle0low10
Diabetes Mellitus, Experimental0low70
Diabetes Mellitus, Insulin-Dependent0low10
Diabetes Mellitus, Insulin-Dependent, 10low10
Diabetes Mellitus, Juvenile-Onset0low10
Diabetes Mellitus, Ketosis-Prone0low10
Diabetes Mellitus, Ketosis-Resistant0low20
Diabetes Mellitus, Maturity-Onset0low20
Diabetes Mellitus, Non Insulin Dependent0low20
Diabetes Mellitus, Non-Insulin-Dependent0low20
Diabetes Mellitus, Noninsulin Dependent0low20
Diabetes Mellitus, Noninsulin-Dependent0low20
Diabetes Mellitus, Slow-Onset0low20
Diabetes Mellitus, Stable0low20
Diabetes Mellitus, Sudden-Onset0low10
Diabetes Mellitus, Type 10low10
Diabetes Mellitus, Type 20low20
Diabetes Mellitus, Type I0low10
Diabetes Mellitus, Type II0low20
Diabetes, Autoimmune0low10
Diabetic Amyotrophy0low10
Diabetic Angiopathies0low10
Diabetic Asymmetric Polyneuropathy0low10
Diabetic Autonomic Neuropathy0low10
Diabetic Glomerulosclerosis0low20
Diabetic Kidney Disease0low20
Diabetic Mononeuropathy0low10
Diabetic Mononeuropathy Simplex0low10
Diabetic Nephropathies0low20
Diabetic Nephropathy0low20
Diabetic Neuralgia0low10
Diabetic Neuropathies0low10
Diabetic Neuropathy, Painful0low10
Diabetic Polyneuropathy0low10
Diabetic Retinopathy0low20
Diabetic Vascular Complications0low10
Diabetic Vascular Diseases0low10
Diffuse Well-Differentiated Lymphocytic Lymphoma0low50
Disease Exacerbation0low20
Disease Models, Animal0medium261
Disease Progression0low20
Disrupted In B-Cell Malignancy0low50
Drug Withdrawal Symptoms0low10
Duchenne and Becker Muscular Dystrophy0low10
Duchenne Muscular Dystrophy0low10
Duchenne-Becker Muscular Dystrophy0low10
Duchenne-Type Progressive Muscular Dystrophy0low10
Dysmetabolic Syndrome X0low10
Early Onset Alzheimer Disease0low50
Embolic Infarction, Middle Cerebral Artery0low40
Embolus, Middle Cerebral Artery0low40
Encephalitis0medium31
Encephalitis, Rasmussen0medium31
Encephalopathy, Anoxic-Ischemic0low10
Encephalopathy, Hypoxic-Ischemic0low10
Encephalopathy, Ischemic0low10
Epilepsy0low10
Epilepsy, Benign Psychomotor, Childhood0low10
Epilepsy, Cryptogenic0low10
Epilepsy, Lateral Temporal0low10
Epilepsy, Temporal Lobe0low10
Epilepsy, Uncinate0low10
Epileptic Seizure0low10
Epileptic Seizures0low10
Experimental Diabetes Mellitus0low70
Experimental Leukemia0low10
Experimental Leukemias0low10
Extravascular Hemolysis0low10
Familial Alzheimer Disease (FAD)0low50
Fibrillary Astrocytoma0low40
Fibrosis0low10
Focal Brain Injuries0low10
Focal Onset Alzheimer's Disease0low50
Gehrig's Disease0low20
Gemistocytic Astrocytoma0low40
Generalized Absence Seizure0low10
Generalized Absence Seizures0low10
Generalized Convulsive Status Epilepticus0low40
Generalized Tonic-Clonic Seizures0low10
Germinoblastoma0low10
Giant Cell Glioblastoma0low10
Glaucoma, Suspect0low10
Glial Cell Tumors0low40
Glial Scar0low30
Glioblastoma0low10
Glioblastoma Multiforme0low10
Glioma0low40
Glioma, Astrocytic0low40
Gliosis0low30
Glomerulosclerosis, Diabetic0low20
Grand Mal Status Epilepticus0low40
Guam Disease0low20
Guam Form of Amyotrophic Lateral Sclerosis0low20
Haemolysis0low10
Heart Attack0low10
Hemolysis0low10
Hemorrhage, Cerebral0low10
Hemorrhage, Cerebrum0low10
Hemorrhage, Subarachnoid0medium21
Hepatic Cancer0low10
Hepatic Neoplasms0low10
Hepatocellular Cancer0low10
Hepatocellular Carcinoma0low10
Hepatoma0low10
Hospital-Acquired Condition0low10
Human Mammary Carcinoma0low10
Hyperalgesia0low60
Hyperalgesia, Mechanical0low60
Hyperalgesia, Primary0low60
Hyperalgesia, Secondary0low60
Hyperalgesia, Tactile0low60
Hyperalgesia, Thermal0low60
Hyperalgesic Sensations0low60
Hyperalgia0low60
Hyperalgia, Mechanical0low60
Hyperalgia, Primary0low60
Hyperalgia, Secondary0low60
Hyperglycemia0low10
Hyperglycemia, Postprandial0low10
Hypertension0low10
Hypertension, Ocular0low10
Hypertrophy0low10
Hypoxemia0low40
Hypoxia0low40
Hypoxia-Ischemia, Brain0low10
Hypoxia-Ischemia, Cerebral0low10
Hypoxic-Ischemic Encephalopathy0low10
Iatrogenic Disease0low10
IDDM0low10
Infarction, Middle Cerebral Artery0low40
Infection, Toxoplasma gondii0low10
Infections, Chlamydia0low10
Inflammation0low120
Inflammation, Brain0medium31
Injuries0low10
Injuries and Wounds0low10
Injuries, Acute Brain0low10
Injuries, Brain0low10
Injuries, Spinal Cord0low10
Injuries, Wounds0low10
Injury, Myocardial Reperfusion0low10
Innate Inflammatory Response0low120
Insulin Resistance Syndrome X0low10
Insulin-Dependent Diabetes Mellitus 10low10
Intracapillary Glomerulosclerosis0low20
Intracerebral Hemorrhage0low10
Intracranial Astrocytoma0low40
Intracranial Edema0medium21
Intracranial Neoplasms0low20
Intraocular Pressure0low20
Intravascular Hemolysis0low10
Ischemia0low20
Ischemia-Anoxia, Brain0low10
Ischemia-Anoxia, Cerebral0low10
Ischemia-Hypoxia, Brain0low10
Ischemia-Hypoxia, Cerebral0low10
Ischemia, Cerebral0low10
Ischemic Attack, Transient0low10
Ischemic Encephalopathy0low10
Ischemic-Hypoxic Encephalopathy0low10
Jacksonian Seizure0low10
Juvenile Pilocytic Astrocytoma0low40
Juvenile-Onset Diabetes0low10
Kidney Diseases0low10
Kidney Insufficiency, Chronic0low10
Kidney, Polycystic, Autosomal Dominant0low10
Kimmelstiel-Wilson Disease0low20
Kimmelstiel-Wilson Syndrome0low20
Late Onset Alzheimer Disease0low50
Learning Disabilities0low10
Learning Disorders0low10
Learning Disorders, Adult0low10
Learning Disturbance0low10
Left Middle Cerebral Artery Infarction0low40
Lesion of Sciatic Nerve0low10
Leucocythaemia0low10
Leucocythemia0low10
Leukemia0low10
Leukemia Model, Animal0low10
Leukemia, Acute Monocytic0low10
Leukemia, B Cell, Chronic0low50
Leukemia, B-Cell, Chronic0low50
Leukemia, Chronic Lymphatic0low50
Leukemia, Chronic Lymphocytic0low50
Leukemia, Chronic Lymphocytic, B-Cell0low50
Leukemia, Experimental0low10
Leukemia, Lymphoblastic, Chronic0low50
Leukemia, Lymphocytic, Chronic0low50
Leukemia, Lymphocytic, Chronic, B Cell0low50
Leukemia, Lymphocytic, Chronic, B-Cell0low50
Leukemia, Monoblastic, Acute0low10
Leukemia, Monocytic, Acute0low10
Leukemia, Myeloid, Acute, M50low10
Leukemia, Myeloid, Schilling Type0low10
Leukemia, Myeloid, Schilling-Type0low10
Leukemias, Experimental0low10
Liver Cancer0low10
Liver Cancer, Adult0low10
Liver Cell Carcinoma0low10
Liver Cell Carcinoma, Adult0low10
Liver Diseases, Alcoholic0low10
Liver Neoplasms0low10
Lou Gehrig Disease0low20
Lou Gehrig's Disease0low20
Lou-Gehrigs Disease0low20
Lung Injury, Acute0low10
Lymphoblastic Leukemia, Chronic0low50
Lymphocytic Leukemia, Chronic0low50
Lymphocytic Leukemia, Chronic, B Cell0low50
Lymphocytic Leukemia, Chronic, B-Cell0low50
Lymphocytic Lymphoma0low50
Lymphocytic Lymphoma, Diffuse, Well Differentiated0low50
Lymphocytic Lymphoma, Diffuse, Well-Differentiated0low50
Lymphocytic Lymphoma, Well Differentiated0low50
Lymphocytic Lymphoma, Well-Differentiated0low50
Lymphoma0low10
Lymphoma, Lymphocytic0low50
Lymphoma, Lymphocytic, Diffuse, Well Differentiated0low50
Lymphoma, Lymphocytic, Diffuse, Well-Differentiated0low50
Lymphoma, Lymphocytic, Well Differentiated0low50
Lymphoma, Lymphocytic, Well-Differentiated0low50
Lymphoma, Lymphoplasmacytoid, CLL0low50
Lymphoma, Malignant0low10
Lymphoma, Small Lymphocytic0low50
Lymphoma, Small Lymphocytic, Plasmacytoid0low50
Lymphoma, Small-Cell0low50
Lymphoplasmacytoid Lymphoma, CLL0low50
Malignant Glioma0low40
Malignant Melanoma0low10
Malignant Neoplasm of Breast0low10
Malignant Neoplasms, Brain0low20
Malignant Primary Brain Neoplasms0low20
Malignant Primary Brain Tumors0low20
Malignant Tumor of Breast0low10
Mammary Cancer0low10
Mammary Carcinoma, Human0low10
Mammary Neoplasm, Human0low10
Mammary Neoplasms, Human0low10
Manic Depression0low10
Manic Disorder0low10
Manic-Depressive Psychosis0low10
Marie-Struempell Disease0low10
Maturity-Onset Diabetes0low20
Maturity-Onset Diabetes Mellitus0low20
MCA Infarct0low40
MCA Infarction0low40
Mechanical Allodynia0low60
Mechanical Hyperalgesia0low60
Melancholia0low10
Melanoma0low10
Memory Deficits0low10
Memory Disorder, Semantic0low10
Memory Disorder, Spatial0low10
Memory Disorders0low10
Memory Disorders, Age-Related0low10
Memory Loss0low10
Menopause0low10
Metabolic Cardiovascular Syndrome0low10
Metabolic Syndrome0low10
Metabolic Syndrome X0low10
Metabolic X Syndrome0low10
Microangiopathy, Diabetic0low10
Middle Cerebral Artery Circulation Infarction0low40
Middle Cerebral Artery Embolic Infarction0low40
Middle Cerebral Artery Embolus0low40
Middle Cerebral Artery Infarction0low40
Middle Cerebral Artery Occlusion0low40
Middle Cerebral Artery Stroke0low40
Middle Cerebral Artery Syndrome0low40
Middle Cerebral Artery Thrombosis0low40
Middle Cerebral Artery Thrombotic Infarction0low40
Mixed Glioma0low40
MODY0low20
Monoblastic Leukemia, Acute0low10
Monocytic Leukemia, Acute0low10
Mononeuropathy, Diabetic0low10
Motor Neuron Disease, Amyotrophic Lateral Sclerosis0low20
MS (Multiple Sclerosis)0low20
Multiple Sclerosis0low20
Multiple Sclerosis, Acute Fulminating0low20
Muscle Contraction0low10
Muscle Relaxation0low20
Muscular Atrophy0low10
Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type0low10
Muscular Dystrophy, Becker0low10
Muscular Dystrophy, Becker Type0low10
Muscular Dystrophy, Childhood, Pseudohypertrophic0low10
Muscular Dystrophy, Duchenne0low10
Muscular Dystrophy, Duchenne and Becker Types0low10
Muscular Dystrophy, Duchenne Type0low10
Muscular Dystrophy, Pseudohypertrophic0low10
Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type0low10
Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type0low10
Muscular Dystrophy, Pseudohypertrophic, Childhood0low10
Myeloid Leukemia, Acute, M50low10
Myeloid Leukemia, Schilling-Type0low10
Myelopathy, Traumatic0low10
Myocardial Infarct0low10
Myocardial Infarction0low10
Myocardial Ischemic Reperfusion Injury0low10
Myocardial Reperfusion Injury0low10
Myoclonic Seizure0low10
Myoclonic Seizures0low10
Nasal Catarrh0low10
Nasal Polyps0low10
Necrosis0low10
Neoplasms, Bone0low10
Neoplasms, Brain0low20
Neoplasms, Brain, Benign0low20
Neoplasms, Brain, Malignant0low20
Neoplasms, Brain, Primary0low20
Neoplasms, Breast0low10
Neoplasms, Cervical0low30
Neoplasms, Cervix0low30
Neoplasms, Hepatic0low10
Neoplasms, Intracranial0low20
Neoplasms, Liver0low10
Neoplasms, Ovarian0low20
Neoplasms, Skin0low10
Neoplastic Cell Transformation0low10
Neoplastic Transformation, Cell0low10
Neovascularization, Pathologic0low10
Neovascularization, Pathological0low10
Nerve Degeneration0low10
Nerve Pain0low30
Nervous System Degenerative Diseases0low10
Nervous System Diseases0low10
Nervous System Disorders0low10
Neuralgia0low30
Neuralgia-Neuritis, Sciatic Nerve0low10
Neuralgia, Atypical0low30
Neuralgia, Diabetic0low10
Neuralgia, Iliohypogastric Nerve0low30
Neuralgia, Ilioinguinal0low30
Neuralgia, Perineal0low30
Neuralgia, Sciatic0low10
Neuralgia, Stump0low30
Neuralgia, Supraorbital0low30
Neuralgia, Vidian0low30
Neuroblastoma0low40
Neurodegenerative Diseases0low10
Neurodegenerative Disorders0low10
Neurodynia0low30
Neurogenic Muscular Atrophy0low10
Neurologic Degenerative Conditions0low10
Neurologic Degenerative Diseases0low10
Neurologic Diseases, Degenerative0low10
Neurologic Disorders0low10
Neurological Disorders0low10
Neuron Degeneration0low10
Neuropathic Pain0low30
Neurosis, Depressive0low10
Neurotrophic Muscular Atrophy0low10
NIDDM0low20
Nodular Glomerulosclerosis0low20
Non-Convulsive Status Epilepticus0low40
Non-Epileptic Seizure0low10
Non-Epileptic Seizures0low10
Nonepileptic Seizure0low10
Nonepileptic Seizures0low10
Noninsulin-Dependent Diabetes Mellitus0low20
Occlusion, Middle Cerebral Artery0low40
Ocular Hypertension0low10
Old Silk Route Disease0low10
Oligoastrocytoma, Mixed0low40
Optic Nerve Avulsion0low10
Optic Nerve Contusion0low10
Optic Nerve Injuries0low10
Optic Nerve Transection0low10
Optic Nerve Trauma0low10
Optic Neuropathy, Traumatic0low10
Osteoarthritis0low10
Osteoarthrosis0low10
Osteoarthrosis Deformans0low10
Ovarian Cancer0low20
Ovarian Neoplasms0low20
Ovary Cancer0low20
Ovary Neoplasms0low20
Oxygen Deficiency0low40
Pain0low40
Pain, Burning0low40
Pain, Chronic0low10
Pain, Crushing0low40
Pain, Migratory0low40
Pain, Radiating0low40
Pain, Splitting0low40
Papilloma0low10
Papilloma, Squamous Cell0low10
Papillomatosis0low10
Paroxysmal Nerve Pain0low30
Partial Seizure0low10
Partial Seizures0low10
Pathologic Angiogenesis0low10
Pathologic Constriction0low10
Pathologic Neovascularization0low10
Pericementitis0low10
Perinatal Subarachnoid Hemorrhage0medium21
Periodontitis0low10
Petit Mal Convulsion0low10
Petit Mal Status0low40
Physical Anhedonia0low10
Pilocytic Astrocytoma0low40
Polycystic Kidney Disease 20low10
Polycystic Kidney Disease, Adult0low10
Polycystic Kidney Disease, Adult Type 20low10
Polycystic Kidney Disease, Adult, Type II0low10
Polycystic Kidney Disease, Autosomal Dominant0low10
Polycystic Kidney Disease, Type 20low10
Polycystic Kidney, Autosomal Dominant0low10
Polycystic Kidney, Type 1 Autosomal Dominant Disease0low10
Polycystic Kidney, Type 2 Autosomal Dominant Disease0low10
Post-Traumatic Myelopathy0low10
Posterior Circulation Transient Ischemic Attack0low10
Postprandial Hyperglycemia0low10
Pregnancy0low60
Presenile Alzheimer Dementia0low50
Primary Brain Neoplasms0low20
Primary Malignant Brain Neoplasms0low20
Primary Malignant Brain Tumors0low20
Primary Senile Degenerative Dementia0low50
Progressive Muscular Dystrophy, Duchenne Type0low10
Proliferative Vitreoretinopathy0low20
Pseudohypertrophic Childhood Muscular Dystrophy0low10
Pseudohypertrophic Muscular Dystrophy, Childhood0low10
Psychoses, Manic-Depressive0low10
Psychosis, Manic-Depressive0low10
Rasmussen Encephalitis0medium31
Rasmussen Syndrome0medium31
Rasmussen's Syndrome0medium31
Reaven Syndrome X0low10
Renal Insufficiency, Chronic0low10
Reperfusion Injury, Myocardial0low10
Research-Related Injuries0low10
Retention Disorders, Cognitive0low10
Reticulolymphosarcoma0low10
Retinal Degeneration0low30
Rheumatoid Arthritis0low10
Rheumatoid Spondylitis0low10
Rhinitis0low10
Rida0low10
Right Middle Cerebral Artery Infarction0low40
SAH (Subarachnoid Hemorrhage)0medium21
Sarcoidosis0low10
Sarcoma, Germinoblastic0low10
Schaumann Disease0low10
Schaumann Syndrome0low10
Schaumann's Syndrome0low10
Schistosoma mansoni Infection0low10
Schistosomiasis mansoni0low10
Schistosomiasis, Intestinal0low10
Scholastic Skills Development Disorders0low10
Sciatic Nerve Diseases0low10
Sciatic Nerve Palsy0low10
Sciatic Neuralgia0low10
Sciatic Neuritis0low10
Sciatic Neuropathy0low10
Sciatica0low10
Sciatica, Bilateral0low10
Sclerosis, Disseminated0low20
Scrapie0low10
Seborrhea0low10
Seborrheic Dermatitis0low10
Second Cranial Nerve Injuries0low10
Second Cranial Nerve Trauma0low10
Seizure0low10
Seizure Disorder0low10
Seizures0low10
Seizures, Auditory0low10
Seizures, Clonic0low10
Seizures, Convulsive0low10
Seizures, Epileptic0low10
Seizures, Focal0low10
Seizures, Generalized0low10
Seizures, Gustatory0low10
Seizures, Motor0low10
Seizures, Olfactory0low10
Seizures, Sensory0low10
Seizures, Somatosensory0low10
Seizures, Tonic0low10
Seizures, Tonic-Clonic0low10
Seizures, Vertiginous0low10
Seizures, Vestibular0low10
Seizures, Visual0low10
Semantic Memory Disorder0low10
Senile Dementia, Acute Confusional0low50
Senile Dementia, Alzheimer Type0low50
Simple Partial Status Epilepticus0low40
Single Seizure0low10
Sinus Infections0low10
Sinusitis0low10
Skin Cancer0low10
Skin Neoplasms0low10
Small-Cell Lymphoma0low50
Social Anhedonia0low10
Spatial Memory Disorder0low10
Spinal Cord Contusion0low10
Spinal Cord Injuries0low10
Spinal Cord Laceration0low10
Spinal Cord Transection0low10
Spinal Cord Trauma0low10
Spondylarthritis Ankylopoietica0low10
Spondylitis Ankylopoietica0low10
Spondylitis, Ankylosing0low10
Spondyloarthritis Ankylopoietica0low10
Squamous Cell Carcinoma0low10
Status Epilepticus0low40
Status Epilepticus, Complex Partial0low40
Status Epilepticus, Electrographic0low40
Status Epilepticus, Generalized0low40
Status Epilepticus, Generalized Convulsive0low40
Status Epilepticus, Grand Mal0low40
Status Epilepticus, Non-Convulsive0low40
Status Epilepticus, Simple Partial0low40
Status Epilepticus, Subclinical0low40
Stenosis0low10
Streptozocin Diabetes0low70
Streptozotocin Diabetes0low70
Stricture0low10
Stroke0low10
Stroke, Acute0low10
Stroke, Middle Cerebral Artery0low40
Subarachnoid Hemorrhage0medium21
Subarachnoid Hemorrhage, Aneurysmal0medium21
Subarachnoid Hemorrhage, Intracranial0medium21
Subarachnoid Hemorrhage, Spontaneous0medium21
Subependymal Giant Cell Astrocytoma0low40
Substance Withdrawal Syndrome0low10
Suffering, Physical0low40
Symmetric Diabetic Proximal Motor Neuropathy0low10
Syndrome X, Insulin Resistance0low10
Syndrome X, Metabolic0low10
Tactile Allodynia0low60
Thermal Allodynia0low60
Thrombosis, Middle Cerebral Artery0low40
Thrombotic Infarction, Middle Cerebral Artery0low40
Thymoma0low10
TIA (Transient Ischemic Attack)0low10
Tonic Clonic Seizure0low10
Tonic Seizure0low10
Tonic Seizures0low10
Tonic-Clonic Seizure0low10
Tonic-Clonic Seizures0low10
Toxoplasma gondii Infection0low10
Toxoplasmosis0low10
Transformation, Neoplastic Cell0low10
Transient Ischemic Attack0low10
Transient Ischemic Attack, Anterior Circulation0low10
Transient Ischemic Attack, Brain Stem0low10
Transient Ischemic Attack, Brainstem0low10
Transient Ischemic Attack, Carotid Circulation0low10
Transient Ischemic Attack, Posterior Circulation0low10
Transient Ischemic Attack, Vertebrobasilar Circulation0low10
Transient Ischemic Attacks, Crescendo0low10
Trauma0low10
Trauma, Second Cranial Nerve0low10
Triple Symptom Complex0low10
Triple-Symptom Complex0low10
Tumorigenic Transformation0low10
Tumors, Breast0low10
Type 1 Diabetes0low10
Type 1 Diabetes Mellitus0low10
Type 2 Diabetes0low20
Type 2 Diabetes Mellitus0low20
Unipolar Depression0low10
Uterine Cervical Cancer0low30
Uterine Cervical Neoplasms0low30
Vascular Accident, Brain0low10
Vasogenic Brain Edema0medium21
Vasogenic Cerebral Edema0medium21
Vertebrobasilar Circulation Transient Ischemic Attack0low10
Visceral Pain0low10
Vitreoretinopathy Neovascular Inflammatory0low20
Vitreoretinopathy, Proliferative0low20
Wallerian Degeneration0low10
Widespread Chronic Pain0low10
Withdrawal Symptoms0low10
Wounds0low10
Wounds and Injuries0low10
Wounds and Injury0low10
Wounds, Injury0low10

Research Highlights

Safety/Toxicity (3)

ArticleYear
Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by taurine.
Pharmacological reports : PR, Volume: 66, Issue: 4		2014
Ca2+ store depletion and endoplasmic reticulum stress are involved in P2X7 receptor-mediated neurotoxicity in differentiated NG108-15 cells.
Journal of cellular biochemistry, Volume: 113, Issue: 4		2012
Increased resistance of glioma cell lines to extracellular ATP cytotoxicity.
Journal of neuro-oncology, Volume: 71, Issue: 2		2005
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (2)

ArticleYear
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
Journal of medicinal chemistry, 04-22, Volume: 64, Issue: 8		2021
Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors.
PloS one, Volume: 8, Issue: 6		2013
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (4)

ArticleYear
Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis.
Oncogene, Apr-02, Volume: 34, Issue: 14		2015
Modeling P2Y receptor-Ca2+ response coupling in taste cells.
Biochimica et biophysica acta, Volume: 1768, Issue: 7		2007
Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor.
Blood, Jun-15, Volume: 107, Issue: 12		2006
Non-genomic inhibition of human P2X7 purinoceptor by 17beta-oestradiol.
The Journal of physiology, May-01, Volume: 508 ( Pt 3)		1998
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]